The transferrin receptor: role in health and disease (Q33785145)

29 July 2017

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title

The transferrin receptor: role in health and disease (English)

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29 July 2017

P Ponka

1

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29 July 2017

C N Lok

series ordinal

2

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29 July 2017

publication date

1 October 1999

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International Journal of Biochemistry & Cell Biology

29 July 2017

published in

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29 July 2017

volume

31

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29 July 2017

issue

10

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29 July 2017

page(s)

1111-1137

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The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells

29 July 2017

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Comparative nutrition of iron and copper

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7 January 2021

Transferrin in a cockroach: molecular cloning, characterization, and suppression by juvenile hormone

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7 January 2021

Cockroach transferrin closely resembles vertebrate transferrins in its metal ion-binding properties: a spectroscopic study.

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7 January 2021

Mosquito transferrin, an acute-phase protein that is up-regulated upon infection

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7 January 2021

A structurally novel transferrin-like protein accumulates in the plasma membrane of the unicellular green alga Dunaliella salina grown in high salinities

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7 January 2021

Iron uptake by the halotolerant alga Dunaliella is mediated by a plasma membrane transferrin

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7 January 2021

Transfer of iron from serum iron-binding protein to human reticulocytes

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7 January 2021

Molecular characteristics of the transferrin-receptor complex of the rabbit reticulocyte

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7 January 2021

Identification of the transferrin receptor of the rabbit reticulocyte

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7 January 2021

Reticulocyte membrane transferrin receptors

1 reference

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7 January 2021

Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin

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7 January 2021

Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin

1 reference

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7 January 2021

The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence

1 reference

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7 January 2021

Primary structure of human transferrin receptor deduced from the mRNA sequence

1 reference

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7 January 2021

Identification of the O-linked glycosylation site of the human transferrin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Functional analysis of human/chicken transferrin receptor chimeras indicates that the carboxy-terminal region is important for ligand binding

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

The transmembrane segment of the human transferrin receptor functions as a signal peptide.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Foreign transmembrane peptides replacing the internal signal sequence of transferrin receptor allow its translocation and membrane binding

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Endocytosis of the transferrin receptor requires the cytoplasmic domain but not its phosphorylation site

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Hemin inhibits internalization of transferrin by reticulocytes and promotes phosphorylation of the membrane transferrin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

A point mutation in the cytoplasmic domain of the transferrin receptor inhibits endocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Structural model of phospholipid-reconstituted human transferrin receptor derived by electron microscopy

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Transferrin receptor: its biological significance

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Functional expression of the human transferrin receptor cDNA in Chinese hamster ovary cells deficient in endogenous transferrin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Transferrin-receptor-independent but iron-dependent proliferation of variant Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

The effect of the iron saturation of transferrin on its binding and uptake by rabbit reticulocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

A new role for the transferrin receptor in the release of iron from transferrin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

1 reference

7 January 2021

Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Iterative endocytosis of transferrin by K562 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Two Distinct Kinds of Tubular Organelles Involved in the Rapid Recycling and Slow Processing of Endocytosed Transferrin

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https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Oxidative stress leads to a rapid alteration of transferrin receptor intravesicular trafficking.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Transferrin receptor is necessary for development of erythrocytes and the nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Exogenous transferrin is taken up and localized by the neurulation-stage mouse embryo in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Acquired Iron-Deficiency Anemia Caused by an Antibody against the Transferrin Receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Gene transfer, expression, and molecular cloning of the human transferrin receptor gene.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Human transferrin receptor: expression of the receptor is assigned to chromosome 3

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Expression of human transferrin receptor is controlled by a gene on chromosome 3: assignment using species specificity of a monoclonal antibody

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Exon/intron structure of the human transferrin receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

New DNA polymorphisms define ethnically distinct haplotypes in the human transferrin receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Iron regulation of transferrin receptor mRNA levels requires iron-responsive elements and a rapid turnover determinant in the 3' untranslated region of the mRNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Transcriptional regulation by iron of the gene for the transferrin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Two genetic loci participate in the regulation by iron of the gene for the human transferrin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Cell proliferation and expression of the transferrin receptor gene: promoter sequence homologies and protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

A mitogen-responsive promoter region that is synergistically activated through multiple signalling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Sequential expression of genes involved in human T lymphocyte growth and differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

SV40 activates transcription from the transferrin receptor promoter by inducing a factor which binds to the CRE/AP-1 recognition sequence

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Transcriptional inactivation of c-myc and the transferrin receptor in dibutyryl cyclic AMP-treated HL-60 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Transcriptional regulation of transferrin receptor expression during phorbol-ester-induced HL-60 cell differentiation. Evidence for a negative regulatory role of the phorbol-ester-responsive element-like sequence

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Regulation of transferrin receptor mRNA expression. Distinct regulatory features in erythroid cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Complex regulation of transferrin receptors during erythropoietin-induced differentiation of J2E erythroid cells--elevated transcription and mRNA stabilisation produce only a modest rise in protein content

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Deletional analysis of the promoter region of the human transferrin receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

A DNA-binding activity, TRAC, specific for the TRA element of the transferrin receptor gene copurifies with the Ku autoantigen

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Iron-dependent regulation of ferritin and transferrin receptor expression by the iron-responsive element binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Iron regulatory elements (IREs): a family of mRNA non-coding sequences

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Regulating the fate of mRNA: the control of cellular iron metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Iron Regulates the Intracellular Degradation of Iron Regulatory Protein 2 by the Proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Redox signaling: nitrosylation and related target interactions of nitric oxide

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Iron regulatory protein 1 is not required for the modulation of ferritin and transferrin receptor expression by iron in a murine pro-B lymphocyte cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Oxidative stress induces activation of a cytosolic protein responsible for control of iron uptake.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Rapid responses to oxidative stress mediated by iron regulatory protein.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Nitric oxide and oxidative stress (H2O2) control mammalian iron metabolism by different pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra- and intracellular oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Activation of iron regulatory protein-1 by oxidative stress in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Ribonucleotide reductases

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Specific membrane receptors for diferric-transferrin in cultured rat skeletal myocytes and chick-embryo cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Transferrin binds specifically to pachytene spermatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Transferrin receptors in human tissues: their distribution and possible clinical relevance

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Expression of transferrin receptor on murine hematopoietic progenitors

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Transferrin receptors and iron uptake during erythroid cell development

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Haemoglobin Synthesis in Erythropoietin‐Stimulated J2E Cells Does not Require Increased Numbers of Transferrin Receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Inducibility of Transferrin Receptors on Friend Erythroleukemic Cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Friend erythroleukemia cell membrane transferrin receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Control of heme synthesis during Friend cell differentiation: role of iron and transferrin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Loss of the transferrin receptor during the maturation of sheep reticulocytes in vitro. An immunological approach

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Gene expression in proliferating human erythroid cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Hemin regulates the expression of transferrin receptors in human hematopoietic cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Regulation of iron metabolism: translational effects mediated by iron, heme, and cytokines

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Biosynthesis of the transferrin receptor in rabbit reticulocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Expression and loss of the transferrin receptor in growing and differentiating HD3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Inhibition of heme synthesis decreases transferrin receptor expression in mouse erythroleukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Expression of the transferrin receptor on murine peritoneal macrophages is modulated by in vitro treatment with interferon gamma

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Nitric oxide and macrophage function

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Transferrin receptor induction in mitogen-stimulated human T lymphocytes is required for DNA synthesis and cell division and is regulated by interleukin 2

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Post-transcriptional regulation of the transferrin receptor and 4F2 antigen heavy chain mRNA during growth activation of spleen cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Replacement of transferrin in serum-free cultures of mitogen-stimulated mouse lymphocytes by a lipophilic iron chelator

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Evidence that transferrin supports cell proliferation by supplying iron for DNA synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Inhibition of proliferation and differentiation during early T cell development by anti-transferrin receptor antibody

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Induction of T cell activation by monoclonal antibodies specific for the transferrin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Cleavage of the transferrin receptor by human granulocytes: differential proteolysis of the exosome-bound TFR

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Serum transferrin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

The transferrin receptor: its diagnostic value and its potential as therapeutic target

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Diagnostic utility of serum transferrin receptors measurement in assessing iron status.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Kupffer cell staining by an HFE-specific monoclonal antibody: implications for hereditary haemochromatosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: implications for cellular iron homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Rab15 mediates an early endocytic event in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Identification of a hypoxia response element in the transferrin receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Increased expression of transferrin receptors and iron in amoeboid microglial cells in postnatal rats following an exposure to hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

Control of transferrin receptor expression via nitric oxide-mediated modulation of iron-regulatory protein 2.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2899%2900070-9

7 January 2021

10.1016/S1357-2725(99)00070-9

Identifiers

DOI

1 reference

29 July 2017

1 reference