Antibody humanization: a case of the 'Emperor's new clothes'? (Q33984483)

30 July 2017

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title

Antibody humanization: a case of the 'Emperor's new clothes'? (English)

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30 July 2017

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Clark M

1

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30 July 2017

publication date

1 August 2000

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30 July 2017

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30 July 2017

volume

21

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30 July 2017

issue

8

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30 July 2017

page(s)

397-402

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Continuous cultures of fused cells secreting antibody of predefined specificity

30 July 2017

cites work

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7 January 2021

Advantages of rat monoclonal antibodies

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Somatic generation of antibody diversity

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Production of functional chimaeric mouse/human antibody

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Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains

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Reshaping human antibodies for therapy

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REMISSION INDUCTION IN NON-HODGKIN LYMPHOMA WITH RESHAPED HUMAN MONOCLONAL ANTIBODY CAMPATH-1H

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Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice

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The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor

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7 January 2021

The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties

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Recombinant human IgG molecules lacking Fcgamma receptor I binding and monocyte triggering activities

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Novel cross-reactive anti-idiotype antibodies with properties close to the human intravenous immunoglobulin (IVIg).

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7 January 2021

Replacing the complementarity-determining regions in a human antibody with those from a mouse

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A humanized antibody that binds to the interleukin 2 receptor

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Reshaping a therapeutic CD4 antibody

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Making antibodies by phage display technology

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Mimicking somatic hypermutation: affinity maturation of antibodies displayed on bacteriophage using a bacterial mutator strain

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Human antibody production in transgenic mice: expression from 100 kb of the human IgH locus

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7 January 2021

Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice

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7 January 2021

Tolerance to rat monoclonal antibodies. Implications for serotherapy

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Non-structural determinants of immunogenicity and the B cell co-receptors, CD19, CD21, and CD22

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Enhanced molecular mimicry of CEA using photoaffinity crosslinked C3d peptide

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7 January 2021

Tolerance, danger, and the extended family

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7 January 2021

The human immunoglobulin VH repertoire

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7 January 2021

Sequence and evolution of the human germline V lambda repertoire

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7 January 2021

The structural repertoire of the human V kappa domain

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7 January 2021

Anti-globulin responses to rat and humanized CAMPATH-1 monoclonal antibody used to treat transplant rejection

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7 January 2021

Kabat Database and its applications: 30 years after the first variability plot

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7 January 2021

Uses of chimaeric antibodies

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7 January 2021

10.1016/S0167-5699(00)01680-7

Identifiers

DOI

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30 July 2017

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