Assessing histone demethylase inhibitors in cells: lessons learned. (Q30361704)

15 October 2017

Assessing histone demethylase inhibitors in cells: lessons learned. (English)

1 reference

15 October 2017

1 reference

Christopher J. Schofield

21

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15 October 2017

4

Pavel Savitsky

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Akane Kawamura

Akane Kawamura

23

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Susanne Müller

Susanne Müller

27

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Paul E. Brennan

Paul E Brennan

25

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Gian Filippo Ruda

Gian Filippo Ruda

7

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Florence Raynaud

Florence Raynaud

11

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Chas Bountra

22

Chas Bountra

1 reference

15 October 2017

20

Udo Oppermann

1 reference

15 October 2017

Stephanie B Hatch

1

1 reference

15 October 2017

Clarence Yapp

2

1 reference

15 October 2017

Raquel C Montenegro

3

1 reference

15 October 2017

Pavel Savitsky

4

1 reference

15 October 2017

Vicki Gamble

5

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15 October 2017

Anthony Tumber

6

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15 October 2017

Vassilios Bavetsias

8

1 reference

15 October 2017

Oleg Fedorov

9

1 reference

15 October 2017

Butrus Atrash

10

1 reference

15 October 2017

Rachel Lanigan

12

1 reference

15 October 2017

LeAnne Carmichael

13

1 reference

15 October 2017

Kathy Tomlin

14

1 reference

15 October 2017

Rosemary Burke

15

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15 October 2017

Susan M Westaway

16

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15 October 2017

Jack A Brown

17

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15 October 2017

Rab K Prinjha

18

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15 October 2017

Elisabeth D Martinez

19

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15 October 2017

Julian Blagg

24

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15 October 2017

Olivia Rossanese

26

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15 October 2017

1 March 2017

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15 October 2017

Epigenetics & Chromatin

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15 October 2017

10

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15 October 2017

9

1 reference

Identification of potent, selective KDM5 inhibitors

15 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

BET inhibition as a new strategy for the treatment of gastric cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Structural analysis of human KDM5B guides histone demethylase inhibitor development

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Cell-based assays to support the profiling of small molecules with histone methyltransferase and demethylase modulatory activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Recent Progress in Histone Demethylase Inhibitors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Lateral Thinking: How Histone Modifications Regulate Gene Expression

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Histone demethylases in chromatin biology and beyond

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

The interplay of histone modifications - writers that read

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Advances in the development of histone lysine demethylase inhibitors.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Targeting histone lysine methylation in cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Histone core modifications regulating nucleosome structure and dynamics

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Inhibition of demethylases by GSK-J1/J4.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Epigenetic regulation of memory by acetylation and methylation of chromatin: implications in neurological disorders, aging, and addiction

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

The roles of Jumonji-type oxygenases in human disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Loss of histone H3 methylation at lysine 4 triggers apoptosis in Saccharomyces cerevisiae

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Incorporating DNA shearing in standard affinity purification allows simultaneous identification of both soluble and chromatin-bound interaction partners

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Epigenetic chemical probes.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Bromodomains as therapeutic targets

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Methylation of histone H3 lysine 27 associated with apoptosis in osteosarcoma cells induced by staurosporine

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5333395

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases

3 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2FS13072-017-0116-6

Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2FS13072-017-0116-6

Interrogating the Druggability of the 2-Oxoglutarate-Dependent Dioxygenase Target Class by Chemical Proteomics

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2FS13072-017-0116-6

HDAC inhibitors induce global changes in histone lysine and arginine methylation and alter expression of lysine demethylases

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28265301

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The condensation of chromatin in apoptotic thymocytes shows a specific structural change

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28265301

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/S13072-017-0116-6

1 reference

Dimensions Publication ID

15 October 2017

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/s13072-017-0116-6

1 reference

15 October 2017

PubMed publication ID

28265301

1 reference