Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality. (Q33712882)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585933%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

title

Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality (English)

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20 December 2019

2

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20 December 2019

author name string

Michael H Woo

1

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20 December 2019

Hong Guo

3

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20 December 2019

Luca Pattarello

4

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20 December 2019

Piero Benedetti

5

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20 December 2019

Mary-Ann Bjornsti

6

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20 December 2019

language of work or name

English

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publication date

29 October 2003

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

20 December 2019

published in

1 reference

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20 December 2019

volume

100

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20 December 2019

issue

24

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20 December 2019

page(s)

13767-13772

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DNA relaxation by human topoisomerase I occurs in the closed clamp conformation of the protein

20 December 2019

cites work

1 reference

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Non-reciprocal regulation of the redox state of the glutathione-glutaredoxin and thioredoxin systems

21 June 2018

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Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

21 June 2018

1 reference

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Cancer therapeutics in yeast

21 June 2018

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Cellular roles of dna topoisomerases: a molecular perspective

21 June 2018

1 reference

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Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin

21 June 2018

1 reference

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DNA topoisomerases: structure, function, and mechanism

21 June 2018

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Tumor cell death induced by topoisomerase-targeting drugs.

21 June 2018

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Molecular and biological determinants of the cytotoxic actions of camptothecins. Perspective for the development of new topoisomerase I inhibitors

21 June 2018

1 reference

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Mechanism of action of camptothecin

21 June 2018

1 reference

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Clinical use of topoisomerase I inhibitors in anticancer treatment

21 June 2018

1 reference

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Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structures

21 June 2018

1 reference

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Conservation of Structure and Mechanism between Eukaryotic Topoisomerase I and Site-Specific Recombinases

21 June 2018

1 reference

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A Model for the Mechanism of Human Topoisomerase I

21 June 2018

1 reference

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Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA

21 June 2018

1 reference

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DNA transport by a type II topoisomerase: direct evidence for a two-gate mechanism

21 June 2018

1 reference

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Intradimerically tethered DNA topoisomerase II is catalytically active in DNA transport

21 June 2018

1 reference

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Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro-camptothecin

21 June 2018

1 reference

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SCT1 mutants suppress the camptothecin sensitivity of yeast cells expressing wild-type DNA topoisomerase I

21 June 2018

1 reference

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Supercoiling of intracellular DNA can occur in eukaryotic cells.

21 June 2018

1 reference

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Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.

21 June 2018

1 reference

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Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate.

21 January 2018

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Vascular factors in cognitive impairment--where are we now?

21 January 2018

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Enzymes that push DNA around

21 January 2018

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Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme

21 January 2018

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Intragenic suppressors of mutant DNA topoisomerase I-induced lethality diminish enzyme binding of DNA

21 January 2018

1 reference

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Increased Camptothecin Toxicity Induced in Mammalian Cells Expressing Saccharomyces cerevisiae DNA Topoisomerase I

21 January 2018

1 reference

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Alterations in the catalytic activity of yeast DNA topoisomerase I result in cell cycle arrest and cell death

21 January 2018

1 reference

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Reconstitution of enzymatic activity by the association of the cap and catalytic domains of human topoisomerase I

21 January 2018

1 reference

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Translating the knowledge of molecular alterations that occur during colon carcinogenesis into clinically relevant solutions

21 January 2018

1 reference

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Camptothecin resistance from a single mutation changing glycine 363 of human DNA topoisomerase I to cysteine

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/14585933

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.2235886100

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585933%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

0 references

1 reference

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20 December 2019

PubMed publication ID

14585933

1 reference