Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice (Q33594383)

28 July 2017

title

Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice (English)

1 reference

28 July 2017

Xiaofeng Gu

1

1 reference

28 July 2017

Erin R Greiner

2

1 reference

28 July 2017

Rakesh Mishra

3

1 reference

28 July 2017

Ravindra Kodali

4

1 reference

28 July 2017

Alex Osmand

5

1 reference

28 July 2017

Steven Finkbeiner

6

1 reference

28 July 2017

Joan S Steffan

7

1 reference

28 July 2017

Leslie Michels Thompson

8

1 reference

28 July 2017

Ronald Wetzel

9

1 reference

28 July 2017

X William Yang

10

1 reference

28 July 2017

language of work or name

English

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publication date

1 December 2009

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28 July 2017

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28 July 2017

volume

64

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28 July 2017

issue

6

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28 July 2017

page(s)

828-840

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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.

28 July 2017

cites work

1 reference

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Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity

21 June 2018

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Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

21 June 2018

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21 June 2018

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Acetylation targets mutant huntingtin to autophagosomes for degradation

21 June 2018

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Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery

21 June 2018

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Progressive synaptic pathology of motor cortical neurons in a BAC transgenic mouse model of Huntington's disease

21 June 2018

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21 June 2018

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Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity

21 June 2018

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Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice

21 June 2018

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21 June 2018

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Behavioral phenotyping strategies for mutant mice

21 June 2018

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Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity

21 June 2018

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21 June 2018

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Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.

21 June 2018

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Trinucleotide Repeat Disorders

21 June 2018

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Multiple pathways contribute to the pathogenesis of Huntington disease

21 June 2018

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21 June 2018

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Flanking sequences profoundly alter polyglutamine toxicity in yeast

21 June 2018

1 reference

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Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity

21 June 2018

1 reference

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Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function

21 June 2018

1 reference

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21 June 2018

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Suppression of Huntington's disease pathology in Drosophila by human single-chain Fv antibodies.

21 June 2018

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Polyglutamine expansion of huntingtin impairs its nuclear export

21 June 2018

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Protein aggregation and neurodegenerative disease

21 June 2018

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Molecular pathways to neurodegeneration

21 June 2018

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Using antibodies to analyze polyglutamine stretches.

21 June 2018

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Experimental therapeutics in transgenic mouse models of Huntington's disease

21 June 2018

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SUMO modification of Huntingtin and Huntington's disease pathology

21 June 2018

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Huntingtin: alive and well and working in middle management

21 June 2018

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Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats

21 June 2018

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Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

21 June 2018

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Huntingtin aggregation and toxicity in Huntington's disease

21 June 2018

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Highly efficient modification of bacterial artificial chromosomes (BACs) using novel shuttle vectors containing the R6Kgamma origin of replication

21 June 2018

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alpha-Synuclein is phosphorylated in synucleinopathy lesions

21 June 2018

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Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

21 June 2018

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Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

21 June 2018

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21 June 2018

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Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807408

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807408

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807408

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 June 2018

1 reference

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Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807408

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807408

14-3-3zeta is indispensable for aggregate formation of polyglutamine-expanded huntingtin protein

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807408

The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807408

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807408

Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807408

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807408

Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807408

Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807408

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807408

Homologous recombination based modification in Esherichia coli and germline transmission in transgenic mice of a bacterial artificial chromsome

30 October 2018

1 reference

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New genes for old diseases: the molecular basis of myotonic dystrophy and Huntington's disease. The Lumleian Lecture 1995.

30 October 2018

1 reference

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Kinetics and thermodynamics of amyloid assembly using a high-performance liquid chromatography-based sedimentation assay

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20064390

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Huntingtin: Alive and Well and Working in Middle Management

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20064390

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NEURON.2009.11.020

1 reference

28 July 2017

1 reference

28 July 2017

1 reference