Recombinant in vitro tools to predict drug metabolism and safety (Q33856594)

29 July 2017

title

Recombinant in vitro tools to predict drug metabolism and safety (English)

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29 July 2017

Friedberg I I

1

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29 July 2017

publication date

1 March 2000

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Pharmaceutical science & technology today

29 July 2017

published in

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29 July 2017

volume

3

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29 July 2017

issue

3

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29 July 2017

page(s)

99-105

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Human cytochromes P450: problems and prospects

29 July 2017

cites work

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The importance of pharmacokinetic and receptor studies in drug safety evaluation

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Influence of extracellular matrix overlay on phenobarbital-mediated induction of CYP2B1, 2B2, and 3A1 genes in primary adult rat hepatocyte culture

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7 January 2021

Hepatocyte proliferation in vitro: its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix

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7 January 2021

Human cell lines, derived from AHH-1 TK+/- human lymphoblasts, genetically engineered for expression of cytochromes P450.

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V79 Chinese hamster cells genetically engineered for cytochrome P450 and their use in mutagenicity and metabolism studies

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Functional high level expression of cytochrome P450 CYP2D6 using baculoviral expression systems.

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Drug metabolism by Escherichia coli expressing human cytochromes P450

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Yeast expression of animal and plant P450s in optimized redox environments

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Specificity of human UDP-glucuronosyltransferases and xenobiotic glucuronidation

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Truncated Human P450 2D6P: Expression in Escherichia coli, Ni2+-Chelate Affinity Purification, and Characterization of Solubility and Aggregation

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A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding

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Analysis of Four Residues within Substrate Recognition Site 4 of Human Cytochrome P450 3A4: Role in Steroid Hydroxylase Activity and α-Naphthoflavone Stimulation

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Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in Escherichia coli.

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A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1.

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Molecular engineering of microsomal P450 2a-4 to a stable, water-soluble enzyme.

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7 January 2021

Human cytochrome P450 3A4: enzymatic properties of a purified recombinant fusion protein containing NADPH-P450 reductase

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Characterization of enzyme activities and cofactors involved in bioactivation and bioinactivation of chemical carcinogens in the tester strains Escherichia coli K12 MX100 and Salmonella typhimurium LT2 TA100.

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Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation.

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DRUG-INDUCED CHANGES IN THE LIVER ENDOPLASMIC RETICULUM: ASSOCIATION WITH DRUG-METABOLIZING ENZYMES

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7 January 2021

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

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7 January 2021

Sulfotransferase-mediated activation of mutagens studied using heterologous expression systems

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7 January 2021

Evaluation of transcriptional fusions with green fluorescent protein versus luciferase as reporters in bacterial mutagenicity tests

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7 January 2021

10.1016/S1461-5347(00)00243-1

Identifiers

DOI

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release_lvhopegs35ajhp4e5qzi6wztae

29 July 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/lvhopegs35ajhp4e5qzi6wztae

24 November 2022

mapped directly with Wikidata item

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