HDAC6 inhibition restores ciliary expression and decreases tumor growth (Q34035361)

30 July 2017

title

HDAC6 inhibition restores ciliary expression and decreases tumor growth (English)

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30 July 2017

Sergio A Gradilone

1

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30 July 2017

Brynn N Radtke

2

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30 July 2017

Pamela S Bogert

3

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30 July 2017

Bing Q Huang

4

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30 July 2017

Gabriella B Gajdos

5

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30 July 2017

Nicholas F LaRusso

6

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30 July 2017

language of work or name

English

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publication date

31 January 2013

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30 July 2017

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30 July 2017

volume

73

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30 July 2017

issue

7

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30 July 2017

page(s)

2259-2270

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Up-regulation of microRNA 506 leads to decreased Cl-/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis.

30 July 2017

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5 July 2018

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Cholangiocyte N-Ras protein mediates lipopolysaccharide-induced interleukin 6 secretion and proliferation

5 July 2018

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Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells

5 July 2018

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GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment.

5 July 2018

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The Role of HDAC6 in Cancer

5 July 2018

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VHL inactivation induces HEF1 and Aurora kinase A

5 July 2018

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A smac mimetic reduces TNF related apoptosis inducing ligand (TRAIL)-induced invasion and metastasis of cholangiocarcinoma cells

5 July 2018

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Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia.

5 July 2018

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Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A

5 July 2018

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GLI3-dependent repression of DR4 mediates hedgehog antagonism of TRAIL-induced apoptosis

5 July 2018

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Primary cilia are decreased in breast cancer: analysis of a collection of human breast cancer cell lines and tissues

5 July 2018

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5 July 2018

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Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD.

5 July 2018

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A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells

5 July 2018

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The primary cilium at a glance

5 July 2018

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Primary ciliogenesis defects are associated with human astrocytoma/glioblastoma cells

5 July 2018

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NFkappaB p50-CCAAT/enhancer-binding protein beta (C/EBPbeta)-mediated transcriptional repression of microRNA let-7i following microbial infection

5 July 2018

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Gli1 maintains cell survival by up-regulating IGFBP6 and Bcl-2 through promoter regions in parallel manner in pancreatic cancer cells

5 July 2018

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Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis

5 July 2018

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Dual and opposing roles of primary cilia in medulloblastoma development

5 July 2018

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Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma

5 July 2018

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Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia

5 July 2018

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Human cholangiocarcinoma development is associated with dysregulation of opioidergic modulation of cholangiocyte growth.

5 July 2018

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The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.

5 July 2018

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Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors

5 July 2018

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HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

5 July 2018

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Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally

5 July 2018

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5 July 2018

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5 July 2018

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HEF1-dependent Aurora A activation induces disassembly of the primary cilium

5 July 2018

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Dual blockade of the Hedgehog and ERK1/2 pathways coordinately decreases proliferation and survival of cholangiocarcinoma cells

5 July 2018

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Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression

5 July 2018

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Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling

5 July 2018

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Primary cilium formation requires von hippel-lindau gene function in renal-derived cells

5 July 2018

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The primary cilium in cell signaling and cancer

5 July 2018

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Aberrant expression of histone deacetylase 6 in oral squamous cell carcinoma

5 July 2018

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erbB-2/neu transformed rat cholangiocytes recapitulate key cellular and molecular features of human bile duct cancer

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3768151

The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3768151

Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors.

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3768151

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3768151

Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3768151

A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3768151

The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3768151

Bcl-2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell line

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3768151

Establishment and characterization of a human combined hepatocholangiocarcinoma cell line and its heterologous transplantation in nude mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3768151

A new human cholangiocellular carcinoma cell line (HuCC-T1) producing carbohydrate antigen 19/9 in serum-free medium

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3768151

Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3768151

Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3768151

10.1158/0008-5472.CAN-12-2938

29 October 2018

Identifiers

DOI

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30 July 2017

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30 July 2017

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