Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis (Q33597162)

28 July 2017

title

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis (English)

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28 July 2017

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8

Eric Dufour

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28 July 2017

Samuel E Weinberg

2

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Lucas B Sullivan

object named as

Lucas B Sullivan

5

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Gökhan M Mutlu

9

object named as

Gokhan M Mutlu

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28 July 2017

William W Wheaton

1

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28 July 2017

Robert B Hamanaka

3

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28 July 2017

Saul Soberanes

4

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28 July 2017

Elena Anso

6

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28 July 2017

Andrea Glasauer

7

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28 July 2017

Gr Scott Budigner

10

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28 July 2017

Navdeep S Chandel

11

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28 July 2017

language of work or name

English

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publication date

13 May 2014

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28 July 2017

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28 July 2017

volume

3

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28 July 2017

page(s)

e02242

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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

28 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Physiological roles of mitochondrial reactive oxygen species

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Metformin in cancer: translational challenges

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Hypoxia-inducible factors in physiology and medicine

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Metformin reduces endogenous reactive oxygen species and associated DNA damage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Cellular and molecular mechanisms of metformin: an overview

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Reductive carboxylation supports growth in tumour cells with defective mitochondria.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Clinical Pharmacokinetics of Metformin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

The sites and topology of mitochondrial superoxide production

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Permeabilization of cell membranes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Metformin therapy and clinical uses

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Dose translation from animal to human studies revisited

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Metformin and reduced risk of cancer in diabetic patients

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Complex III releases superoxide to both sides of the inner mitochondrial membrane

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Topology of superoxide production from different sites in the mitochondrial electron transport chain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017650

Quantitation and origin of the mitochondrial membrane potential in human cells lacking mitochondrial DNA.

21 June 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02242

Metformin and the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02242

The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin.

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02242

Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson.

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02242

Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02242

Mechanisms underlying saturable intestinal absorption of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02242

Superoxide is produced by the reduced flavin in mitochondrial complex I: a single, unified mechanism that applies during both forward and reverse electron transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02242

Metformin suppresses intestinal polyp growth in ApcMin/+ mice

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02242

Diabetes, Metformin, and Breast Cancer: Lilac Time?

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24843020

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.7554/ELIFE.02242

1 reference

release_y77j5jmgebhdxhgfpmhpyemoya

28 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/y77j5jmgebhdxhgfpmhpyemoya

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

4017650

1 reference

28 July 2017

1 reference