Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66 (Q33768527)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944737%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

title

Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66 (English)

1 reference

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20 March 2020

1 reference

5

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20 March 2020

Alessandro Bonifazi

6

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20 March 2020

Jeffrey R. Deschamps

7

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20 March 2020

author name string

Vivek Kumar

1

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20 March 2020

Ashwini K Banala

2

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20 March 2020

Erick G Garcia

3

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20 March 2020

Jianjing Cao

4

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20 March 2020

Amy Hauck Newman

8

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20 March 2020

publication date

24 March 2014

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ACS Medicinal Chemistry Letters

20 March 2020

published in

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20 March 2020

volume

5

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20 March 2020

issue

6

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20 March 2020

page(s)

647-651

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Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug design

20 March 2020

cites work

1 reference

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A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors.

22 June 2018

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22 June 2018

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Medication discovery for addiction: translating the dopamine D3 receptor hypothesis

22 June 2018

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Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

22 June 2018

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Higher binding of the dopamine D3 receptor-preferring ligand [11C]-(+)-propyl-hexahydro-naphtho-oxazin in methamphetamine polydrug users: a positron emission tomography study.

22 June 2018

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N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity

22 June 2018

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Recent advances in the development of dopamine D3 receptor antagonists: a medicinal chemistry perspective.

22 June 2018

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Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

22 June 2018

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Current perspectives on selective dopamine D(3) receptor antagonists as pharmacotherapeutics for addictions and related disorders

22 June 2018

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Rearrangement of beta-amino alcohols via aziridiniums: a review

22 June 2018

1 reference

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N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists

22 June 2018

1 reference

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Dopamine: 50 years in perspective

22 June 2018

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Dopamine and drug addiction: the nucleus accumbens shell connection.

22 June 2018

1 reference

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Dopamine receptors: from structure to function

22 June 2018

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22 June 2018

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Asymmetric Catalysis with Water: Efficient Kinetic Resolution of Terminal Epoxides by Means of Catalytic Hydrolysis

30 October 2018

1 reference

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Adaptive increase in D3 dopamine receptors in the brain reward circuits of human cocaine fatalities

22 June 2018

2 references

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22 June 2018

https://pubmed.ncbi.nlm.nih.gov/24944737

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Localization of dopamine D3 receptors to mesolimbic and D2 receptors to mesostriatal regions of human forebrain

1 reference

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Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.

22 June 2018

1 reference

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Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype

30 October 2018

1 reference

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30 October 2018

Identifiers

DOI

10.1021/ML500006V

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20 March 2020

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20 March 2020

PubMed publication ID

24944737

1 reference

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