Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. (Q30427325)

10 August 2017

Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. (English)

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10 August 2017

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11

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Wladek Minor

15

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author name string

Julie S Barber-Rotenberg

1

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10 August 2017

Saravana P Selvanathan

2

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10 August 2017

Yali Kong

3

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10 August 2017

Hayriye V Erkizan

4

1 reference

10 August 2017

Tara M Snyder

5

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10 August 2017

S Peter Hong

6

1 reference

10 August 2017

Christina L Kobs

7

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10 August 2017

Natalie L South

8

1 reference

10 August 2017

Steven Summer

9

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10 August 2017

Philip J Monroe

10

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10 August 2017

Veselin Dobrev

12

1 reference

10 August 2017

Perrer N Tosso

13

1 reference

10 August 2017

Lauren J Scher

14

1 reference

10 August 2017

Milton L Brown

16

1 reference

10 August 2017

Steven J Metallo

17

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10 August 2017

Aykut Üren

18

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10 August 2017

Jeffrey A Toretsky

19

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10 August 2017

language of work or name

English

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publication date

1 February 2012

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10 August 2017

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10 August 2017

3

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10 August 2017

2

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10 August 2017

172-182

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describes a project that uses

10 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3326647/fullTextXML

inferred from PubMed Central ID database lookup

cites work

YK-4-279 Inhibits ERG and ETV1 Mediated Prostate Cancer Cell Invasion

1 reference

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Oncogenic partnerships: EWS-FLI1 protein interactions initiate key pathways of Ewing's sarcoma

20 June 2018

1 reference

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A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma

20 June 2018

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Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer

20 June 2018

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20 June 2018

A short history of SHELX

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The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics

20 June 2018

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Frequency of the TMPRSS2:ERG gene fusion is increased in moderate to poorly differentiated prostate cancers

20 June 2018

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Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteins

20 June 2018

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HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes

20 June 2018

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Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A.

20 June 2018

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Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.

20 June 2018

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Recombinant EWS-FLI1 oncoprotein activates transcription

20 June 2018

1 reference

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EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.

20 June 2018

1 reference

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Trends in the development of chiral drugs

20 June 2018

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Transcription factors as targets for cancer therapy

20 June 2018

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Intrinsic disorder and protein function

20 June 2018

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Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

20 June 2018

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Clinical pharmacology of thalidomide.

20 June 2018

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Endonuclease G is an apoptotic DNase when released from mitochondria

20 June 2018

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Intrinsically disordered protein

20 June 2018

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Caspase-dependent and -independent death pathways in cancer therapy

20 June 2018

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Molecular genetics of chromosome translocations involving EWS and related family members

20 June 2018

1 reference

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Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

20 June 2018

1 reference

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Molecular characterization of mitochondrial apoptosis-inducing factor

20 June 2018

1 reference

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A new member of the ETS family fused to EWS in Ewing tumors

20 June 2018

1 reference

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Importance of stereospecific bioanalytical monitoring in drug development

20 June 2018

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A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1

20 June 2018

1 reference

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Improved methods for building protein models in electron density maps and the location of errors in these models

20 June 2018

1 reference

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Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

20 June 2018

1 reference

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Multiple independent binding sites for small-molecule inhibitors on the oncoprotein c-Myc.

20 June 2018

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Structural rationale for the coupled binding and unfolding of the c-Myc oncoprotein by small molecules

26 November 2018

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TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort.

26 November 2018

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Expression of TMPRSS2:ERG gene fusion in prostate cancer cells is an important prognostic factor for cancer progression.

26 November 2018

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Local flexibility in molecular function paradigm

26 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22383402

12 December 2020

inferred from PubMed ID database lookup

Processing of X-ray diffraction data collected in oscillation mode

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22383402

12 December 2020

inferred from PubMed ID database lookup

Fusion of an ETS-family gene, EIAF, to EWS by t(17;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22383402

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.18632/ONCOTARGET.454

0 references

1 reference

10 August 2017

PubMed publication ID

22383402

1 reference