Physiological and pathological aspects of Abeta in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron-chelators (Q30855088)

16 November 2017

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Physiological and pathological aspects of Abeta in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron-chelators (English)

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16 November 2017

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Orly Weinreb

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Moussa B H Youdim

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16 November 2017

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16 November 2017

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16 November 2017

Orit Bar-Am

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16 November 2017

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Drug Discovery Targeted to the Alzheimer's APP mRNA 5'-Untranslated Region: The Action of Paroxetine and Dimercaptopropanol

21 June 2018

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The metallobiology of Alzheimer's disease

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Abeta as a bioflocculant: implications for the amyloid hypothesis of Alzheimer's disease.

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A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 June 2018

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Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development

21 June 2018

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Chemistry and biochemistry of oxidative stress in neurodegenerative disease

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains

21 June 2018

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Three histidine residues of amyloid-beta peptide control the redox activity of copper and iron

21 June 2018

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Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice.

25 November 2018

1 reference

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Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5' untranslated region

25 November 2018

1 reference

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Green tea polyphenol (-)-epigallocatechin-3-gallate induces neurorescue of long-term serum-deprived PC12 cells and promotes neurite outgrowth

25 November 2018

1 reference

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Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604902

Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of Abeta42 in a manner which may have consequences for metal chelation therapy in Alzheimer's disease.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604902

Evaluation of HFE (hemochromatosis) mutations as genetic modifiers in sporadic AD and MCI.

25 November 2018

1 reference

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Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604902

Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease.

25 November 2018

1 reference

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Oxidative stress increases expression and activity of BACE in NT2 neurons

25 November 2018

1 reference

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Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region.

25 November 2018

1 reference

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An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

25 November 2018

1 reference

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Oxidative damage is the earliest event in Alzheimer disease

25 November 2018

1 reference

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Effects of pH and metal ions on antioxidative activities of catechins

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604902

In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604902

Alterations in the interaction between iron regulatory proteins and their iron responsive element in normal and Alzheimer's diseased brains.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604902

Activation of NADPH oxidase in Alzheimer's disease brains.

25 November 2018

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Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604902

Oxidative stress induces increase in intracellular amyloid beta-protein production and selective activation of betaI and betaII PKCs in NT2 cells

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604902

Melanotransferrin is produced by senile plaque-associated reactive microglia in Alzheimer's disease.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604902

Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604902

Hypoglycemia enhances the expression of mRNA encoding β-amyloid precursor protein in rat primary cortical astroglial cells

25 November 2018

1 reference

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Mitotic signaling by beta-amyloid causes neuronal death

25 November 2018

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Are hereditary hemochromatosis mutations involved in Alzheimer disease?

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12 December 2020

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12 December 2020

Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes

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12 December 2020

MR evaluation of age-related increase of brain iron in young adult and older normal males

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12 December 2020

Processing of Alzheimer's amyloid precursor protein during H2O2-induced apoptosis in human neuronal cells

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12 December 2020

The amyloid paradox: amyloid-beta-metal complexes can be neurotoxic and neuroprotective

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12 December 2020

The 5'-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive element

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12 December 2020

10.1186/1471-2202-9-S2-S2

Identifiers

DOI

1 reference

Dimensions Publication ID

16 November 2017

0 references

1 reference

16 November 2017

PubMed publication ID

19090990

1 reference