Structural waters define a functional channel mediating activation of the GPCR, rhodopsin. (Q30380117)

19 August 2017

Structural waters define a functional channel mediating activation of the GPCR, rhodopsin. (English)

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G protein-coupled receptor

19 August 2017

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4

Krzysztof Palczewski

1 reference

19 August 2017

3

Beata Jastrzebska

1 reference

19 August 2017

Thomas E Angel

1

1 reference

19 August 2017

Sayan Gupta

series ordinal

2

1 reference

19 August 2017

Mark R Chance

series ordinal

5

1 reference

19 August 2017

language of work or name

English

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publication date

13 August 2009

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19 August 2017

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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19 August 2017

106

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19 August 2017

34

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19 August 2017

14367-14372

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Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors

19 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Crystal structure of opsin in its G-protein-interacting conformation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Synchrotron protein footprinting supports substrate translocation by ClpA via ATP-induced movements of the D2 loop

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Crystal structure of the ligand-free G-protein-coupled receptor opsin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Crystal structure of squid rhodopsin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Vertebrate membrane proteins: structure, function, and insights from biophysical approaches

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

New G-protein-coupled receptor crystal structures: insights and limitations

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Water as an active constituent in cell biology

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Hydroxyl radical-mediated modification of proteins as probes for structural proteomics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

The Beamline X28C of the Center for Synchrotron Biosciences: a national resource for biomolecular structure and dynamics experiments using synchrotron footprinting.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Visualizing Arp2/3 complex activation mediated by binding of ATP and WASp using structural mass spectrometry

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Crystal structure of a photoactivated deprotonated intermediate of rhodopsin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Local peptide movement in the photoreaction intermediate of rhodopsin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

G protein-coupled receptor rhodopsin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Radiolytic protein footprinting with mass spectrometry to probe the structure of macromolecular complexes.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Crystallographic analysis of primary visual photochemistry

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Location of Trp265 in metarhodopsin II: implications for the activation mechanism of the visual receptor rhodopsin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Secondary reactions and strategies to improve quantitative protein footprinting.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Changes in interhelical hydrogen bonding upon rhodopsin activation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Structure of bovine rhodopsin in a trigonal crystal form.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

TAUTOMERIC FORMS OF METARHODOPSIN.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

The molar extinction of rhodopsin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Ligand channeling within a G-protein-coupled receptor. The entry and exit of retinals in native opsin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Signaling states of rhodopsin. Formation of the storage form, metarhodopsin III, from active metarhodopsin II

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Crystal structure of rhodopsin: A G protein-coupled receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Millisecond radiolytic modification of peptides by synchrotron X-rays identified by mass spectrometry

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Effect of protein hydration on receptor conformation: decreased levels of bound water promote metarhodopsin II formation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Effect of carboxyl mutations on functional properties of bovine rhodopsin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0901074106

The light reaction in the bleaching of rhodopsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0901074106

Effect of ethanol and osmotic stress on receptor conformation. Reduced water activity amplifies the effect of ethanol on metarhodopsin II formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0901074106

[22] Time-resolved synchrotron X-ray footprinting and its application to RNA folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0901074106

RNA Folding at Millisecond Intervals by Synchrotron Hydroxyl Radical Footprinting

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0901074106

Installation and testing of a focusing mirror at beamline X28C for high flux x-ray radiolysis of biological macromolecules

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732891

Functional waters in intraprotein proton transfer monitored by FTIR difference spectroscopy

26 November 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0901074106

Sulfhydryl chemistry of rhodopsin

21 January 2018

1 reference

12 December 2020

35 Preparation of antibodies to rhodopsin and the large protein of rod outer segments

1 reference

12 December 2020

Light-dependent transducin activation by an ultraviolet-absorbing rhodopsin mutant

1 reference

12 December 2020

Rhodopsin activation: effects on the metarhodopsin I-metarhodopsin II equilibrium of neutralization or introduction of charged amino acids within putative transmembrane segments

1 reference

12 December 2020

Structure and function in rhodopsin. Measurement of the rate of metarhodopsin II decay by fluorescence spectroscopy

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0901074106

1 reference

19 August 2017

0 references

1 reference

19 August 2017

PubMed publication ID

19706523

1 reference