The role of CYP2B6 in human xenobiotic metabolism (Q33719834)

28 July 2017

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title

The role of CYP2B6 in human xenobiotic metabolism (English)

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28 July 2017

1

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28 July 2017

S A Wrighton

2

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28 July 2017

language of work or name

English

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publication date

1 August 1999

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28 July 2017

published in

Drug Metabolism Reviews

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28 July 2017

volume

31

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28 July 2017

issue

3

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28 July 2017

page(s)

719-754

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Isolation and sequence of a human cytochrome P-450 cDNA clone

28 July 2017

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Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages

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cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver

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21 January 2018

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Examination of purported probes of human CYP2B6.

21 January 2018

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7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes

21 January 2018

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A continuous fluorometric assay for cytochrome P-450-dependent mixed function oxidases using 3-cyano-7-ethoxycoumarin

21 January 2018

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Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

21 January 2018

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Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4.

21 January 2018

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Identification of the human and animal hepatic cytochromes P450 involved in clonazepam metabolism

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450.

21 January 2018

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Age-dependent expression of cytochrome P-450s in rat liver

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

Species and sex differences of testosterone and nifedipine oxidation in liver microsomes of rat, dog and monkey

21 January 2018

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Regiochemistry of cytochrome P450 isozymes

21 January 2018

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The role of cytochrome P450 3A (CYP3A) isoform(s) in oxidative metabolism of testosterone and benzphetamine in human adult and fetal liver

21 January 2018

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Catalytic characteristics of CYP3A4: requirement for a phenolic function in ortho hydroxylation of estradiol and mono-O-demethylated methoxychlor

21 January 2018

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The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4.

21 January 2018

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Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

21 January 2018

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CO binding kinetics of human cytochrome P450 3A4. Specific interaction of substrates with kinetically distinguishable conformers.

21 January 2018

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Why are enzymes less active in organic solvents than in water?

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

Understanding enzymic catalysis: the importance of short, strong hydrogen bonds

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

Identification of a functional water channel in cytochrome P450 enzymes.

21 January 2018

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Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes

21 January 2018

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Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes

21 January 2018

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Ring hydroxylation of [o-3H]methoxychlor as a probe for liver microsomal CYP2B activity: potential for in vivo CYP2B assay.

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

In vitro metabolism of aflatoxin B1 by normal and tumorous liver tissue from Thailand.

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

Dissecting the function of cytochrome P450.

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

Inhibitory monoclonal antibody to human cytochrome P450 2B6.

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

In vitro methods for assessing human hepatic drug metabolism: their use in drug development

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

The human hepatic cytochromes P450 involved in drug metabolism

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

Analysis of Human Cytochrome P450 Catalytic Activities and Expression

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Immunohistochemistry of drug-metabolizing enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Molecular genetics of the human cytochrome P450-dependent monooxygenases.

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

Regulation of cytochrome P450 gene expression in human colon and breast tumour xenografts

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

Site-Directed Mutagenesis as a Tool for Molecular Modeling of Cytochrome P450 2B1

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

Computer modeling of 3D structures of cytochrome P450s

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

Construction and evaluation of a three-dimensional structure of cytochrome P450choP enzyme (CYP105C1).

21 January 2018

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Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

Scanning tunneling microscopy study of cytochrome P450 2B4 incorporated in proteoliposomes

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryo-electron microscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

X-ray Structure of Bacteriorhodopsin at 2.5 Angstroms from Microcrystals Grown in Lipidic Cubic Phases

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

Steady State Enzyme Velocities That Are Independent of [Enzyme]: An Important Behavior in Many Membrane and Particle-Bound States

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

Reductionism. The ends of understanding.

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100101942

Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Molecular biology of human xenobiotic-metabolizing cytochromes P450: role of vaccinia virus cDNA expression in evaluating catalytic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450- expressing human liver cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Cytochrome P450 species involved in the metabolism of quinoline

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Roles of different forms of cytochrome P450 in the activation of the promutagen 6-aminochrysene to genotoxic metabolites in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Activation of trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene to genotoxic metabolites by rat and human cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

The role of 12 cDNA-expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans-7,8-dihydrodiol

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Stereospecific activation of the procarcinogen benzo[a]pyrene: a probe for the active sites of the cytochrome P450 superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: evidence for major roles by cytochromes P450 2A6 and 2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Metabolism of carteolol by cDNA-expressed human cytochrome P450

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Metabolism of highly persistent PCB congener, 2,4,5,2',4',5'-hexachlorobiphenyl, by human CYP2B6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Metabolism of n-hexane by rat liver and extrahepatic tissues and the effect of cytochrome P-450 inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Human Kidney Methoxyflurane and Sevoflurane Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Regio- and stereo-selective metabolism of phenanthrene by twelve cDNA-expressed human, rodent, and rabbit cytochromes P-450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Metabolism of a new local anesthetic, ropivacaine, by human hepatic cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Species differences in the covalent binding of [14C]tamoxifen to liver microsomes and the forms of cytochrome P450 involved

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Toluene metabolism by cDNA-expressed human hepatic cytochrome P450

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Oxidative metabolism of flunarizine and cinnarizine by microsomes from B-lymphoblastoid cell lines expressing human cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Role of cDNA-expressed human cytochromes P450 in the metabolism of diazepam

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Expression of cytochrome P450 and microsomal epoxide hydrolase in cervical and oral epithelial cells immortalized by human papillomavirus type 16 E6/E7 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Comparative studies on coumarin and testosterone metabolism in mouse and human livers

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Re-expression of C/EBPα induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

Differences in the chemical reactivity of individual molecules of an enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100101942

21 January 2018

Identifiers

DOI

10.1081/DMR-100101942

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28 July 2017

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