Curcumin Induces EGFR Degradation in Lung Adenocarcinoma and Modulates p38 Activation in Intestine: The Versatile Adjuvant for Gefitinib Therapy (Q34000044)

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scientific article published on August 17, 2011

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English	Curcumin Induces EGFR Degradation in Lung Adenocarcinoma and Modulates p38 Activation in Intestine: The Versatile Adjuvant for Gefitinib Therapy	scientific article published on August 17, 2011

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scholarly article

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Europe PubMed Central

PubMed publication ID

30 July 2017

Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: the versatile adjuvant for gefitinib therapy (English)

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PubMed publication ID

30 July 2017

Curcumin Induces EGFR Degradation in Lung Adenocarcinoma and Modulates p38 Activation in Intestine: The Versatile Adjuvant for Gefitinib Therapy (English)

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10.1371/JOURNAL.PONE.0023756

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0023756

10 December 2024

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Huei-Wen Chen

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30 July 2017

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Sung-Liang Yu

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10 December 2024

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Pan-Chyr Yang

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10 December 2024

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Jen-Yi Lee

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30 July 2017

Yee-Ming Lee

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30 July 2017

Gee-Chen Chang

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30 July 2017

Wan-Yu Hsieh

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30 July 2017

Jeremy J. W. Chen

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10 December 2024

Huei-Wen Chen

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17 August 2011

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30 July 2017

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10 December 2024

https://europepmc.org/articles/PMC3157465

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https://europepmc.org/articles/PMC3157465?pdf=render

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10 December 2024

http://dx.plos.org/10.1371/journal.pone.0023756

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10.1371/JOURNAL.PONE.0023756

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0023756

10 December 2024

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Europe PubMed Central

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30 July 2017

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Europe PubMed Central

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30 July 2017

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30 July 2017

e23756

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30 July 2017

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Creative Commons Attribution 4.0 International

17 August 2011

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Global cancer statistics

1 reference

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5 July 2018

Curcumin Protects Intestinal Mucosal Barrier Function of Rat Enteritis via Activation of MKP-1 and Attenuation of p38 and NF-κB Activation

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Cancer statistics, 2010

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5 July 2018

The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition

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5 July 2018

Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease

1 reference

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5 July 2018

Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model

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Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets

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Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance

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Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel

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5 July 2018

Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R.

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Role of curcumin in cancer therapy

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Epidermal growth factor receptor signaling modulates apoptosis via p38alpha MAPK-dependent activation of Bax in intestinal epithelial cells

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Molecular targets of curcumin

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Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress

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5 July 2018

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

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Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.

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Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cance

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5 July 2018

Comparison of oxaliplatin- and curcumin-mediated antiproliferative effects in colorectal cell lines

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Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation

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Curcumin: getting back to the roots.

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Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)

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Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation

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Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis

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Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins

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Chemopreventive and therapeutic effects of curcumin

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Reduction of PTEN protein and loss of epidermal growth factor receptor gene mutation in lung cancer with natural resistance to gefitinib (IRESSA).

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Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

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Gefitinib ("Iressa"): a new therapy for advanced non-small-cell lung cancer

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EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

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EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

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Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage.

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Therapeutic potential of curcumin in human prostate cancer. II. Curcumin inhibits tyrosine kinase activity of epidermal growth factor receptor and depletes the protein

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5 July 2018

Transcriptional activation of the hepatocyte growth factor receptor (c-met) gene by its ligand (hepatocyte growth factor) is mediated through AP-1.

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Curcumin inhibits tyrosine kinase activity of p185neu and also depletes p185neu

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Effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cells.

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Selection of Invasive and Metastatic Subpopulations from a Human Lung Adenocarcinoma Cell Line

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Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

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5 July 2018

Good response to gefitinib in lung adenocarcinoma of complex epidermal growth factor receptor (EGFR) mutations with the classical mutation pattern

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Anti-invasive gene expression profile of curcumin in lung adenocarcinoma based on a high throughput microarray analysis.

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21 January 2018

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Curcumin is a potent broad spectrum inhibitor of matrix metalloproteinase gene expression in human astroglioma cells

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21 January 2018

Gefitinib and chemotherapy combination studies in five novel human non small cell lung cancer xenografts. Evidence linking EGFR signaling to gefitinib antitumor response.

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Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1

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12 December 2020

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Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis

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12 December 2020

based on heuristic

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HER3 and mutant EGFR meet MET

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https://pubmed.ncbi.nlm.nih.gov/21858220

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small Cell Lung Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21858220

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21858220

12 December 2020

based on heuristic

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Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21858220

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21858220

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0023756

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

2011PLoSO...623756L

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

ResearchGate publication ID

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