Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage. (Q33615689)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28508041%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

title

Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage (English)

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20 March 2020

0 references

2

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20 March 2020

Nick Kassouf

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20 March 2020

Majid Hafezparast

4

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20 March 2020

Sherif Faruk El-Khamisy

7

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20 March 2020

author name string

Shih-Chieh Chiang

1

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20 March 2020

Peter J McKinnon

5

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20 March 2020

Rachel Haywood

6

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20 March 2020

publication date

28 April 2017

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20 March 2020

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20 March 2020

volume

3

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20 March 2020

issue

4

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20 March 2020

page(s)

e1602506

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Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan

20 March 2020

cites work

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21 June 2018

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Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.

21 June 2018

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21 June 2018

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Tracking the processing of damaged DNA double-strand break ends by ligation-mediated PCR: increased persistence of 3'-phosphoglycolate termini in SCAN1 cells

21 June 2018

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TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy

21 June 2018

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Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I.

21 June 2018

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ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells

21 June 2018

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Two-dimensional intact mitochondrial DNA agarose electrophoresis reveals the structural complexity of the mammalian mitochondrial genome.

21 June 2018

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A kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity

21 June 2018

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21 June 2018

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21 June 2018

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TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

21 June 2018

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Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites

21 June 2018

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21 June 2018

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21 June 2018

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To live or to die: a matter of processing damaged DNA termini in neurons

21 June 2018

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Chronically elevated glucose compromises myocardial mitochondrial DNA integrity by alteration of mitochondrial topoisomerase function

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation

21 June 2018

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TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo

21 June 2018

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21 June 2018

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21 June 2018

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Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages

21 June 2018

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21 June 2018

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21 June 2018

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Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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8-Oxoguanine rearranges the active site of human topoisomerase I

21 June 2018

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Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

21 June 2018

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Human mitochondrial topoisomerase I

21 June 2018

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Topoisomerase I-mediated DNA damage

21 June 2018

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Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells

21 June 2018

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Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine

21 June 2018

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Ionizing radiation stimulates mitochondrial gene expression and activity

21 June 2018

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Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

21 June 2018

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Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

21 June 2018

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Hypernegative supercoiling of the DNA template during transcription elongation in vitro.

21 June 2018

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21 June 2018

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Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

21 June 2018

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Hydroxyl radical formation by UV-irradiated epidermal cells

21 June 2018

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Friction and torque govern the relaxation of DNA supercoils by eukaryotic topoisomerase IB.

21 June 2018

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Mitochondrial dysfunction in fibroblasts derived from patients with Niemann-Pick type C disease.

21 January 2018

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Protein, lipid, and DNA radicals to measure skin UVA damage and modulation by melanin

21 January 2018

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Hydroxyl radical generation caused by the reaction of singlet oxygen with a spin trap, DMPO, increases significantly in the presence of biological reductants

21 January 2018

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Chemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin

21 January 2018

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A tyrosyl DNA phosphodiesterase 1 from kinetoplastid parasite Leishmania donovani (LdTdp1) capable of removing topo I-DNA covalent complexes

21 January 2018

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Detection of Covalent DNA-Bound Spo11 and Topoisomerase Complexes

30 October 2018

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12 December 2020

UVA radiation-induced oxidative damage to lipids and proteins in vitro and in human skin fibroblasts is dependent on iron and singlet oxygen

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12 December 2020

The SOD1 transgene in the G93A mouse model of amyotrophic lateral sclerosis lies on distal mouse chromosome 12

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The structural basis of camptothecin interactions with human serum albumin: impact on drug stability

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12 December 2020

Intensity-dependent direct solar radiation- and UVA-induced radical damage to human skin and DNA, lipids and proteins

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Expression profile and mitochondrial colocalization of Tdp1 in peripheral human tissues

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Measuring sunscreen protection against solar-simulated radiation-induced structural radical damage to skin using ESR/spin trapping: development of an ex vivo test method

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Identifiers

DOI

10.1126/SCIADV.1602506

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28508041%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28508041%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

PubMed publication ID

28508041

1 reference