Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging (Q29614783)

Europe PubMed Central

title

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging (English)

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30 April 2017

0 references

1 reference

Morimoto RI

1

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18519635

30 April 2017

language of work or name

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30 April 2017

publication date

1 June 2008

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30 April 2017

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volume

22

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issue

11

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18519635

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page(s)

1427-38

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18519635

Adapting proteostasis for disease intervention

30 April 2017

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Opposing activities protect against age-onset proteotoxicity

30 April 2017

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30 April 2017

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30 April 2017

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30 April 2017

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30 April 2017

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30 April 2017

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The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

30 April 2017

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Molecular chaperones in the cytosol: from nascent chain to folded protein

30 April 2017

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Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1

30 April 2017

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Impairment of the ubiquitin-proteasome system by protein aggregation

30 April 2017

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30 April 2017

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A yeast prion provides a mechanism for genetic variation and phenotypic diversity

30 April 2017

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A Drosophila model of Parkinson's disease

30 April 2017

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Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

30 April 2017

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Hsp90 as a capacitor for morphological evolution

30 April 2017

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In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis

30 April 2017

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Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

30 April 2017

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Molecular chaperones as HSF1-specific transcriptional repressors

30 April 2017

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daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

30 April 2017

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Repression of human heat shock factor 1 activity at control temperature by phosphorylation

30 April 2017

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A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

30 April 2017

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The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding

30 April 2017

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Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

30 April 2017

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Protein disaggregation mediated by heat-shock protein Hsp104.

30 April 2017

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The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression

30 April 2017

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Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule.

30 April 2017

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Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells

3 June 2018

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The structural basis of yeast prion strain variants

3 June 2018

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Prion recognition elements govern nucleation, strain specificity and species barriers

3 June 2018

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Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity

3 June 2018

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Heat shock factor 1 as a coordinator of stress and developmental pathways

3 June 2018

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Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expression

3 June 2018

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Inhibitors of the HSP90 molecular chaperone: current status

3 June 2018

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Progressive disruption of cellular protein folding in models of polyglutamine diseases.

3 June 2018

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Heat shock response modulators as therapeutic tools for diseases of protein conformation

3 June 2018

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Chaperone-assisted folding of newly synthesized proteins in the cytosol

3 June 2018

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Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB.

3 June 2018

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Celastrols as inducers of the heat shock response and cytoprotection.

3 June 2018

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Inefficient degradation of truncated polyglutamine proteins by the proteasome

3 June 2018

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Altered Hsp90 function in cancer: a unique therapeutic opportunity.

3 June 2018

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Genome-wide analysis of the biology of stress responses through heat shock transcription factor

3 June 2018

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Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation

3 June 2018

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Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones

3 June 2018

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The role of heat shock transcription factor 1 in the genome-wide regulation of the mammalian heat shock response

3 June 2018

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Transcription Factor and Polymerase Recruitment, Modification, and Movement on dhsp70 In Vivo in the Minutes following Heat Shock

3 June 2018

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The Stress Response: Implications for the Clinical Development of Hsp90 Inhibitors

3 June 2018

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Tracking FACT and the RNA polymerase II elongation complex through chromatin in vivo

3 June 2018

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High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1.

3 June 2018

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Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

3 June 2018

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Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract

3 June 2018

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Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins.

3 June 2018

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Brain abnormalities, defective meiotic chromosome synapsis and female subfertility in HSF2 null mice

3 June 2018

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Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death

3 June 2018

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Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock

3 June 2018

1 reference

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Roles of the heat shock transcription factors in regulation of the heat shock response and beyond

3 June 2018

1 reference

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Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth.

3 June 2018

1 reference

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Nucleated conformational conversion and the replication of conformational information by a prion determinant

3 June 2018

1 reference

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Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents.

3 June 2018

1 reference

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Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.

3 June 2018

1 reference

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Glutamine repeats and neurodegeneration

3 June 2018

1 reference

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Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

3 June 2018

1 reference

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P-TEFb kinase recruitment and function at heat shock loci

3 June 2018

1 reference

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Genetic suppression of polyglutamine toxicity in Drosophila

3 June 2018

1 reference

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Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

3 June 2018

1 reference

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Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila

3 June 2018

1 reference

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Heat shock proteins as cellular lifeguards

3 June 2018

1 reference

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Tissue-specific expression of dominant negative mutant Drosophila HSC70 causes developmental defects and lethality

3 June 2018

1 reference

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Glutamine repeats and neurodegenerative diseases: molecular aspects

3 June 2018

1 reference

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Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron

3 June 2018

1 reference

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Protein precipitation: a common etiology in neurodegenerative disorders?

3 June 2018

1 reference

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Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathway

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

3 June 2018

1 reference

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Heat shock transcription factors: structure and regulation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Regulatory differences in the stress response of hippocampal neurons and glial cells after heat shock.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Arachidonate is a potent modulator of human heat shock gene transcription

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Deficient induction of human hsp70 heat shock gene transcription in Y79 retinoblastoma cells despite activation of heat shock factor 1.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Pharmacological modulation of heat shock factor 1 by antiinflammatory drugs results in protection against stress-induced cellular damage

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Mechanism of GroEL action: Productive release of polypeptide from a sequestered position under groes

3 June 2018

1 reference

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Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans

3 June 2018

1 reference

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Heat shock-induced translational control of HSP70 and globin synthesis in chicken reticulocytes

3 June 2018

1 reference

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Developmental control of the heat shock response in Xenopus

3 June 2018

1 reference

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Cellular and biochemical events in mammalian cells during and after recovery from physiological stress

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Posttranscriptional regulation of hsp70 expression in human cells: effects of heat shock, inhibition of protein synthesis, and adenovirus infection on translation and mRNA stability

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Selective induction of a heat shock gene in fibre tracts and cerebellar neurons of the rabbit brain detected by in situ hybridization

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Maximal stress-induced transcription from the human HSP70 promoter requires interactions with the basal promoter elements independent of rotational alignment

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Reduced levels of hsp90 compromise steroid receptor action in vivo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Cooperative binding of Drosophila heat shock factor to arrays of a conserved 5 bp unit.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

The consequences of expressing hsp70 in Drosophila cells at normal temperatures

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Antiproliferative prostaglandins activate heat shock transcription factor

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Protein oxidation and aging

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Dynamics of heat shock factor association with native gene loci in living cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Activation of the heat shock factor 1 by serine protease inhibitors. An effect associated with nuclear factor-kappaB inhibition

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

The reaction cycle of GroEL and GroES in chaperonin-assisted protein folding.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2732416

Novel regulatory factors of HSF-1 activation: facts and perspectives regarding their involvement in the age-associated attenuation of the heat shock response

26 November 2018

1 reference

12 December 2020

Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model

1 reference

12 December 2020

SnapShot: molecular chaperones, Part II

1 reference

12 December 2020

Trimerization of a yeast transcriptional activator via a coiled-coil motif

1 reference

12 December 2020

Effect of sodium salicylate on the human heat shock response

1 reference

12 December 2020

SnapShot: molecular chaperones, Part I

1 reference

12 December 2020

The role of ATP in the functional cycle of the DnaK chaperone system

1 reference

12 December 2020

Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23

1 reference

12 December 2020

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18519635

Identifiers

2 references

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18519635

2 references

30 April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18519635

PubMed publication ID

2 references

30 April 2017