Stimulation of chitin synthesis rescues Candida albicans from echinocandins. (Q33326983)

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5 January 2020

title

Stimulation of chitin synthesis rescues Candida albicans from echinocandins (English)

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5 January 2020

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2

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5 January 2020

Irene de Bruijn

3

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5 January 2020

Neil A. R. Gow

6

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5 January 2020

author name string

Louise A Walker

1

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5 January 2020

Megan D Lenardon

4

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5 January 2020

Alastair McKinnon

5

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publication date

4 April 2008

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5 January 2020

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5 January 2020

volume

4

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issue

4

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5 January 2020

page(s)

e1000040

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Creative Commons Attribution 4.0 International

5 January 2020

copyright license

start time

4 April 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall

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Escape of Candida from caspofungin inhibition at concentrations above the MIC (paradoxical effect) accomplished by increased cell wall chitin; evidence for beta-1,6-glucan synthesis inhibition by caspofungin

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Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates

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An interactional network of genes involved in chitin synthesis in Saccharomyces cerevisiae

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Genomic approach to identification of mutations affecting caspofungin susceptibility in Saccharomyces cerevisiae

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Proteomic analysis of Candida albicans cell walls reveals covalently bound carbohydrate-active enzymes and adhesins.

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21 June 2018

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21 June 2018

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Temperature-induced expression of yeast FKS2 is under the dual control of protein kinase C and calcineurin

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Comparison of susceptibility and transcription profile of the new antifungal hassallidin A with caspofungin.

21 June 2018

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The PKC, HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans.

21 January 2018

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21 January 2018

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Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species

21 January 2018

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Chs1 of Candida albicans is an essential chitin synthase required for synthesis of the septum and for cell integrity.

21 January 2018

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Failure of caspofungin to treat brain abscesses secondary to Candida albicans prosthetic valve endocarditis

21 January 2018

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Progressive loss of echinocandin activity following prolonged use for treatment of Candida albicans oesophagitis

21 January 2018

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Progressive esophagitis caused by Candida albicans with reduced susceptibility to caspofungin.

21 January 2018

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Amphotericin B and caspofungin resistance in Candida glabrata isolates recovered from a critically ill patient

21 January 2018

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Development of candidemia on caspofungin therapy: a case report

21 January 2018

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Development of Streptococcus thermophilus lacZ as a reporter gene for Candida albicans

21 January 2018

1 reference

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Characterization of the chitin biosynthesis process as a compensatory mechanism in the fks1 mutant of Saccharomyces cerevisiae

21 January 2018

1 reference

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Regulation of chitin synthesis during dimorphic growth of Candida albicans

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18389063

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of a novel inhibitor specific to the fungal chitin synthase. Inhibition of chitin synthase 1 arrests the cell growth, but inhibition of chitin synthase 1 and 2 is lethal in the pathogenic fungus Candida albicans

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18389063

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PPAT.1000040

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18389063%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18389063%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

PubMed publication ID

18389063

1 reference