Warts Dmel_CG12072 (Q29815953)

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Protein found in Drosophila melanogaster

warts/D-lats
Warts/Lats
large tumor suppressor
warts
CG12072-PA
wts-PA
warts kinase
CG12072 gene product from transcript CG12072-RA
wts
large tumor supressor
miracle-gro
warts/large tumour suppressor

Language	Label	Description	Also known as
English	Warts Dmel_CG12072	Protein found in Drosophila melanogaster	warts/D-lats Warts/Lats large tumor suppressor warts CG12072-PA wts-PA warts kinase CG12072 gene product from transcript CG12072-RA wts large tumor supressor miracle-gro warts/large tumour suppressor

Statements

1 reference

25 May 2022

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VA38

AGC-kinase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

protein kinase activity

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

protein serine/threonine kinase activity

determination method or standard

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

1 January 2018

Protein kinases and phosphatases in the Drosophila genome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

1 January 2018

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

protein binding

determination method or standard

6 references

1 January 2018

Ajuba LIM proteins are negative regulators of the Hippo signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

1 January 2018

Control of cell proliferation and apoptosis by mob as tumor suppressor, mats

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

1 January 2018

Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

1 January 2018

Riquiqui and minibrain are regulators of the hippo pathway downstream of Dachsous

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

1 January 2018

Zyxin links fat signaling to the hippo pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

1 January 2018

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

kinase activity

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

transferase activity

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

metal ion binding

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

microtubule organizing center

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

adherens junction

determination method or standard

1 reference

1 January 2018

Cytoskeletal tension inhibits Hippo signaling through an Ajuba-Warts complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

biological process

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

cell fate specification

determination method or standard

1 reference

1 January 2018

Opposite feedbacks in the Hippo pathway for growth control and neural fate.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

border follicle cell migration

determination method or standard

1 reference

1 January 2018

The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

open tracheal system development

determination method or standard

1 reference

1 January 2018

A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

imaginal disc growth

determination method or standard

1 reference

1 January 2018

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

negative regulation of cell population proliferation

determination method or standard

3 references

1 January 2018

Mechanisms of size control.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

1 January 2018

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

1 January 2018

The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

regulation of cell shape

determination method or standard

1 reference

1 January 2018

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

response to ionizing radiation

determination method or standard

1 reference

1 January 2018

Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

regulation of glucose metabolic process

determination method or standard

1 reference

1 January 2018

Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

phosphorylation

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

peptidyl-serine phosphorylation

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

hippo signaling

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

regulation of cell population proliferation

determination method or standard

1 reference

1 January 2018

Regulation of Cell Cycles in Drosophila Development: Intrinsic and Extrinsic Cues

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

determination method or standard

1 reference

1 January 2018

Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

positive regulation of apoptotic process

determination method or standard

1 reference

1 January 2018

salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

apical protein localization

determination method or standard

1 reference

1 January 2018

The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

R8 cell fate specification

determination method or standard

1 reference

1 January 2018

The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

regulation of imaginal disc growth

determination method or standard

1 reference

1 January 2018

Regulation of Cell Cycles in Drosophila Development: Intrinsic and Extrinsic Cues

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

negative regulation of transcription, DNA-templated

determination method or standard

1 reference

1 January 2018

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

regulation of dendrite morphogenesis

determination method or standard

1 reference

1 January 2018

The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

negative regulation of glial cell proliferation

determination method or standard

1 reference

1 January 2018

Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

stem cell proliferation

determination method or standard

1 reference

1 January 2018

Hippo signaling regulatesDrosophilaintestine stem cell proliferation through multiple pathways

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

negative regulation of canonical Wnt signaling pathway

determination method or standard

1 reference

1 January 2018

The Hippo pathway regulates Wnt/beta-catenin signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

determination method or standard

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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