Direct screening of a dynamic combinatorial library using mass spectrometry (Q33245172)

24 July 2017

title

Direct screening of a dynamic combinatorial library using mass spectrometry (English)

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24 July 2017

Sally-Ann Poulsen

1

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24 July 2017

publication date

2 June 2006

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Journal of the American Society for Mass Spectrometry

24 July 2017

published in

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24 July 2017

volume

17

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24 July 2017

issue

8

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24 July 2017

page(s)

1074-1080

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describes a project that uses

24 July 2017

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Molecular evolution: dynamic combinatorial libraries, autocatalytic networks and the quest for molecular function

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Dynamic combinatorial carbohydrate libraries: probing the binding site of the concanavalin A lectin

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Target-induced formation of neuraminidase inhibitors from in vitro virtual combinatorial libraries

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Ketones as building blocks for dynamic combinatorial libraries: highly active neuraminidase inhibitors generated via selection pressure of the biological target

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Virtual combinatorial libraries: dynamic generation of molecular and supramolecular diversity by self-assembly

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Amplification of screening sensitivity through selective destruction: theory and screening of a library of carbonic anhydrase inhibitors.

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Generation of bis-cationic heterocyclic inhibitors of Bacillus subtilis HPr kinase/phosphatase from a ditopic dynamic combinatorial library

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Uracil-directed ligand tethering: an efficient strategy for uracil DNA glycosylase (UNG) inhibitor development

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In vitro combinatorial chemistry to create drug candidates

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Mass spectrometry and combinatorial chemistry: a short outline

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Studying noncovalent protein complexes by electrospray ionization mass spectrometry

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Screening derivatized peptide libraries for tight binding inhibitors to carbonic anhydrase II by electrospray ionization-mass spectrometry

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Multiple ion isolation applications in FT-ICR MS: exact-mass MSn internal calibration and purification/interrogation of protein-drug complexes

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Fourier transform-ion cyclotron resonance mass spectrometric resolution, identification, and screening of non-covalent complexes of Hck Src homology 2 domain receptor and ligands from a 324-member peptide combinatorial library

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Influence of solution and gas phase processes on protein-carbohydrate binding affinities determined by nanoelectrospray Fourier transform ion cyclotron resonance mass spectrometry

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Evaluation of automated nano-electrospray mass spectrometry in the determination of non-covalent protein-ligand complexes

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Screening a natural product-based combinatorial library using FTICR mass spectrometry

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Anticancer and antiviral sulfonamides

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Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.

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Carbonic anhydrases: current state of the art, therapeutic applications and future prospects

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Synthesis and structure-activity relationships of novel benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II.

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New mass spectrometric methods for the study of noncovalent associations of biopolymers

21 January 2018

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Using Electrospray Ionization FTICR Mass Spectrometry To Study Competitive Binding of Inhibitors to Carbonic Anhydrase

21 January 2018

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Carbonic Anhydrase Inhibitors: Synthesis and Inhibition of Cytosolic/Membrane-Associated Carbonic Anhydrase Isozymes I, II, and IX with Sulfonamides Incorporating Hydrazino Moieties

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Dynamic combinatorial chemistry: lysozyme selects an aromatic motif that mimics a carbohydrate residue

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12 December 2020

Dynamic deconvolution of a pre-equilibrated dynamic combinatorial library of acetylcholinesterase inhibitors

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Ligand amplification in a dynamic combinatorial glycopeptide library

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Optimizing the reversibility of hydrazone formation for dynamic combinatorial chemistry

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Combination of bovine carbonic anhydrase with a fluorescent sulfonamide

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Catalytic self-screening of cholinesterase substrates from a dynamic combinatorial thioester library

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In situ generation and screening of a dynamic combinatorial carbohydrate library against concanavalin A.

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Application of electrospray ionization mass spectrometry for studying human immunodeficiency virus protein complexes

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Pseudodynamic combinatorial libraries: a receptor-assisted approach for drug discovery

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Fragment-based drug discovery of carbonic anhydrase II inhibitors by dynamic combinatorial chemistry utilizing alkene cross metathesis

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Detection of ligands from a dynamic combinatorial library by X-ray crystallography.

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Characterization of Toxins within Crude Venoms by Combined Use of Fourier Transform Mass Spectrometry and Cloning

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Determination of dissociation constants for protein-ligand complexes by electrospray ionization mass spectrometry

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Dynamic covalent chemistry

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12 December 2020

Using an Enzyme's Active Site To Template Inhibitors This work was supported by the Centre National de la Recherche Scientifique and by the Ecole Polytechnique (predoctoral fellowship to R.N.). We thank Prof. Jean-Marie Lehn for stimulating discussi

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12 December 2020

10.1016/J.JASMS.2006.03.017

Identifiers

DOI

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Dimensions Publication ID

24 July 2017

1014287627

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