Senescent cells: a novel therapeutic target for aging and age-related diseases (Q33732761)

29 July 2017

1 reference

title

Senescent cells: a novel therapeutic target for aging and age-related diseases (English)

1 reference

29 July 2017

R M Naylor

1

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29 July 2017

D J Baker

series ordinal

2

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29 July 2017

J M van Deursen

series ordinal

3

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29 July 2017

language of work or name

English

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publication date

5 December 2012

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Clinical Pharmacology & Therapeutics

29 July 2017

published in

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29 July 2017

volume

93

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29 July 2017

issue

1

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29 July 2017

page(s)

105-116

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Identification, proliferation, and differentiation of adult Leydig stem cells

29 July 2017

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21 June 2018

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21 June 2018

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21 June 2018

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

21 June 2018

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Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging

21 June 2018

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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

21 June 2018

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CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control

21 June 2018

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Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer

21 June 2018

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Cancer and ageing: convergent and divergent mechanisms

21 June 2018

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21 June 2018

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Cellular senescence: when bad things happen to good cells

21 June 2018

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21 June 2018

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The intersection of cancer and aging: establishing the need for breast cancer rehabilitation

21 June 2018

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21 June 2018

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 June 2018

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A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

21 June 2018

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Cellular senescence in the glaucomatous outflow pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

The pathogenesis of chronic obstructive pulmonary disease: advances in the past 100 years

21 June 2018

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Rejuvenation of aged progenitor cells by exposure to a young systemic environment

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Idiopathic pulmonary fibrosis: challenges and opportunities for the clinician and investigator

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Ink4a/Arf expression is a biomarker of aging

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

The serial cultivation of human diploid cell strains

21 June 2018

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Alzheimer Disease in the US Population

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Tumor cell senescence in cancer treatment

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

21 June 2018

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21 June 2018

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Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction

21 June 2018

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Characterization of regulatory elements on the promoter region of p16(INK4a) that contribute to overexpression of p16 in senescent fibroblasts

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

21 June 2018

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Deletion of Ku86 causes early onset of senescence in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

21 June 2018

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The INK4A/ARF locus and its two gene products

21 June 2018

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Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

21 June 2018

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Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

21 June 2018

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4051295

Hayflick, his limit, and cellular ageing

21 June 2018

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Ink4a/Arf expression is a biomarker of aging

21 January 2018

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Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

21 January 2018

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BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a

21 January 2018

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RPE cell senescence: a key contributor to age-related macular degeneration.

21 January 2018

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The pathobiology of Parkinson's disease: biochemical aspects of dopamine neuron senescence

21 January 2018

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Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

30 October 2018

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Cigarette smoke induces senescence in alveolar epithelial cells

30 October 2018

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12 December 2020

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

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A crucial role for adipose tissue p53 in the regulation of insulin resistance

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The role of chondrocyte senescence in osteoarthritis

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Identifiers

DOI

10.1038/CLPT.2012.193

1 reference

29 July 2017

1 reference

29 July 2017

1 reference