Philosophy of new drug discovery (Q30405223)

22 September 2017

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title

Philosophy of new drug discovery (English)

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22 September 2017

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Omura S

1

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22 September 2017

1 September 1986

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22 September 2017

Microbiological Reviews

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22 September 2017

50

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22 September 2017

3

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22 September 2017

259-279

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[The therapeutic effect of nanaomycin A against experimental Trichophyton mentagrophytes infection in guinea pigs (author's transl)].

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Stimulation of leucomycin production by magnesium phosphate and its relevance to nitrogen catabolite regulation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

A new antitumor antibiotic, stubomycin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Cervinomycin A1 and A2, new antibiotics active against anaerobes, produced by Streptomyces cervinus sp. nov.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

OM-173, new nanaomycin-type antibiotics produced by a strain of Streptomyces. Taxonomy, production, isolation and biological properties

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Cerulenin resistance in a cerulenin-producing fungus. III. Studies on active-site peptides of fatty acid synthetase from Cephalosporium caerulens.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Irumamycin, an antifungal 20-membered macrolide produced by a Streptomyces. Taxonomy, fermentation and biological properties

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Gastrointestinal motor-stimulating activity of macrolide antibiotics and analysis of their side effects on the canine gut

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Ivermectin: a review of efficacy and safety

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Oxetin, a new antimetabolite from an actinomycete. Fermentation, isolation, structure and biological activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Ivermectin in onchocerciasis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Studies on cerulenin, 3. Isolation and physico-chemical properties of cerulenin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Studies on antibiotic O-2867, a new antiobiotic

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

In vitro and in vivo activity of penicillinase inhibitor KA-107 against Staphylococcus aureus FS-1277

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Studies on penicillinase inhibitors produced by microorganisms

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Gastrointestinal motor-stimulating activity of macrolide antibiotics and the structure-activity relationship

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Double-blind study of ivermectin and diethylcarbamazine in African onchocerciasis patients with ocular involvement.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Nanaomycins, new antibiotics produced by a strain of Streptomyces. I. Taxonomy, isolation, characterization and biological properties

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Structure of a new antimicrobial unsaturated fatty acid from Sm. kitasatoenis NU-23-1

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

A new antibiotic,, asukamycin, produced by Streptomyces

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Production of quinoline-2-methanol and quinoline-2-methanol acetate by a new species of Kitasatoa Kitasato griseophaeus

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

A new antitumor antibiotic, PO-357.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

A new antibiotic, setomimycin, produced by a strain of Streptomyces

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Production of deoxyfrenolicin and a new antibiotic, frenolicin B by Streptomyces roseofulvus strain AM-3867.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Aurantinin, a new antibiotic of bacterial origin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

1,3-Diphenethylurea from Streptomyces sp. No. AM-2498

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Cerulenin resistance in a cerulenin-producing fungus. Isolation of cerulenin insensitive fatty acid synthetase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Structure of nanaomycin E, a new nanaomycin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Studies on bacterial cell wall inhibitors. VII. Azureomycins A and B, new antibiotics produced by Pseudonocardia azurea nov. sp. Taxonomy of the producing organism, isolation, characterization and biological properties

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Herquline, a new alkaloid produced by Penicillium herquei. Fermentation, isolation and properties

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Antitumor activity of prumycin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Olivanic acids, a family of beta-lactam antibiotics with beta-lactamase inhibitory properties produced by Streptomyces species. I. Detection, properties and fermentation studies

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Reaction of Yeast Fatty Acid Synthetase with Iodoacetamide. 2. Identification of the Amino Acid Residues Reacting with Iodoacetamide and Primary Structure of a Peptide Containing the Peripheral Sulfhydryl Group

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Binding of Thienamycin and Clavulanic Acid to the Penicillin-Binding Proteins of Escherichia coli K-12

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

2'-Amino-2'-deoxyadenosine produced by a strain of Actinomadura

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Thiotetromycin, a new antibiotic. Taxonomy, production, isolation, and physicochemical and biological properties.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Karabemycin, a new antimetabolite of glutamine produced by a strain of streptomycete

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Antiviral activities of pentalenolactones

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373071

Effect of ammonium ion, inorganic phosphate and amino acids on the biosynthesis of protylonolide, a precursor of tylosin aglycone

26 November 2018

1 reference

12 December 2020

Repression of beta-lactam production in Cephalosporium acremonium by nitrogen sources

1 reference

12 December 2020

Takaokamycin, a new peptide antibiotic produced by Streptomyces sp

1 reference

12 December 2020

Phosalacine, a new herbicidal antibiotic containing phosphinothricin. Fermentation, isolation, biological activity and mechanism of action

1 reference

12 December 2020

The structure of phosalacine, a new herbicidal antibiotic containing phosphinothricin

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12 December 2020

Chemical modification and antitumor activity of herbimycin A. 8,9-Epoxide, 7,9-cyclic carbamate, and 17 or 19-amino derivatives

1 reference

12 December 2020

Production of ‘hybrid’ antibiotics by genetic engineering

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12 December 2020

Adechlorin, a new adenosine deaminase inhibitor containing chlorine production, isolation and properties

1 reference

12 December 2020

Diazaquinomycin A, a new antifolate antibiotic, inhibits thymidylate synthase

1 reference

12 December 2020

Structure activity relationships of spiramycins

1 reference

12 December 2020

Luminamicin, a new antibiotic. Production, isolation and physico-chemical and biological properties

1 reference

12 December 2020

Anticoccidial activity of frenolicin B and its derivatives

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12 December 2020

Anomeric purine nucleosides of the furanose form of amino-2-deoxy-D-ribose

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12 December 2020

Hybrid biosynthesis of derivatives of protylonolide and M-4365 by macrolide-producing microorganisms

1 reference

12 December 2020

The structures of leucomycin A4A5A6A7A8 and A9

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12 December 2020

Inhibition of fatty acid synthetases by the antibiotic cerulenin

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12 December 2020

Revised structure of cerulenin

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12 December 2020

The mechanism of prumycin action

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12 December 2020

Structure of prumycin

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12 December 2020

Isolation and characterization of a new antitumor antibiotic OS-3256-B from Streptomyces candidus var. azaticus

1 reference

12 December 2020

A new peptide antibiotic KM-8

1 reference

12 December 2020

Revised structure for an alkaloid from Streptomyces sp. NA-337

1 reference

12 December 2020

A kaloid from Thermoactinomyces species

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12 December 2020

Naturally-occurring beta-lactamase inhibitors with antibacterial activity

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12 December 2020

New antitumor antibiotics, OS-4742 A1, A2, B1 and B2 produced by a strain of Streptomyces

1 reference

12 December 2020

Studies on bacterial cell wall inhibitors. VI. Screening method for the specific inhibitors of peptidoglycan synthesis

1 reference

12 December 2020

Studies on antitumor activity of prumycin. IV. Effect of prumycin on mouse immune system

1 reference

12 December 2020

A new peptide antibiotic, alboleutin

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12 December 2020

The site of inhibition of bacterial cell wall peptidoglycan synthesis by azureomycin B, a new antibiotic

1 reference

12 December 2020

Setamycin, a new antibiotic

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12 December 2020

A potent prolyl hydroxylase inhibitor, P-1894B, produced by a strain of Streptomyces

1 reference

12 December 2020

1 reference

12 December 2020

Virantmycin, a new antiviral antibiotic produced by a strain of Streptomyces

1 reference

12 December 2020

Acyl derivatives of 16-membered macrolides. I. Synthesis and biological properties of 3"-O-propionylleucomycin A5 (TMS-19-Q)

1 reference

12 December 2020

Irumamycin, a new antibiotic active against phytopathogenic fungi

1 reference

12 December 2020

Biosynthesis of vineomycins A1 and B2

1 reference

12 December 2020

The mode of action of nanaomycins D and A on a gram-negative marine bacterium Vibrio alginolyticus

1 reference

12 December 2020

OM-704 A, a new antibiotic active against gram-positive bacteria produced by Streptomyces sp

1 reference

12 December 2020

Biosynthesis of nanaomycin. III. Nanaomycin A formation from nanaomycin D by nanaomycin D reductase via a hydroquinone

1 reference

12 December 2020

AM-2604 A, a new antiviral antibiotic produced by a strain of Streptomyces

1 reference

12 December 2020

Factumycin, a new antibiotic (A40A): fermentation, isolation and antibacterial spectrum

1 reference

12 December 2020

Biosynthetic origin of carbons 3 and 4 of leucomycin aglycone

1 reference

12 December 2020

Valine as a precursor of n-butyrate unit in the biosynthesis of macrolide aglycone

1 reference

12 December 2020

Hybrid biosynthesis of a new macrolide antibiotic by a daunomycin-producing microorganism

1 reference

12 December 2020

Chimeramycins: new macrolide antibiotics produced by hybrid biosynthesis

1 reference

12 December 2020

New 20-membered lactones, irumanolides I and II, produced by a mutant of Streptomyces

1 reference

12 December 2020

Taxonomic studies of a stubomycin--(hitachimycin)--producing actinomycete

1 reference

12 December 2020

Structure of a new antibacterial antibiotic, thiotetromycin

1 reference

12 December 2020

The structure of virustomycin A

1 reference

12 December 2020

Identifiers

PMC publication ID

373071

1 reference

PMC publication ID

373071

22 September 2017

PubMed publication ID

3534537

1 reference

PMC publication ID

373071