Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity (Q30856526)

15 October 2017

Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity (English)

1 reference

15 October 2017

Mireia Duñach

7

0 references

author name string

Imma Raurell

1

1 reference

15 October 2017

Montserrat Codina

2

1 reference

15 October 2017

David Casagolda

3

1 reference

15 October 2017

Beatriz Del Valle

4

1 reference

15 October 2017

Josep Baulida

5

1 reference

15 October 2017

Antonio García de Herreros

6

1 reference

15 October 2017

language of work or name

English

0 references

publication date

30 December 2008

1 reference

15 October 2017

1 reference

15 October 2017

3

1 reference

15 October 2017

12

1 reference

15 October 2017

e4080

1 reference

Creative Commons Attribution 4.0 International

15 October 2017

start time

30 December 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease

21 June 2018

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Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface

21 June 2018

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Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

21 June 2018

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Presenilin-1 interacts with plakoglobin and enhances plakoglobin-Tcf-4 association. Implications for the regulation of beta-catenin/Tcf-4-dependent transcription

21 June 2018

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Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability

21 June 2018

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Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation

21 June 2018

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ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling

21 June 2018

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PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

21 June 2018

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Presenilins in memory, Alzheimer's disease, and therapy

21 June 2018

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Convergence of Wnt, beta-catenin, and cadherin pathways

21 June 2018

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Class II MHC peptide loading by the professionals

21 June 2018

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A core function for p120-catenin in cadherin turnover

21 June 2018

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Tyrosine Phosphorylation of Plakoglobin Causes Contrary Effects on Its Association with Desmosomes and Adherens Junction Components and Modulates β-Catenin-Mediated Transcription

21 June 2018

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A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

Caught up in a Wnt storm: Wnt signaling in cancer

21 June 2018

1 reference

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

21 June 2018

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The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog?

21 June 2018

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Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

21 June 2018

1 reference

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Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

21 June 2018

1 reference

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Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

The transcriptional factor Tcf-4 contains different binding sites for beta-catenin and plakoglobin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

Presenilin 1 independently regulates beta-catenin stability and transcriptional activity

21 June 2018

1 reference

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p300/CBP proteins: HATs for transcriptional bridges and scaffolds

21 June 2018

1 reference

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Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

21 June 2018

1 reference

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Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

Presenilin-dependent gamma-secretase activity modulates thymocyte development

21 June 2018

1 reference

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Alzheimer's disease: genes, proteins, and therapy

21 June 2018

1 reference

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Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

21 June 2018

1 reference

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Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

21 June 2018

1 reference

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Presenilin affects arm/beta-catenin localization and function in Drosophila.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

A screen for mutations that suppress the phenotype of Drosophila armadillo, the beta-catenin homolog.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

21 June 2018

Wnt signaling and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

CBP/p300 in cell growth, transformation, and development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

Plakoglobin suppresses epithelial proliferation and hair growth in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits"

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

The Wnt/Wg signal transducer beta-catenin controls fibronectin expression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

Identification of c-MYC as a target of the APC pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

CREB-binding protein/p300 are transcriptional coactivators of p65

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2603589

Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA.

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004080

Regulation of E-cadherin/Catenin association by tyrosine phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004080

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004080

Regulation of beta-catenin structure and activity by tyrosine phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004080

Amyloid beta inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface NMDA receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004080

The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004080

PS1 knockin mice with the Japanese I213T mutation: effects on exploratory activity, motor coordination, and spatial learning

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004080

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004080

Beta-catenin N- and C-terminal tails modulate the coordinated binding of adherens junction proteins to beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004080

Protein topology of presenilin 1

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19114997

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

beta-Catenin and plakoglobin N- and C-tails determine ligand specificity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19114997

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19114997

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0004080

1 reference

15 October 2017

0 references

1 reference

15 October 2017

PubMed publication ID

19114997

1 reference