A phase I clinical trial of the hu14.18-IL2 (EMD 273063) as a treatment for children with refractory or recurrent neuroblastoma and melanoma: a study of the Children's Oncology Group (Q33370628)

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English	A phase I clinical trial of the hu14.18-IL2 (EMD 273063) as a treatment for children with refractory or recurrent neuroblastoma and melanoma: a study of the Children's Oncology Group	scientific article

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18 January 2020

A phase I clinical trial of the hu14.18-IL2 (EMD 273063) as a treatment for children with refractory or recurrent neuroblastoma and melanoma: a study of the Children's Oncology Group (English)

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18 January 2020

phase I clinical trial

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18 January 2020

Katherine K Matthay

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Katherine K Matthay

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18 January 2020

Robert C Seeger

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Robert C Seeger

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18 January 2020

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Kaci L Osenga

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18 January 2020

Jacquelyn A Hank

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18 January 2020

Mark R Albertini

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18 January 2020

Jacek Gan

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18 January 2020

Adam G Sternberg

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18 January 2020

Jens Eickhoff

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18 January 2020

Clare Twist

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18 January 2020

Mark Krailo

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18 January 2020

Peter C Adamson

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18 January 2020

Ralph A Reisfeld

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18 January 2020

Stephen D Gillies

14

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18 January 2020

Paul M Sondel

15

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18 January 2020

Children's Oncology Group

16

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18 January 2020

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1 March 2006

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18 January 2020

Clinical Cancer Research

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18 January 2020

12

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18 January 2020

6

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18 January 2020

1750-1759

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18 January 2020

Phase I clinical trial of the immunocytokine EMD 273063 in melanoma patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587020

21 June 2018

Enhanced activity of hu14.18-IL2 immunocytokine against murine NXS2 neuroblastoma when combined with interleukin 2 therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587020

21 June 2018

What does it take to make a natural killer?

1 reference

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21 June 2018

Determination of Peak Serum Levels and Immune Response to the Humanized Anti-Ganglioside Antibody-Interleukin-2 Immunocytokine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587020

21 June 2018

Progress in human tumour immunology and immunotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587020

21 June 2018

Specific enzyme-linked immunosorbent assays for quantitation of antibody-cytokine fusion proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587020

21 June 2018

Activation of human effector cells by a tumor reactive recombinant anti-ganglioside GD2 interleukin-2 fusion protein (ch14.18-IL2).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587020

21 June 2018

Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587020

21 June 2018

A phase I/IB trial of murine monoclonal anti-GD2 antibody 14.G2a plus interleukin-2 in children with refractory neuroblastoma: a report of the Children's Cancer Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587020

21 June 2018

Electrophysiological characteristics of primary afferent fibers after systemic administration of anti-GD2 ganglioside antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587020

21 June 2018

Long-lived and transferable tumor immunity in mice after targeted interleukin-2 therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587020

21 June 2018

Antibody-interleukin 2 fusion proteins: a new approach to cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587020

21 June 2018

Treatment of neuroblastoma patients with antiganglioside GD2 antibody plus interleukin-2 induces antibody-dependent cellular cytotoxicity against neuroblastoma detected in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587020

21 June 2018

Repetitive weekly cycles of interleukin-2. II. Clinical and immunologic effects of dose, schedule, and addition of indomethacin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587020

21 June 2018

Disialoganglioside GD2 on human neuroblastoma cells: target antigen for monoclonal antibody-mediated cytolysis and suppression of tumor growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587020

21 June 2018

Design and analysis of phase I clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587020

21 June 2018

Augmentation of antibody dependent cell mediated cytotoxicity following in vivo therapy with recombinant interleukin 2.

1 reference

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21 June 2018

Safety, pharmacokinetics, and biological pharmacodynamics of the immunocytokine EMD 273066 (huKS-IL2): results of a phase I trial in patients with prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587020

31 October 2018

NXS2 murine neuroblastomas express increased levels of MHC class I antigens upon recurrence following NK-dependent immunotherapy.

1 reference

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31 October 2018

Activity of iodine-123 metaiodobenzylguanidine in childhood neuroblastoma: lack of relation to tumour differentiation in vivo

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31 October 2018

Pathogenesis of the neurotoxicity caused by anti-GD2 antibody therapy

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31 October 2018

Natural killer cell-mediated eradication of neuroblastoma metastases to bone marrow by targeted interleukin-2 therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16551859

12 December 2020

based on heuristic

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Antibody-dependent cellular cytotoxicity mediated by murine lymphocytes activated in recombinant interleukin 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/16551859

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study of chimeric human/murine anti-ganglioside G(D2) monoclonal antibody (ch14.18) with granulocyte-macrophage colony-stimulating factor in children with neuroblastoma immediately after hematopoietic stem-cell transplantation: a Children's

1 reference

https://pubmed.ncbi.nlm.nih.gov/16551859

12 December 2020

based on heuristic

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Ganglioside gd(2) expression in the human nervous-system and in neuroblastomas - an immunohistochemical study

1 reference

https://pubmed.ncbi.nlm.nih.gov/16551859

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of cellular mechanisms operational in vivo during the regression of established pulmonary metastases by the systemic administration of high-dose recombinant interleukin 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/16551859

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum CD25 levels during interleukin-2 therapy: dose dependence and correlations with clinical toxicity and lymphocyte surface sCD25 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16551859

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase IB trial of chimeric antidisialoganglioside antibody plus interleukin 2 for melanoma patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16551859

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1078-0432.CCR-05-2000

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18 January 2020

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18 January 2020

PubMed publication ID

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18 January 2020

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