Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo (Q34082542)

30 July 2017

title

Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo (English)

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30 July 2017

Chao SH

1

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30 July 2017

Price DH

series ordinal

2

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30 July 2017

language of work or name

English

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publication date

28 June 2001

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Journal of Biological Chemistry

30 July 2017

published in

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30 July 2017

volume

276

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30 July 2017

issue

34

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30 July 2017

page(s)

31793-31799

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Preclinical and clinical development of cyclin-dependent kinase modulators

30 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

Flavopiridol inhibits P-TEFb and blocks HIV-1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

A Novel CDK9-Associated C-Type Cyclin Interacts Directly with HIV-1 Tat and Mediates Its High-Affinity, Loop-Specific Binding to TAR RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

Identification of multiple cyclin subunits of human P-TEFb

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

Tat transactivation: a model for the regulation of eukaryotic transcriptional elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

Highly divergent lentiviral Tat proteins activate viral gene expression by a common mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

Host-cell positive transcription elongation factor b kinase activity is essential and limiting for HIV type 1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

Ribosomal RNA synthesis in isolated nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

Effects of transcription and translation inhibitors on a human gastric carcinoma cell line. Potential role of Bcl-X(S) in apoptosis triggered by these inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

CDK9 (PITALRE): a multifunctional cdc2-related kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

Structure-activity relationship studies of flavopiridol analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102306200

21 January 2018

Identifiers

DOI

10.1074/JBC.M102306200

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30 July 2017

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