The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma. (Q33607950)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28350342%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

title

The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28350342%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

main subject

acute myeloid leukemia

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28350342%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Kristian Bowles

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28350342%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Stuart A Rushworth

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28350342%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

author name string

Rachel E Piddock

1

1 reference

28 July 2017

Kristian M Bowles

2

1 reference

28 July 2017

Stuart A Rushworth

3

1 reference

28 July 2017

publication date

28 March 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28350342%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28350342%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

volume

9

1 reference

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14 March 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28350342%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

14 March 2020

copyright license

start time

28 March 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

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21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5406704

Heat shock protein expression independently predicts clinical outcome in prostate cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5406704

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5406704

PIK3CA as an oncogene in cervical cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5406704

Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5406704

Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5406704

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5406704

Chemokine SDF-1 enhances circulating CD34(+) cell proliferation in synergy with cytokines: possible role in progenitor survival.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5406704

Regulation of neuronal survival by the serine-threonine protein kinase Akt

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5406704

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5406704

Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5406704

Substrate specificities and identification of a putative binding site for PI3K in the carboxy tail of the murine Flt3 receptor tyrosine kinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5406704

Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5406704

Participation of the cytokines interleukin 6, tumor necrosis factor-alpha, and interleukin 1-beta secreted by acute myelogenous leukemia blasts in autocrine and paracrine leukemia growth control

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5406704

Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells

21 June 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

The PIK3CA gene is mutated with high frequency in human breast cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

Frequent mutation of the PIK3CA gene in ovarian and breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

PI3K-dependent multiple myeloma cell survival is mediated by the PIK3CA isoform.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

MIF-Induced Stromal PKCβ/IL8 Is Essential in Human Acute Myeloid Leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

Bone marrow stromal-derived soluble factors and direct cell contact contribute to de novo drug resistance of myeloma cells by distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

Functional regulation of D-type cyclins by insulin-like growth factor-I and serum in multiple myeloma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

Interleukin-6 activates PI3K/Akt pathway and regulates cyclin A1 to promote prostate cancer cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

Effects of IL-8 Up-Regulation on Cell Survival and Osteoclastogenesis in Multiple Myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

Correlation of the survival of ovarian cancer patients with mRNA expression of the 60-kD heat-shock protein HSP-60.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

Increased antileukemic effects in human acute myeloid leukemia by combining HSP70 and HSP90 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

Inhibition of the PI3K-Akt signaling pathway reduces tumor necrosis factor-alpha production in response to titanium particles in vitro

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5406704

Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5406704

Molecular monitoring of minimal residual disease in patients in long-term complete remission after allogeneic stem cell transplantation for multiple myeloma

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5406704

Whole exome sequencing identifies driver mutations in asymptomatic computed tomography-detected lung cancers with normal karyotype

30 October 2018

1 reference

https://api.crossref.org/works/10.3390%2FCANCERS9040029

High percentage of CD34-positive cells in autologous AML peripheral blood stem cell products reflects inadequate in vivo purging and low chemotherapeutic toxicity in a subgroup of patients with poor clinical outcome

21 January 2018

1 reference

12 December 2020

FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group

1 reference

12 December 2020

Prognostic value of minimal residual disease in relapsed childhood acute lymphoblastic leukaemia

1 reference

12 December 2020

Migratory behavior of leukemic cells from acute myeloid leukemia patients

1 reference

12 December 2020

Human acute myeloid leukaemia cells express adhesion proteins and bind to bone marrow fibroblast monolayers and extracellular matrix proteins

1 reference

12 December 2020

Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes

1 reference

12 December 2020

Serum levels of interleukin-6 in multiple myeloma and other hematological disorders: correlation with disease activity and other prognostic parameters

1 reference

12 December 2020

A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16

1 reference

12 December 2020

Immunophenotyping investigation of minimal residual disease is a useful approach for predicting relapse in acute myeloid leukemia patients

1 reference

12 December 2020

ERK/MAPK-dependent PI3K/Akt phosphorylation through VEGFR-1 after VEGF stimulation in activated hepatic stellate cells

1 reference

12 December 2020

The essential cells of the hemopoietic microenvironment

1 reference

12 December 2020

Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia

1 reference

12 December 2020

Identifiers

DOI

10.3390/CANCERS9040029

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28350342%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28350342%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference