Molecular mechanisms of apoptosis induced by cytotoxic chemicals (Q34072607)

30 July 2017

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title

Molecular mechanisms of apoptosis induced by cytotoxic chemicals (English)

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30 July 2017

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2

Orrenius S

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30 July 2017

Robertson JD

1

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30 July 2017

language of work or name

English

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publication date

1 September 2000

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Critical Reviews in Toxicology

30 July 2017

published in

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30 July 2017

volume

30

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30 July 2017

issue

5

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30 July 2017

page(s)

609-627

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

30 July 2017

cites work

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Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

21 January 2018

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Apoptosis: unmasking the executioner

21 January 2018

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Morphological and biochemical characterization and analysis of apoptosis

21 January 2018

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Apoptosis in the pathogenesis and treatment of disease

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Intracellular ATP, a switch in the decision between apoptosis and necrosis.

21 January 2018

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Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis

21 January 2018

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Proteasome activities decrease during dexamethasone-induced apoptosis of thymocytes

21 January 2018

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Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

21 January 2018

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Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA.

21 January 2018

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Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria.

21 January 2018

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Mitochondria and apoptosis

21 January 2018

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Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

21 January 2018

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

21 January 2018

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Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts

21 January 2018

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The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event

21 January 2018

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Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis

21 January 2018

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Human ICE/CED-3 protease nomenclature

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

21 January 2018

Caspases: enemies within

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https://api.crossref.org/works/10.1080%2F10408440008951122

Caspases: killer proteases

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

Caspases: their intracellular localization and translocation during apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Molecular characterization of mitochondrial apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.

21 January 2018

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Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

FADD/MORT1, a signal transducer that can promote cell death or cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Pro-caspase-3 is a major physiologic target of caspase-8.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Caspases induce cytochrome c release from mitochondria by activating cytosolic factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

Genetic control of programmed cell death in the nematode C. elegans.

21 January 2018

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Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

BCL-2 family: regulators of cell death

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

Bax in Murine Thymus Is a Soluble Monomeric Protein That Displays Differential Detergent-induced Conformations

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

The Bcl-2 protein family: arbiters of cell survival

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

BCL-2 family members and the mitochondria in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Bcl-2-family proteins: the role of the BH3 domain in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Regulated targeting of BAX to mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Channel formation by antiapoptotic protein Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Aryl hydrocarbon receptor-mediated signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Lesions of Aryl-hydrocarbon Receptor–deficient Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

A direct interaction between the aryl hydrocarbon receptor and retinoblastoma protein. Linking dioxin signaling to the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Drug-metabolizing enzymes in ligand-modulated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Dioxins: model chemicals for assessing receptor-mediated toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) kills glucocorticoid-sensitive thymocytes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Evidence for the induction of apoptosis in thymocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Overexpression of the anti-apoptotic oncogene, bcl-2, in the thymus does not prevent thymic atrophy induced by estradiol or 2,3,7, 8-tetrachlorodibenzo-p-dioxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Aryl hydrocarbon receptor regulation of ceramide-induced apoptosis in murine hepatoma 1c1c7 cells. A function independent of aryl hydrocarbon receptor nuclear translocator

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

The Ah receptor is not involved in 2,3,7,8-tetrachlorodibenzo- p-dioxin-mediated apoptosis in human leukemic T cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Apoptosis in Daudi human B cells in response to benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

In vitro and in vivo studies on the degradation of metallothionein

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

Long-term observations on tubular and glomerular function in cadmium-exposed persons

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

Effects of zinc and cadmium on apoptotic DNA fragmentation in isolated bovine liver nuclei

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

bcl-2 expression decreases methyl mercury-induced free-radical generation and cell killing in a neural cell line

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

Low-level methylmercury exposure causes human T-cells to undergo apoptosis: evidence of mitochondrial dysfunction

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

Cytochrome c release and caspase activation in hydrogen peroxide- and tributyltin-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Tributyltin increases cytosolic free Ca2+ concentration in thymocytes by mobilizing intracellular Ca2+, activating a Ca2+ entry pathway, and inhibiting Ca2+ efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Role of mitochondria and calcium ions in tributyltin-induced gene regulatory pathways

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

Inhibition of apoptosis by antioxidants in the human HL-60 leukemia cell line

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

Bcl-2 protects from oxidative damage and apoptotic cell death without interfering with activation of NF-kappa B by TNF.

21 January 2018

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Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma

21 January 2018

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Modulation of the toxicity and macromolecular binding of benzene metabolites by NAD(P)H:Quinone oxidoreductase in transfected HL-60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Genetics of programmed cell death in C. elegans: past, present and future.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440008951122

Inhibition of human caspases by peptide-based and macromolecular inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

An intercalation inhibitor altering the target selectivity of DNA damaging agents: Synthesis of site-specific aflatoxin B 1 adducts in a p53 mutational hotspot

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

Cell death induced by topoisomerase-targeted drugs: more questions than answers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440008951122

10.1080/10408440008951122

21 January 2018

Identifiers

DOI

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30 July 2017

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