Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes (Q30466591)

11 August 2017

1 reference

title

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes (English)

1 reference

11 August 2017

Uwe Rudolph

1

1 reference

11 August 2017

Frédéric Knoflach

series ordinal

2

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11 August 2017

language of work or name

English

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21799515

8 December 2024

publication date

29 July 2011

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full work available at URL

11 August 2017

https://europepmc.org/articles/pmc3375401?pdf=render

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8 December 2024

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8 December 2024

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https://doi.org/10.1038/nrd3502

8 December 2024

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21799515

http://www.nature.com/articles/nrd3502.pdf

8 December 2024

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Portable Document Format

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8 December 2024

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Nature Reviews Drug Discovery

8 December 2024

published in

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11 August 2017

10

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11 August 2017

9

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11 August 2017

685-697

1 reference

A novel α5GABA(A)R-positive allosteric modulator reverses hyperactivation of the dopamine system in the MAM model of schizophrenia

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1 reference

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1 reference

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1 reference

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20 June 2018

1 reference

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HZ166, a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain

20 June 2018

1 reference

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Antidepressant-like properties of α2-containing GABAA receptors

20 June 2018

1 reference

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20 June 2018

1 reference

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The role of GABA(A) receptor subtypes as analgesic targets

20 June 2018

1 reference

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gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression

20 June 2018

1 reference

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Mutations in GABAA receptor subunits associated with genetic epilepsies

20 June 2018

1 reference

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Neural bases for addictive properties of benzodiazepines.

20 June 2018

1 reference

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A multicenter, placebo-controlled, double-blind, randomized study of efficacy and safety of ocinaplon (DOV 273,547) in generalized anxiety disorder

20 June 2018

1 reference

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Reducing abuse liability of GABAA/benzodiazepine ligands via selective partial agonist efficacy at alpha1 and alpha2/3 subtypes

20 June 2018

1 reference

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Preclinical and clinical pharmacology of the GABAA receptor alpha5 subtype-selective inverse agonist alpha5IA.

20 June 2018

1 reference

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Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype

20 June 2018

1 reference

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GABAA receptor alpha5 subunits contribute to GABAA,slow synaptic inhibition in mouse hippocampus.

20 June 2018

1 reference

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RO4938581, a novel cognitive enhancer acting at GABAA alpha5 subunit-containing receptors

20 June 2018

1 reference

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Subunit-selective modulation of GABA type A receptor neurotransmission and cognition in schizophrenia

20 June 2018

1 reference

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NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy

20 June 2018

1 reference

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Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflamm

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update

20 June 2018

1 reference

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GABA A receptors: subtypes provide diversity of function and pharmacology

20 June 2018

1 reference

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20 June 2018

1 reference

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GABA(B) receptors: synaptic functions and mechanisms of diversity

20 June 2018

1 reference

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20 June 2018

1 reference

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Regulation of firing of dopaminergic neurons and control of goal-directed behaviors

20 June 2018

1 reference

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The role of GABA in the mediation and perception of pain

20 June 2018

1 reference

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The mechanistic classification of addictive drugs

20 June 2018

1 reference

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L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors.

20 June 2018

1 reference

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GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol

20 June 2018

1 reference

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Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions

20 June 2018

1 reference

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Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons.

20 June 2018

1 reference

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Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample

20 June 2018

1 reference

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New approaches to antidepressant drug discovery: beyond monoamines

20 June 2018

1 reference

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A schizophrenia-related sensorimotor deficit links alpha 3-containing GABAA receptors to a dopamine hyperfunction

20 June 2018

1 reference

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TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.

20 June 2018

1 reference

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Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia

20 June 2018

1 reference

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Construct Validity of the Animal Latent Inhibition Model of Selective Attention Deficits in Schizophrenia

20 June 2018

1 reference

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Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator.

20 June 2018

1 reference

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GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon.

20 June 2018

1 reference

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Cortical inhibitory neurons and schizophrenia

20 June 2018

1 reference

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Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates

20 June 2018

1 reference

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Molecular and neuronal substrates for general anaesthetics

20 June 2018

1 reference

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Analysis of the presence and abundance of GABAA receptors containing two different types of alpha subunits in murine brain using point-mutated alpha subunits

20 June 2018

1 reference

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Positioning of the alpha-subunit isoforms confers a functional signature to gamma-aminobutyric acid type A receptors.

20 June 2018

1 reference

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Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations

20 June 2018

1 reference

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Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors

20 June 2018

1 reference

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Cognitive and sedative effects of benzodiazepine use.

20 June 2018

1 reference

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A new benzodiazepine pharmacology.

20 June 2018

1 reference

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Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtype

20 June 2018

1 reference

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Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor

20 June 2018

1 reference

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Molecular targets for the myorelaxant action of diazepam.

20 June 2018

1 reference

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GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain.

20 June 2018

1 reference

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Mechanism of action of the hypnotic zolpidem in vivo

20 June 2018

1 reference

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Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

20 June 2018

1 reference

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The 'ABC' of GABA receptors

20 June 2018

1 reference

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Modulation of Long-term Potentiation in CA1 Region of Mouse Hippocampal Brain Slices by GABAA Receptor Benzodiazepine Site Ligands

20 June 2018

1 reference

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Antipsychotic effects of bretazenil, a partial benzodiazepine agonist in acute schizophrenia--a study group report.

20 June 2018

1 reference

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Benzodiazepines on trial: a research strategy for their rehabilitation

20 June 2018

1 reference

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Benzodiazepines as antidepressants: does GABA play a role in depression?

20 June 2018

1 reference

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GABAA-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits

20 June 2018

1 reference

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Effects of benzodiazepine microinjection into the amygdala or periaqueductal gray on the expression of conditioned fear and hypoalgesia in rats

20 June 2018

1 reference

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Severe anxiety induced by FG 7142, a beta-carboline ligand for benzodiazepine receptors

20 June 2018

1 reference

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Co-localization of GABA receptors and benzodiazepine receptors in the brain shown by monoclonal antibodies

20 June 2018

1 reference

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Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology.

20 June 2018

1 reference

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Diazepam impairs place learning in the Morris water maze

20 June 2018

1 reference

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Relationship between benzodiazepine receptor occupancy and functional effects in vivo of four ligands of differing intrinsic efficacies

20 June 2018

1 reference

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Benzodiazepine receptor: demonstration in the central nervous system

20 June 2018

1 reference

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Benzodiazepine receptors in rat brain

20 June 2018

1 reference

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A question of balance--positive versus negative allosteric modulation of GABA(A) receptor subtypes as a driver of analgesic efficacy in rat models of inflammatory and neuropathic pain.

20 June 2018

1 reference

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A reduction in hippocampal GABAA receptor alpha5 subunits disrupts the memory for location of objects in mice.

26 November 2018

1 reference

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Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective partial agonist.

26 November 2018

1 reference

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MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans.

26 November 2018

1 reference

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In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.

26 November 2018

1 reference

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GABAergic analgesia: new insights from mutant mice and subtype-selective agonists

26 November 2018

1 reference

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Long-lasting modulation of glutamatergic transmission in VTA dopamine neurons after a single dose of benzodiazepine agonists

26 November 2018

1 reference

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Reversal of pathological pain through specific spinal GABAA receptor subtypes.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Blockade of alcohol's amnestic activity in humans by an alpha5 subtype benzodiazepine receptor inverse agonist

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Association between GABRA1 and drinking behaviors in the collaborative study on the genetics of alcoholism sample.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Isoflurane-induced surgical tolerance mediated only in part by beta3-containing GABA(A) receptors

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Rodent pharmacokinetics and receptor occupancy of the GABAA receptor subtype selective benzodiazepine site ligand L-838417.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

GABA receptors containing the alpha5 subunit mediate the trace effect in aversive and appetitive conditioning and extinction of conditioned fear

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Requirement of alpha5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Allelic and haplotypic association of GABRA2 with alcohol dependence

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Hippocampal alpha5 subunit-containing GABAA receptors modulate the expression of prepulse inhibition

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Specific GABAA circuits for visual cortical plasticity.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Dynamic GABA(A) receptor subtype-specific modulation of the synchrony and duration of thalamic oscillations.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Linkage and linkage disequilibrium mapping of ERP and EEG phenotypes

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Assessment of benzodiazepine dependence in alcohol and drug dependent outpatients: a research report

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Molecular and neuronal substrate for the selective attenuation of anxiety.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

GABAA-receptor alpha-subunit is an essential prerequisite for receptor formation in vivo.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Interaction of Convulsive Ligands with Benzodiazepine Receptors

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375401

Benzodiazepine prescribing to the Swiss adult population: results from a national survey of community pharmacies

26 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNRD3502

Reversal of ketamine-induced working memory impairments by the GABAAalpha2/3 agonist TPA023.

31 March 2020

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNRD3502

GABA(A) receptor subtypes: dissecting their pharmacological functions

31 March 2020

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNRD3502

Efficacy of alprazolam in reducing fluoxetine-induced jitteriness in patients with major depression

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21799515

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Journal of Pharmacology and Experimental Therapeutics

29

261

1113

M Facklam

1992

1 reference

https://api.crossref.org/works/10.1038/NRD3502

8 December 2024

Identifiers

DOI

10.1038/NRD3502

1 reference

Dimensions Publication ID

11 August 2017

0 references

1 reference

11 August 2017

1 reference