Antisense pharmacodynamics: critical issues in the transport and delivery of antisense oligonucleotides (Q33607807)

28 July 2017

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title

Antisense pharmacodynamics: critical issues in the transport and delivery of antisense oligonucleotides (English)

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28 July 2017

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Juliano RL

1

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28 July 2017

Alahari S

2

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28 July 2017

Yoo H

3

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28 July 2017

Kole R

4

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28 July 2017

Cho M

5

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28 July 2017

publication date

1 April 1999

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28 July 2017

published in

Pharmaceutical Research

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28 July 2017

volume

16

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28 July 2017

issue

4

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28 July 2017

page(s)

494-502

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Pharmacokinetics and biodistribution of a nucleotide-based thrombin inhibitor in rats

28 July 2017

cites work

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12 December 2020

Inhibition of expression of the multidrug resistance-associated P-glycoprotein of by phosphorothioate and 5' cholesterol-conjugated phosphorothioate antisense oligonucleotides

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12 December 2020

Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid

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12 December 2020

In vivo studies with antisense oligonucleotides

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12 December 2020

Pharmacokinetics of Oligonucleotides

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12 December 2020

Oligodeoxyribonucleotide uptake in primary human hematopoietic cells is enhanced by cationic lipids and depends on the hematopoietic cell subset

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12 December 2020

Up-regulation of luciferase gene expression with antisense oligonucleotides: implications and applications in functional assay development

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12 December 2020

Integrin receptor-targeted transfer peptides for efficient delivery of antisense oligodeoxynucleotides

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12 December 2020

The activity of c-myb antisense oligonucleotide to prevent intimal hyperplasia is nonspecific

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12 December 2020

Intracellular distribution of microinjected antisense oligonucleotides

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12 December 2020

The third helix of the Antennapedia homeodomain translocates through biological membranes.

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12 December 2020

Cell adhesion and drug resistance in cancer

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12 December 2020

Repair of thalassemic human beta-globin mRNA in mammalian cells by antisense oligonucleotides

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12 December 2020

Perspectives in antisense therapeutics

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12 December 2020

Antisense—Protein Kinase A: A Single-Gene-Based Therapeutic Approach

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12 December 2020

An ICAM-1 antisense oligonucleotide prevents and reverses dextran sulfate sodium-induced colitis in mice

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12 December 2020

Complement activation and hemodynamic changes following intravenous administration of phosphorothioate oligonucleotides in the monkey

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12 December 2020

A good antisense molecule is hard to find

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12 December 2020

Electrophoresis in lyotropic polymer liquid crystals

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12 December 2020

Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers.

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12 December 2020

Inhibition of Herpes Simplex Virus Replication by Antisense Oligo-2'-O-methylribonucleoside Methylphosphonates

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12 December 2020

First- and second-generation antisense inhibitors targeted to human c-raf kinase: in vitro and in vivo studies

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12 December 2020

Progress in antisense oligonucleotide therapeutics

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12 December 2020

A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth

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12 December 2020

Phase I safety and pharmacokinetic profile of an intercellular adhesion molecule-1 antisense oligodeoxynucleotide (ISIS 2302)

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12 December 2020

Cationic lipids, phosphatidylethanolamine and the intracellular delivery of polymeric, nucleic acid-based drugs (review).

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12 December 2020

Liver Uptake of Phosphodiester Oligodeoxynucleotides Is Mediated by Scavenger Receptors

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12 December 2020

Problems in interpretation of data derived from in vitro and in vivo use of antisense oligodeoxynucleotides

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12 December 2020

Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-alpha expression

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12 December 2020

Hepatic distribution and clearance of antisense oligonucleotides in the isolated perfused rat liver

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12 December 2020

Cellular distribution of phosphorothioate oligodeoxynucleotides in normal rodent tissues

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12 December 2020

Mapping of RNA accessible sites for antisense experiments with oligonucleotide libraries

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12 December 2020

In VivoMetabolic Profile of a Phosphorothioate Oligodeoxyribonucleotide

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12 December 2020

Radiolabeling of methylphosphonate and phosphorothioate oligonucleotides and evaluation of their transport in everted rat jejunum sacs

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12 December 2020

Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides

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12 December 2020

Selective inhibition of alpha1B-adrenergic receptor expression and function using a phosphorothioate antisense oligodeoxynucleotide.

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12 December 2020

Comparative pharmacokinetics, tissue distribution, and tumor accumulation of phosphorothioate, phosphorodithioate, and methylphosphonate oligonucleotides in nude mice

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12 December 2020

Effect of Antisense Oligonucleotides against Cholesteryl Ester Transfer Protein on the Development of Atherosclerosis in Cholesterol-fed Rabbits

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12 December 2020

Selecting effective antisense reagents on combinatorial oligonucleotide arrays

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12 December 2020

Antileukemia effect of c-myc N3'-->P5' phosphoramidate antisense oligonucleotides in vivo

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12 December 2020

The effect of oligonucleotides to c-myb on vascular smooth muscle cell proliferation and neointima formation after porcine coronary angioplasty

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12 December 2020

Intracellular routing and inhibitory activity of oligonucleopeptides containing a KDEL motif

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12 December 2020

Pharmacokinetic properties of several novel oligonucleotide analogs in mice

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12 December 2020

An antisense oligonucleotide on the mouse Shaker-like potassium channel Kv1.1 gene prevents antinociception induced by morphine and baclofen

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12 December 2020

Cellular uptake and intracellular fate of antisense oligonucleotides

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12 December 2020

CpG motifs in bacterial DNA trigger direct B-cell activation

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12 December 2020

The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism

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12 December 2020

Tissue architecture: the ultimate regulator of epithelial function?

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12 December 2020

Development of Targeted Delivery Systems for Nucleic Acid Drugs

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12 December 2020

Role of pharmacokinetics and metabolism in drug discovery and development

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12 December 2020

Inhibition of protein kinase C-alpha expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides

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12 December 2020

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry as a rapid quality control method in oligonucleotide synthesis

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12 December 2020

Genetic medicine--when will it come to the drugstore?

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12 December 2020

Antisense oligodeoxyribonucleotides suppress hematologic cell growth through stepwise release of deoxyribonucleotides

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12 December 2020

Clearance kinetics, biodistribution, and organ saturability of phosphorothioate oligodeoxynucleotides in mice

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12 December 2020

Cationic Polyhexylcyanoacrylate Nanoparticles as Carriers for Antisense Oligonucleotides

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12 December 2020

In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells

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12 December 2020

Biodegradable polyalkylcyanoacrylate nanoparticles for the delivery of oligonucleotides

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12 December 2020

On-line HPLC electrospray mass spectrometry of phosphorothioate oligonucleotide metabolites

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12 December 2020

Evaluation of adjuvants that enhance the effectiveness of antisense oligodeoxynucleotides

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12 December 2020

Intercellular trafficking and protein delivery by a herpesvirus structural protein

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12 December 2020

Cationic liposomes coated with polyethylene glycol as carriers for oligonucleotides.

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12 December 2020

2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells.

1 reference

12 December 2020

In vivo distribution and metabolism of a phosphorothioate oligonucleotide within rat liver after intravenous administration.

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12 December 2020

Morpholino antisense oligomers: design, preparation, and properties

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12 December 2020

Phosphorothioate oligodeoxyribonucleotides dissociate from cationic lipids before entering the nucleus

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12 December 2020

How to design an antisense oligodeoxynucleotide experiment: a consensus approach

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12 December 2020

Mechanism of oligonucleotide release from cationic liposomes

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12 December 2020

Antisense oligonucleotides as therapeutic agents--is the bullet really magical?

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12 December 2020

Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence

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12 December 2020

Antisense oligonucleotides: Is the glass half full or half empty?

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12 December 2020

Advances in Understanding the Pharmacological Properties of Antisense Oligonucleotides

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12 December 2020

Synthesis and Characterization of a Peptide Nucleic Acid Conjugated to a d-Peptide Analog of Insulin-like Growth Factor 1 for Increased Cellular Uptake

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12 December 2020

Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: in vitro and in vivo studies

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12 December 2020

Spontaneous and cationic lipid-mediated uptake of antisense oligonucleotides in human monocytes and lymphocytes

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12 December 2020

Antisense drug discovery: can cell-free screens speed the process?

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12 December 2020

Improved biological activity of antisense oligonucleotides conjugated to a fusogenic peptide

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12 December 2020

Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures

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12 December 2020

bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice

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12 December 2020

Identification and partial purification of human double strand RNase activity. A novel terminating mechanism for oligoribonucleotide antisense drugs

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12 December 2020

Transformed and immortalized cellular uptake of oligodeoxynucleoside phosphorothioates, 3′-Alkylamino oligodeoxynucleotides, 2′-o-methyl oligoribonucleotides, oligodeoxynucleoside methylphosphonates, and peptide nucleic acids

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12 December 2020

Pharmacology of Therapeutic Oligonucleotides

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12 December 2020

Mechanism of cellular uptake of modified oligodeoxynucleotides containing methylphosphonate linkages

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12 December 2020

Promise and Problems of Bcl-2 Antisense Therapy

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12 December 2020

Antisense raf oligodeoxyribonucleotide is protected by liposomal encapsulation and inhibits Raf-1 protein expression in vitro and in vivo: implication for gene therapy of radioresistant cancer

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12 December 2020

Polyamidoamine cascade polymers mediate efficient transfection of cells in culture

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12 December 2020

Improving the intracellular delivery and molecular efficacy of antisense oligonucleotides in chronic myeloid leukemia cells: a comparison of streptolysin-O permeabilization, electroporation, and lipophilic conjugation

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12 December 2020

hnRNP proteins and the biogenesis of mRNA

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12 December 2020

Intracellular disposition and metabolism of fluorescently-labeled unmodified and modified oligonucleotides microinjected into mammalian cells

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12 December 2020

An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery

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12 December 2020

Characterization of oligonucleotide metabolism in vivo via liquid chromatography/electrospray tandem mass spectrometry with a quadrupole ion trap mass spectrometer

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12 December 2020

Crohn's trial shows the pros of antisense

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12 December 2020

Characterization of complexes of oligonucleotides with polyamidoamine starburst dendrimers and effects on intracellular delivery

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12 December 2020

Novel chemically modified oligonucleotides provide potent inhibition of P-glycoprotein expression

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12 December 2020

Pharmacokinetics, metabolism, and elimination of a 20-mer phosphorothioate oligodeoxynucleotide (cgp 69846a) after intravenous and subcutaneous administration

1 reference

12 December 2020

Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice

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12 December 2020

Phosphorothioate Oligodeoxynucleotides: Large‐Scale Synthesis and Analysis, Impurity Characterization, and the Effects of Phosphorus Stereochemistry

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12 December 2020

Current concepts in antisense drug design

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12 December 2020

Pharmacokinetics of an antisense oligonucleotide injected intravitreally in monkeys

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12 December 2020

Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction

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12 December 2020

DNA antisense therapy for asthma in an animal model

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12 December 2020

Antisense oligonucleotides as therapeutics for malignant diseases.

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12 December 2020

Analysis of antisense oligonucleotides by capillary electrophoresis, gel-slab electrophoresis, and HPLC: a comparison

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12 December 2020

Developing oligonucleotide therapeutics for human leukemia

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12 December 2020

Identifiers

DOI

10.1023/A:1011958726518

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28 July 2017

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