Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia (Q34075585)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12136128%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

title

Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia (English)

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11 November 2019

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11 November 2019

author name string

William A Lubas

2

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11 November 2019

Robert C Cooksey

3

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11 November 2019

Mark Hazel

4

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11 November 2019

Glendon J Parker

5

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11 November 2019

Dona C Love

6

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11 November 2019

John A Hanover

7

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11 November 2019

language of work or name

English

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publication date

22 July 2002

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Proceedings of the National Academy of Sciences of the United States of America

11 November 2019

published in

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11 November 2019

volume

99

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11 November 2019

issue

16

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11 November 2019

page(s)

10695-10699

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Hexosamines regulate leptin production in 3T3-L1 adipocytes through transcriptional mechanisms

11 November 2019

cites work

1 reference

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Regulation of leptin production

5 July 2018

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Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site

5 July 2018

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Glycan-dependent signaling: O-linked N-acetylglucosamine

5 July 2018

1 reference

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O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability

5 July 2018

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Glycosylation of nucleocytoplasmic proteins: signal transduction and O-GlcNAc

5 July 2018

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Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain

5 July 2018

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Hexosamines regulate leptin production in human subcutaneous adipocytes

5 July 2018

1 reference

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Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

5 July 2018

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Transgenic mice with increased hexosamine flux specifically targeted to beta-cells exhibit hyperinsulinemia and peripheral insulin resistance

5 July 2018

1 reference

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Obesity and insulin resistance

5 July 2018

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O-Glycosylation of nuclear and cytosolic proteins. Dynamic interplay between O-GlcNAc and O-phosphate

5 July 2018

1 reference

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Perspective: Hexosamines and nutrient sensing

5 July 2018

1 reference

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The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny

5 July 2018

1 reference

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Functional expression of O-linked GlcNAc transferase. Domain structure and substrate specificity

5 July 2018

1 reference

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Glucosamine regulation of glucose metabolism in cultured human skeletal muscle cells: divergent effects on glucose transport/phosphorylation and glycogen synthase in non-diabetic and type 2 diabetic subjects

5 July 2018

1 reference

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Nutritional regulation of leptin in humans

5 July 2018

1 reference

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Mechanism of hexosamine-induced insulin resistance in transgenic mice overexpressing glutamine:fructose-6-phosphate amidotransferase: decreased glucose transporter GLUT4 translocation and reversal by treatment with thiazolidinedione.

5 July 2018

1 reference

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A nutrient-sensing pathway regulates leptin gene expression in muscle and fat.

5 July 2018

1 reference

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Role of the glucosamine pathway in fat-induced insulin resistance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125016

Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility

5 July 2018

1 reference

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O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125016

Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125016

Development of insulin resistance in 3T3-L1 adipocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125016

Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus

5 July 2018

1 reference

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Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125016

Hexosamines and insulin resistance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125016

Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity

5 July 2018

1 reference

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Glutamine:fructose-6-phosphate amidotransferase activity in cultured human skeletal muscle cells: relationship to glucose disposal rate in control and non-insulin-dependent diabetes mellitus subjects and regulation by glucose and insulin

5 July 2018

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In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats

5 July 2018

1 reference

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O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation

5 July 2018

1 reference

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The subcellular distribution of terminal N-acetylglucosamine moieties. Localization of a novel protein-saccharide linkage, O-linked GlcNAc.

5 July 2018

1 reference

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Monoclonal antibodies identify a group of nuclear pore complex glycoproteins

5 July 2018

1 reference

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Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance

5 July 2018

1 reference

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Glucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cells

5 July 2018

1 reference

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Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation

5 July 2018

1 reference

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Reciprocity between O-GlcNAc and O-phosphate on the carboxyl terminal domain of RNA polymerase II.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125016

Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125016

Hexosamines stimulate leptin production in transgenic mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125016

Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles. Study of mechanisms in muscle and in rat-1 fibroblasts overexpressing the human insulin receptor

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125016

Elevated O-linked N-acetylglucosamine metabolism in pancreatic beta-cells

28 October 2018

1 reference

12 December 2020

Glucosamine activates the plasminogen activator inhibitor 1 gene promoter through Sp1 DNA binding sites in glomerular mesangial cells

1 reference

12 December 2020

Retinal VEGF mRNA measured by SYBR green I fluorescence: A versatile approach to quantitative PCR

1 reference

12 December 2020

Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc

1 reference

12 December 2020

O-linked N-acetylglucosamine is attached to proteins of the nuclear pore. Evidence for cytoplasmic and nucleoplasmic glycoproteins

1 reference

12 December 2020

1 reference

12 December 2020

The tissue concentration of UDP-N-acetylglucosamine modulates the stimulatory effect of insulin on skeletal muscle glucose uptake

1 reference

12 December 2020

Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.152346899

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12136128%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

0 references

1 reference

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11 November 2019

PubMed publication ID

12136128

1 reference