Novel insights into protein misfolding diseases revealed by ion mobility-mass spectrometry (Q30426229)

21 June 2017

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title

Novel insights into protein misfolding diseases revealed by ion mobility-mass spectrometry (English)

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21 June 2017

2

Tara L Pukala

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21 June 2017

Danielle M Williams

1

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21 June 2017

publication date

23 January 2013

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Mass Spectrometry Reviews

21 June 2017

published in

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volume

32

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21 June 2017

issue

3

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21 June 2017

page(s)

169-187

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Cellular polyamines promote the aggregation of alpha-synuclein

21 June 2017

cites work

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Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease

21 January 2018

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Amyloid beta-protein monomer structure: a computational and experimental study.

21 January 2018

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Advances in the mass spectrometry of membrane proteins: from individual proteins to intact complexes

21 January 2018

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Structure of the 21-30 fragment of amyloid beta-protein.

21 January 2018

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Protein complexes in the gas phase: technology for structural genomics and proteomics

21 January 2018

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Alpha-synuclein: stable compact and extended monomeric structures and pH dependence of dimer formation

21 January 2018

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Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform.

21 January 2018

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Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

21 January 2018

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Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

21 January 2018

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Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways

21 January 2018

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A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization

21 January 2018

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Biomolecule analysis by ion mobility spectrometry

21 January 2018

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Separation of beta2-microglobulin conformers by high-field asymmetric waveform ion mobility spectrometry (FAIMS) coupled to electrospray ionisation mass spectrometry.

21 January 2018

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Forecasting the global burden of Alzheimer’s disease

21 January 2018

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Collision cross sections of proteins and their complexes: a calibration framework and database for gas-phase structural biology

21 January 2018

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Practical implications of some recent studies in electrospray ionization fundamentals

21 January 2018

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Mass spectrometric analysis of DNA mixtures: instrumental effects responsible for decreased sensitivity with increasing mass

21 January 2018

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Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

21 January 2018

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Protein misfolding, functional amyloid, and human disease

21 January 2018

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Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

21 January 2018

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Naked Protein Conformations: Cytochrome c in the Gas Phase

21 January 2018

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Determination of the oligomer size of amyloidogenic protein beta-amyloid(1-40) by single-molecule spectroscopy

21 January 2018

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Molecular Beams of Macroions

21 January 2018

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Mass spectrometry and protein analysis

21 January 2018

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Monitoring the earliest amyloid-beta oligomers via quantized photobleaching of dye-labeled peptides

21 January 2018

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Human islet amyloid polypeptide monomers form ordered beta-hairpins: a possible direct amyloidogenic precursor

21 January 2018

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The amyloid formation mechanism in human IAPP: dimers have β-strand monomer-monomer interfaces

21 January 2018

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Unraveling the mysteries of protein folding and misfolding

21 January 2018

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Defining the mechanism of polymerization in the serpinopathies

21 January 2018

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Electrospray ionization for mass spectrometry of large biomolecules

21 January 2018

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Aβ(39-42) modulates Aβ oligomerization but not fibril formation

21 January 2018

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Applications of a travelling wave-based radio-frequency-only stacked ring ion guide

21 January 2018

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Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease

21 January 2018

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Spermine binding to Parkinson's protein alpha-synuclein and its disease-related A30P and A53T mutants

21 January 2018

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Conformational stability of Syrian hamster prion protein PrP(90-231).

21 January 2018

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Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease

21 January 2018

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The energy landscape of unsolvated peptides: the role of context in the stability of alanine/glycine helices

21 January 2018

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Structural analysis of prion proteins by means of drift cell and traveling wave ion mobility mass spectrometry

21 January 2018

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Three-dimensional ion mobility/TOFMS analysis of electrosprayed biomolecules

21 January 2018

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Methionine 35 oxidation reduces fibril assembly of the amyloid abeta-(1-42) peptide of Alzheimer's disease

21 January 2018

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Conformations of Gly(n)H+ and Ala(n)H+ peptides in the gas phase

21 January 2018

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Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes

21 January 2018

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Gas-phase unfolding and disassembly reveals stability differences in ligand-bound multiprotein complexes

21 January 2018

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The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

21 January 2018

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Transthyretin mutations in health and disease.

21 January 2018

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Sizing large proteins and protein complexes by electrospray ionization mass spectrometry and ion mobility

21 January 2018

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Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons

21 January 2018

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Abeta40 inhibits amyloid deposition in vivo.

21 January 2018

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Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease

21 January 2018

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Protein folding and interactions revealed by mass spectrometry.

21 January 2018

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Methodology for measuring conformation of solvent-disrupted protein subunits using T-WAVE ion mobility MS: an investigation into eukaryotic initiation factors

21 January 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

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The relationship of Parkinson disease with aging

21 January 2018

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GroEL stimulates protein folding through forced unfolding

21 January 2018

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Studying noncovalent protein complexes by electrospray ionization mass spectrometry

21 January 2018

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Electrospray ionization mass spectrometry and ion mobility analysis of the 20S proteasome complex

21 January 2018

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Amyloid beta protein: Abeta40 inhibits Abeta42 oligomerization

21 January 2018

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Preparing protein microarrays by soft-landing of mass-selected ions

21 January 2018

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Integrating ion mobility mass spectrometry with molecular modelling to determine the architecture of multiprotein complexes

21 January 2018

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Evolutionary changes to transthyretin: structure-function relationships

21 January 2018

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21 January 2018

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Further purification and characterization of scrapie prions

21 January 2018

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Subunit architecture of multiprotein assemblies determined using restraints from gas-phase measurements

21 January 2018

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Unravelling the twists and turns of the serpinopathies.

21 January 2018

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Evidence for macromolecular protein rings in the absence of bulk water.

21 January 2018

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Travelling wave ion mobility mass spectrometry studies of protein structure: biological significance and comparison with X-ray crystallography and nuclear magnetic resonance spectroscopy measurements.

21 January 2018

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The role of mass spectrometry in structure elucidation of dynamic protein complexes

21 January 2018

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Fundamentals of traveling wave ion mobility spectrometry

21 January 2018

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Monitoring copopulated conformational states during protein folding events using electrospray ionization-ion mobility spectrometry-mass spectrometry

21 January 2018

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Elongated oligomers in beta2-microglobulin amyloid assembly revealed by ion mobility spectrometry-mass spectrometry

21 January 2018

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Probing genuine strong interactions and post-translational modifications in the heterogeneous yeast exosome protein complex.

21 January 2018

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Electrosonic spray ionization. A gentle technique for generating folded proteins and protein complexes in the gas phase and for studying ion-molecule reactions at atmospheric pressure

21 January 2018

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Protein and polymer analyses up tom/z 100 000 by laser ionization time-of-flight mass spectrometry

21 January 2018

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Characterization of phosphorylated peptides using traveling wave-based and drift cell ion mobility mass spectrometry

21 January 2018

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Stability and shape of hepatitis B virus capsids in vacuo

21 January 2018

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Ion mobility mass spectrometry of proteins and protein assemblies.

21 January 2018

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Evidence for a partially folded intermediate in alpha-synuclein fibril formation

21 January 2018

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Tandem mass spectrometry of intact GroEL-substrate complexes reveals substrate-specific conformational changes in the trans ring.

21 January 2018

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Chaperonin complexes monitored by ion mobility mass spectrometry

21 January 2018

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Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry

21 January 2018

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

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Protein aggregation--pathways and influencing factors

21 January 2018

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Molecular mechanisms of alpha-synuclein neurodegeneration

21 January 2018

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Analytical properties of the nanoelectrospray ion source

21 January 2018

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Ligand binding to distinct states diverts aggregation of an amyloid-forming protein

21 January 2018

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The effect of calcium ions and peptide ligands on the relative stabilities of the calmodulin dumbbell and compact structures

21 January 2018

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Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization

21 January 2018

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Structural characterization of a soluble amyloid beta-peptide oligomer.

21 January 2018

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APP processing in Alzheimer's disease

21 January 2018

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Z-Phe-Ala-diazomethylketone (PADK) disrupts and remodels early oligomer states of the Alzheimer disease Aβ42 protein.

21 January 2018

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Gas-phase metalloprotein complexes interrogated by ion mobility-mass spectrometry

21 January 2018

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The protofilament substructure of amyloid fibrils11Edited by F. E. Cohen

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MAS.21358

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21 June 2017

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