Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6. (Q33997220)

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31 January 2020

title

Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6 (English)

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3

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author name string

Michaela Liedtke

1

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31 January 2020

Paul M Ayton

2

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31 January 2020

Kevin S Smith

4

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31 January 2020

Michael L Cleary

5

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31 January 2020

language of work or name

English

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publication date

15 April 2010

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31 January 2020

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31 January 2020

volume

116

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31 January 2020

issue

1

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page(s)

63-70

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A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription

31 January 2020

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The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling

28 July 2018

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28 July 2018

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The AF-6 Homolog Canoe Acts as a Rap1 Effector During Dorsal Closure of the Drosophila Embryo

28 July 2018

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Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias

28 July 2018

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Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner

28 July 2018

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Transcriptional activation is a key function encoded by MLL fusion partners

28 July 2018

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AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1.

28 July 2018

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Common mechanism for oncogenic activation of MLL by forkhead family proteins

28 July 2018

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The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10.

28 July 2018

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Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

28 July 2018

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The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis

28 July 2018

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28 July 2018

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The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin

28 July 2018

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M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6

28 July 2018

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The Oncogenic Capacity of HRX-ENL Requires the Transcriptional Transactivation Activity of ENL and the DNA Binding Motifs of HRX

28 July 2018

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The Ras Target AF-6 Interacts with ZO-1 and Serves as a Peripheral Component of Tight Junctions in Epithelial Cells

28 July 2018

1 reference

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Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction

28 July 2018

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Three-dimensional structure of the Ras-interacting domain of RalGDS

28 July 2018

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Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL

28 July 2018

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Regulation of cone cell formation by Canoe and Ras in the developing Drosophila eye.

28 July 2018

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Biochemical characterization of a novel KRAS insertion mutation from a human leukemia

28 July 2018

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Analysis of the t(6;11)(q27;q23) in leukemia shows a consistent breakpoint in AF6 in three patients and in the ML-2 cell line

28 July 2018

1 reference

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Incidence and characterization of MLL gene (11q23) rearrangements in acute myeloid leukemia M1 and M5.

28 July 2018

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Identification of AF-6 and canoe as putative targets for Ras.

28 July 2018

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PHD--an automatic mail server for protein secondary structure prediction

28 July 2018

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The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

28 July 2018

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canoe encodes a novel protein containing a GLGF/DHR motif and functions with Notch and scabrous in common developmental pathways in Drosophila

28 July 2018

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AF-6/cno: neither a kinesin nor a myosin, but a bit of both.

28 July 2018

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The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

28 July 2018

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Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

28 July 2018

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A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias

28 July 2018

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A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification

28 July 2018

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Definitive hematopoiesis requires the mixed-lineage leukemia gene

29 October 2018

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The small oligomerization domain of gephyrin converts MLL to an oncogene

29 October 2018

1 reference

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Dimerization of MLL fusion proteins immortalizes hematopoietic cells

29 October 2018

1 reference

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The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2904581

MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function

29 October 2018

1 reference

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The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast

29 October 2018

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A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL.

29 October 2018

1 reference

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Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2904581

Identification of Ce-AF-6, a novel Caenorhabditis elegans protein, as a putative Ras effector

29 October 2018

1 reference

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Defects in yolk sac hematopoiesis in Mll-null embryos

29 October 2018

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Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation

29 October 2018

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The t(6;11)(q27;q23) translocation in acute leukemia: a laboratory and clinical study of 30 cases. EU Concerted Action 11q23 Workshop participants

29 October 2018

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12 December 2020

Recognizing and defining true Ras binding domains I: biochemical analysis

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12 December 2020

Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice

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12 December 2020

Molecular analysis of the rearranged genome and chimeric mRNAs caused by the t(6;11)(q27;q23) chromosome translocation involving MLL in an infant acute monocytic leukemia

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12 December 2020

Recurrent involvement of the MLL gene in adult T-lineage acute lymphoblastic leukemia

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12 December 2020

10.1182/BLOOD-2009-09-243386

Identifiers

DOI

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31 January 2020

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31 January 2020

PubMed publication ID

20395419

1 reference