Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3 (Q33643763)

28 July 2017

title

Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3 (English)

1 reference

28 July 2017

Hiroyasu Nakano

5

0 references

author name string

András Masszi

1

1 reference

28 July 2017

Pam Speight

2

1 reference

28 July 2017

Emmanuel Charbonney

3

1 reference

28 July 2017

Monika Lodyga

4

1 reference

28 July 2017

Katalin Szászi

6

1 reference

28 July 2017

András Kapus

7

1 reference

28 July 2017

language of work or name

English

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publication date

1 February 2010

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28 July 2017

published in

Journal of Cell Biology

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28 July 2017

volume

188

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28 July 2017

issue

3

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28 July 2017

page(s)

383-399

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Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe.

28 July 2017

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Interaction of Smad3 and SRF-associated complex mediates TGF-beta1 signals to regulate SM22 transcription during myofibroblast differentiation

21 June 2018

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21 June 2018

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Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

21 June 2018

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Actin dynamics control SRF activity by regulation of its coactivator MAL

21 June 2018

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21 June 2018

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Epithelial to mesenchymal transition in Madin-Darby canine kidney cells is accompanied by down-regulation of Smad3 expression, leading to resistance to transforming growth factor-beta-induced growth arrest.

21 June 2018

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21 June 2018

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Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-beta-induced fibronectin in mesangial cells

21 June 2018

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21 June 2018

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21 June 2018

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TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3

21 June 2018

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Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis

21 June 2018

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Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor

21 June 2018

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Alteration of transforming growth factor-beta1 response involves down-regulation of Smad3 signaling in myofibroblasts from skin fibrosis

21 June 2018

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Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

21 June 2018

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Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

21 June 2018

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21 June 2018

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Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

21 June 2018

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Induction of apoptosis by Smad3 and down-regulation of Smad3 expression in response to TGF-beta in human normal lung epithelial cells

21 June 2018

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Smad3 mutant mice develop metastatic colorectal cancer

21 June 2018

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Myofibroblasts differentiate from fibroblasts when plated at low density

21 June 2018

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Identification of transcriptional activation and inhibitory domains in serum response factor (SRF) by using GAL4-SRF constructs

21 June 2018

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The smooth muscle alpha-actin gene promoter is differentially regulated in smooth muscle versus non-smooth muscle cells

21 June 2018

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The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

21 June 2018

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MKL1 mediates TGF-beta1-induced alpha-smooth muscle actin expression in human renal epithelial cells

21 June 2018

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Crossref

https://api.crossref.org/works/10.1083%2FJCB.200906155

Regulation of Smad3 expression in bleomycin-induced pulmonary fibrosis: a negative feedback loop of TGF-beta signaling

21 January 2018

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Crossref

https://api.crossref.org/works/10.1083%2FJCB.200906155

Transforming growth factor-beta-induced inhibition of myogenesis is mediated through Smad pathway and is modulated by microtubule dynamic stability

21 January 2018

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https://api.crossref.org/works/10.1083%2FJCB.200906155

Quantitation of actin polymerization in two human fibroblast sub-types responding to mechanical stretching

21 January 2018

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12 December 2020

SRF is a nuclear repressor of Smad3-mediated TGF-beta signaling

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12 December 2020

Cell phenotype-specific down-regulation of Smad3 involves decreased gene activation as well as protein degradation

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12 December 2020

TGF-beta receptor expression and smad2 localization are cell density dependent in fibroblasts

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12 December 2020

Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGFbeta signal transduction during transdifferentiation of hepatic

1 reference

12 December 2020

Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition

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12 December 2020

Identifiers

DOI

10.1083/JCB.200906155

1 reference

28 July 2017

1 reference

28 July 2017

1 reference