BACE1 and BACE2 enzymatic activities in Alzheimer's disease (Q33643141)

28 July 2017

title

BACE1 and BACE2 enzymatic activities in Alzheimer's disease (English)

1 reference

28 July 2017

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Rachel R Ahmed

1

1 reference

28 July 2017

Christopher J Holler

2

1 reference

28 July 2017

Robin L Webb

3

1 reference

28 July 2017

Feng Li

4

1 reference

28 July 2017

Tina L Beckett

5

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28 July 2017

M Paul Murphy

6

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28 July 2017

language of work or name

English

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publication date

4 December 2009

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Journal of Neurochemistry

28 July 2017

published in

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28 July 2017

volume

112

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28 July 2017

issue

4

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28 July 2017

page(s)

1045-1053

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Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease

28 July 2017

cites work

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21 June 2018

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BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome

21 June 2018

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21 June 2018

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21 June 2018

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Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes

21 June 2018

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Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

21 June 2018

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Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region

21 June 2018

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Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

21 June 2018

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21 June 2018

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21 June 2018

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BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 June 2018

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 June 2018

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21 June 2018

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ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

21 June 2018

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BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 June 2018

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21 June 2018

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21 June 2018

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The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

21 June 2018

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 June 2018

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 June 2018

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21 June 2018

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21 June 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 June 2018

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Apolipoprotein E, a Gene with Complex Biological Interactions in the Aging Brain

21 June 2018

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Apolipoprotein E affects the rate of Alzheimer disease expression: beta-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease

21 June 2018

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21 June 2018

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21 June 2018

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

21 June 2018

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Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional beta-secretase candidate(s).

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819564

Protein expression of BACE1, BACE2 and APP in Down syndrome brains

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819564

Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice

30 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819564

Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis

30 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819564

Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819564

Chromosome 21 BACE2 haplotype associates with Alzheimer's disease: a two-stage study

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819564

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819564

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819564

Gamma-secretase: substrates and inhibitors

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819564

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819564

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819564

Elevated expression of beta-site amyloid precursor protein cleaving enzyme 2 in brains of patients with Down syndrome

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819564

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819564

Coordinated Expression of β-Amyloid Precursor Protein and the Putative β-Secretase BACE and α-Secretase ADAM10 in Mouse and Human Brain

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19968762

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19968762

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19968762

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1471-4159.2009.06528.X

1 reference

28 July 2017

1 reference

28 July 2017

1 reference