Ras farnesylation inhibitor FTI-277 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis (Q34152634)

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English	Ras farnesylation inhibitor FTI-277 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5927130

Ras farnesylation inhibitor FTI-277 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis (English)

1 reference

Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5927130

cancer metastasis

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Setsuo Hirohashi

4

object named as

Setsuo Hirohashi

1 reference

Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5927130

Michiie Sakamoto

3

object named as

Michiie Sakamoto

1 reference

Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5927130

author name string

Jeong-Seok Nam

1

1 reference

Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5927130

Yoshinori Ino

2

1 reference

Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5927130

publication date

1 September 2002

1 reference

Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5927130

number of pages

9

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based on heuristic

inferred from page(s)

Japanese Journal of Cancer Research

1 reference

Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5927130

93

1 reference

Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5927130

9

1 reference

Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5927130

1020-1028

1 reference

Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5927130

Down-regulation of E-cadherin gene expression by collagen type I and type III in pancreatic cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

An inducible melanoma model implicates a role for RAS in tumor maintenance and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Novel Ras antagonist blocks human melanoma growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Ras-induced transformation and signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Regulation of E-cadherin gene expression during tumor progression: the role of a new Ets-binding site and the E-pal element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Inactivation of the E-cadherin-mediated cell adhesion system in human cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

A causal role for E-cadherin in the transition from adenoma to carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Rho-stimulated Contractility Contributes to the Fibroblastic Phenotype of Ras-transformed Epithelial Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Dominant negative inhibition of the association between beta-catenin and c-erbB-2 by N-terminally deleted beta-catenin suppresses the invasion and metastasis of cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Thymosin beta-4 expression is correlated with metastatic capacity of colorectal carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Cloning of the human alpha-catenin cDNA and its aberrant mRNA in a human cancer cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Cadherins in cancer: implications for invasion and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Multiple Ras functions can contribute to mammalian cell transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

c-erbB-2 gene product directly associates with beta-catenin and plakoglobin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Genomic sequencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

A new human pleomorphic hepatocellular carcinoma cell line, KYN-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

p21ras is modified by a farnesyl isoprenoid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

All ras proteins are polyisoprenylated but only some are palmitoylated

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Cadherin dysfunction in a human cancer cell line: possible involvement of loss of alpha-catenin expression in reduced cell-cell adhesiveness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927130

5 July 2018

Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12359056

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor growth and metastasis of human colorectal cancer cell lines in SCID mice resemble clinical metastatic behaviors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12359056

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

1 reference

https://pubmed.ncbi.nlm.nih.gov/12359056

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1349-7006.2002.TB02479.X

1 reference

Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5927130

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5927130

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 June 2018

http://europepmc.org/abstract/PMC/5927130

ResearchGate publication ID

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