Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease (Q30535298)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23184605%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

title

Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease (English)

1 reference

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18 February 2020

1 reference

Nambirajan Govindarajan

1

1 reference

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18 February 2020

Pooja Rao

2

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18 February 2020

Frank Bradke

6

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18 February 2020

Jianrong Lu

7

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18 February 2020

author name string

Susanne Burkhardt

3

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18 February 2020

Farahnaz Sananbenesi

4

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18 February 2020

Oliver M Schlüter

5

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18 February 2020

André Fischer

8

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18 February 2020

publication date

26 November 2012

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18 February 2020

published in

EMBO Molecular Medicine

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18 February 2020

volume

5

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18 February 2020

issue

1

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18 February 2020

page(s)

52-63

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Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease

18 February 2020

cites work

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Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression

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HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation

20 June 2018

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Targeting the correct HDAC(s) to treat cognitive disorders

20 June 2018

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Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer disease

20 June 2018

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Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

20 June 2018

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HDAC6 regulates mitochondrial transport in hippocampal neurons

20 June 2018

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Altered histone acetylation is associated with age-dependent memory impairment in mice.

20 June 2018

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Amyloid-beta-derived diffusible ligands cause impaired axonal transport of mitochondria in neurons

20 June 2018

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Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6

20 June 2018

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Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease

20 June 2018

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HDAC6 is a target for protection and regeneration following injury in the nervous system

20 June 2018

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The epigenetic bottleneck of neurodegenerative and psychiatric diseases

20 June 2018

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Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

20 June 2018

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HDAC2 negatively regulates memory formation and synaptic plasticity.

20 June 2018

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Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin

20 June 2018

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GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons

20 June 2018

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Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

20 June 2018

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Histone deacetylase 6 interacts with the microtubule-associated protein tau

20 June 2018

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Tau-based treatment strategies in neurodegenerative diseases

20 June 2018

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

20 June 2018

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HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions

20 June 2018

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Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders.

20 June 2018

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Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally

20 June 2018

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SIRT2, tubulin deacetylation, and oligodendroglia differentiation.

20 June 2018

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HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

20 June 2018

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Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

20 June 2018

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Microtubule-stabilizing agent prevents protein accumulation-induced loss of synaptic markers

20 June 2018

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20 June 2018

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20 June 2018

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Activity-dependent synapse modulation and the pathogenesis of Alzheimer disease

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets

20 June 2018

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HDAC6 is a microtubule-associated deacetylase

20 June 2018

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Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles

20 June 2018

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Reduction of acetylated alpha-tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in Alzheimer's disease

20 June 2018

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20 June 2018

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HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

21 January 2018

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Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease.

21 January 2018

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21 January 2018

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Abeta promotes Alzheimer's disease-like cytoskeleton abnormalities with consequences to APP processing in neurons

21 January 2018

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The anaphase promoting complex is required for memory function in mice

21 January 2018

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Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

21 January 2018

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Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model

21 January 2018

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Acute impairment of mitochondrial trafficking by beta-amyloid peptides in hippocampal neurons.

21 January 2018

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Akt inhibits MLK3/JNK3 signaling by inactivating Rac1: a protective mechanism against ischemic brain injury

21 January 2018

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Identifiers

DOI

10.1002/EMMM.201201923

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23184605%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23184605%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

PubMed publication ID

23184605

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23184605%20AND%20SRC:MED&resulttype=core&format=json