A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis. (Q30408967)

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1 March 2020

title

A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis (English)

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4

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Brett W Stringer

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Anthony S. Don

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author name string

Hazem J Abuhusain

1

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Azadeh Matin

2

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Qiao Qiao

3

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Nupur Kain

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Bryan W Day

6

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Benjamin Daniels

8

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Maarit A Laaksonen

9

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Charlie Teo

10

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Kerrie L McDonald

11

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language of work or name

English

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publication date

21 November 2013

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Journal of Biological Chemistry

1 March 2020

published in

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volume

288

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issue

52

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page(s)

37355-37364

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describes a project that uses

1 March 2020

ImageQuant

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11 June 2022

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based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.

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Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate

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Sphingosine Kinase-1 Enhances Resistance to Apoptosis through Activation of PI3K/Akt/NF-κB Pathway in Human Non–Small Cell Lung Cancer

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Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro.

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Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways

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Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts

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Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

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Sphingosine-1-phosphate regulates glioblastoma cell invasiveness through the urokinase plasminogen activator system and CCN1/Cyr61

20 June 2018

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Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival

20 June 2018

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Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate

20 June 2018

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Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.

20 June 2018

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20 June 2018

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20 June 2018

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Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages

20 June 2018

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Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation

20 June 2018

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20 June 2018

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Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines

20 June 2018

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20 June 2018

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20 June 2018

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Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference

20 June 2018

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20 June 2018

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20 June 2018

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Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2

20 June 2018

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An oncogenic role of sphingosine kinase

20 June 2018

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Kinase suppressor of Ras is ceramide-activated protein kinase

20 June 2018

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Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

20 June 2018

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Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice

20 June 2018

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20 June 2018

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EphA3 maintains tumorigenicity and is a therapeutic target in glioblastoma multiforme.

20 June 2018

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MMSAT: automated quantification of metabolites in selected reaction monitoring experiments

26 November 2018

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Mass and relative elution time profiling: two-dimensional analysis of sphingolipids in Alzheimer's disease brains.

26 November 2018

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An optimized three-dimensional in vitro model for the analysis of angiogenesis

26 November 2018

1 reference

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Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue

26 November 2018

1 reference

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Lysophospholipids are potential biomarkers of ovarian cancer

26 November 2018

1 reference

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Ceramide levels are inversely associated with malignant progression of human glial tumors.

26 November 2018

1 reference

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Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24265321

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M113.494740

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24265321%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24265321%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

24265321

1 reference