Mouse models of human familial cancer syndromes (Q33204054)

23 July 2017

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title

Mouse models of human familial cancer syndromes (English)

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23 July 2017

Jerrold M Ward

1

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23 July 2017

Deborah E Devor-Henneman

series ordinal

2

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23 July 2017

language of work or name

English

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publication date

1 March 2004

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23 July 2017

published in

Toxicologic Pathology

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23 July 2017

volume

32 Suppl 1

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23 July 2017

page(s)

90-98

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Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

23 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Atm-deficient mice: a paradigm of ataxia telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Polycystic kidney disease as a result of loss of the tuberous sclerosis 2 tumor suppressor gene during development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

21 January 2018

Hereditary renal cancers

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Mouse models of tumor development in neurofibromatosis type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Of mice and MEN1: Insulinomas in a conditional mouse knockout

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Knockout mouse models and mammary tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

The nature of the heterozygous Trp53 knockout model for identification of mutagenic carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

APC-dependent suppression of colon carcinogenesis by PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

The Wilms tumor suppressor gene wt1 is required for development of the spleen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Mouse models for colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Effects of an Rb mutation in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

WT-1 is required for early kidney development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Mouse models for human familial adenomatous polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Mutations in the WRN gene in mice accelerate mortality in a p53-null background

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Tumorigenesis in mice carrying a truncating Brca1 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Cancer predisposition caused by elevated mitotic recombination in Bloom mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

RB-mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

MSH2 deficient mice are viable and susceptible to lymphoid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Adenovirus-mediated retinoblastoma gene therapy suppresses spontaneous pituitary melanotroph tumors in Rb+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Role of the INK4a locus in tumor suppression and cell mortality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Minimal effects of dietary restriction on neuroendocrine carcinogenesis in Rb+/- mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Mouse tumor model for neurofibromatosis type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Developmental defects and tumor predisposition in Rb mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

The Wilms' tumor gene Wt1 is required for normal development of the retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

DNA mismatch repair deficiency accelerates endometrial tumorigenesis in Pten heterozygous mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Mouse models for human DNA mismatch-repair gene defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Studying cancer families to identify kidney cancer genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

Neurofibromas in NF1: Schwann cell origin and role of tumor environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230490424680

10.1080/01926230490424680

21 January 2018

Identifiers

DOI

1 reference

23 July 2017

1 reference