The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions (Q30541820)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23775089%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

review article

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title

The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions (English)

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3 March 2020

1

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3 March 2020

Michel Chrétien

series ordinal

3

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3 March 2020

Majambu Mbikay

series ordinal

4

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3 March 2020

author name string

Mohamad S Sadr

series ordinal

2

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3 March 2020

language of work or name

English

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publication date

17 June 2013

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Journal of Biological Chemistry

3 March 2020

number of pages

9

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based on heuristic

inferred from page(s)

published in

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3 March 2020

volume

288

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3 March 2020

issue

30

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3 March 2020

page(s)

21473-21481

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Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1)

3 March 2020

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SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion

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Low density lipoprotein binds to proprotein convertase subtilisin/kexin type-9 (PCSK9) in human plasma and inhibits PCSK9-mediated low density lipoprotein receptor degradation

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Loss- and gain-of-function PCSK9 variants: cleavage specificity, dominant negative effects, and low density lipoprotein receptor (LDLR) degradation

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SKI-1/S1P inhibition: a promising surrogate to statins to block hepatitis C virus replication

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Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity

20 June 2018

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Evaluation of the anti-arenaviral activity of the subtilisin kexin isozyme-1/site-1 protease inhibitor PF-429242.

20 June 2018

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The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities.

20 June 2018

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The proprotein convertases, 20 years later

20 June 2018

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The Prohormone Theory and the Proprotein Convertases: It Is All About Serendipity

20 June 2018

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On the discovery of precursor processing

20 June 2018

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A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism

20 June 2018

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Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.

20 June 2018

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Proteolytic Processing of Angiopoietin-like Protein 4 by Proprotein Convertases Modulates Its Inhibitory Effects on Lipoprotein Lipase Activity

20 June 2018

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Surface expression of precursor N-cadherin promotes tumor cell invasion

20 June 2018

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In vivo evidence that furin from hepatocytes inactivates PCSK9

20 June 2018

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Effects of the prosegment and pH on the activity of PCSK9: evidence for additional processing events

20 June 2018

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O-glycosylation modulates proprotein convertase activation of angiopoietin-like protein 3: possible role of polypeptide GalNAc-transferase-2 in regulation of concentrations of plasma lipids

20 June 2018

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20 June 2018

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Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis

20 June 2018

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20 June 2018

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Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor

20 June 2018

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Proprotein convertase activation of aggrecanases in cartilage in situ.

20 June 2018

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Knock-out mouse models of proprotein convertases: unique functions or redundancy?

20 June 2018

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In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate

20 June 2018

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The activation and physiological functions of the proprotein convertases

20 June 2018

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Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases

20 June 2018

1 reference

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The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2

20 June 2018

1 reference

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Site-1 protease is essential for endochondral bone formation in mice.

20 June 2018

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The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

20 June 2018

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Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia

20 June 2018

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The proprotein convertases are potential targets in the treatment of dyslipidemia

20 June 2018

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The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

20 June 2018

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Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree

20 June 2018

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Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1.

20 June 2018

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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

20 June 2018

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20 June 2018

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Furin at the cutting edge: from protein traffic to embryogenesis and disease

20 June 2018

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20 June 2018

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Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3.

20 June 2018

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Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene

20 June 2018

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The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P.

20 June 2018

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20 June 2018

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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

20 June 2018

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SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

20 June 2018

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Secreted site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins

20 June 2018

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Proteolytic processing in the secretory pathway

20 June 2018

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The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease

20 June 2018

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Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization

20 June 2018

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The proprotein convertases

20 June 2018

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Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.

20 June 2018

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Role of prohormone convertases in the tissue-specific processing of proglucagon

20 June 2018

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cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases

20 June 2018

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20 June 2018

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Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin

20 June 2018

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The neuroendocrine polypeptide 7B2 is an endogenous inhibitor of prohormone convertase PC2

20 June 2018

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Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones

20 June 2018

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PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues

20 June 2018

1 reference

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A member of the eukaryotic subtilisin family (PC3) has the enzymic properties of the type 1 proinsulin-converting endopeptidase

20 June 2018

1 reference

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Identification of the type 2 proinsulin processing endopeptidase as PC2, a member of the eukaryote subtilisin family.

20 June 2018

1 reference

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Beyond LDL-C lowering: distinct molecular sphingolipids are good indicators of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency

20 June 2018

1 reference

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Transintestinal cholesterol excretion is an active metabolic process modulated by PCSK9 and statin involving ABCB1.

26 November 2018

1 reference

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Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin.

26 November 2018

1 reference

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The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724608

SKI-1 and Furin generate multiple RGMa fragments that regulate axonal growth.

26 November 2018

1 reference

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Gene Inactivation of Proprotein Convertase Subtilisin/Kexin Type 9 Reduces Atherosclerosis in Mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724608

Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724608

Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724608

Disrupted recycling of the low density lipoprotein receptor by PCSK9 is not mediated by residues of the cytoplasmic domain

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724608

Genetic deficiency for proprotein convertase subtilisin/kexin type 2 in mice is associated with decreased adiposity and protection from dietary fat-induced body weight gain

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724608

PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724608

Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724608

The proprotein convertase SKI-1/S1P: alternate translation and subcellular localization

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724608

A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724608

Strain-dependent influences on the hypothalamo-pituitary-adrenal axis profoundly affect the 7B2 and PC2 null phenotypes.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724608

Limited redundancy of the proprotein convertase furin in mouse liver

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724608

Structure of the neural (N-) cadherin prodomain reveals a cadherin extracellular domain-like fold without adhesive characteristics

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724608

Obesity and diabetes in transgenic mice expressing proSAAS.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724608

Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724608

Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724608

Incomplete Processing of Proinsulin to Insulin Accompanied by Elevation of Des-31,32 Proinsulin Intermediates in Islets of Mice Lacking Active PC2

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724608

The C-terminal Region of proSAAS Is a Potent Inhibitor of Prohormone Convertase 1

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724608

Pan-neuronal mRNA expression of the secretory polypeptide 7B2

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23775089

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.R113.481549

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23775089%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23775089%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

PubMed publication ID

23775089

1 reference