Tubby is required for trafficking G protein-coupled receptors to neuronal cilia (Q29347244)

11 April 2017

title

Tubby is required for trafficking G protein-coupled receptors to neuronal cilia (English)

1 reference

G protein-coupled receptor

11 April 2017

main subject

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Rhodopsin

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Opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)

1 reference

Melanin-concentrating hormone receptor 1

1 reference

Somatostatin receptor 3

1 reference

Tubby bipartite transcription factor

1 reference

Opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)

1 reference

author name string

Xun Sun

1

1 reference

11 April 2017

James Haley

2

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11 April 2017

Oleg V Bulgakov

3

1 reference

11 April 2017

Xue Cai

4

1 reference

11 April 2017

James McGinnis

5

1 reference

11 April 2017

Tiansen Li

6

1 reference

11 April 2017

publication date

1 November 2012

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11 April 2017

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11 April 2017

volume

1

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11 April 2017

issue

1

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11 April 2017

page(s)

21

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OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome

11 April 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Proteomic analysis of mammalian primary cilia

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

An allele of microtubule-associated protein 1A (Mtap1a) reduces photoreceptor degeneration in Tulp1 and Tub Mutant Mice

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

The blind leading the obese: the molecular pathophysiology of a human obesity syndrome

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Analyzing real-time PCR data by the comparative C(T) method

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Tubby proteins: the plot thickens

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Microtubule-associated protein 1A is a modifier of tubby hearing (moth1).

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

A role for the Tubby-like protein 1 in rhodopsin transport

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

G-protein signaling through tubby proteins

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Targeted deletion of the tub mouse obesity gene reveals that tubby is a loss-of-function mutation

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Retinal degeneration but not obesity is observed in null mutants of the tubby-like protein 1 gene

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Implication of tubby proteins as transcription factors by structure-based functional analysis

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Retinal degeneration in tulp1-/- mice: vesicular accumulation in the interphotoreceptor matrix

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Recessive mutations in the gene encoding the tubby-like protein TULP1 in patients with Retinitis pigmentosa

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

A candidate gene for the mouse mutation tubby

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse

11 April 2017

1 reference

https://api.crossref.org/works/10.1186/2046-2530-1-21

Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance

22 April 2017

1 reference

https://api.crossref.org/works/10.1186/2046-2530-1-21

Adult type 3 adenylyl cyclase-deficient mice are obese

22 April 2017

1 reference

https://api.crossref.org/works/10.1186/2046-2530-1-21

DISC1 regulates primary cilia that display specific dopamine receptors

22 April 2017

1 reference

https://api.crossref.org/works/10.1186/2046-2530-1-21

Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memory

22 April 2017

1 reference

https://api.crossref.org/works/10.1186/2046-2530-1-21

Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain

22 April 2017

1 reference

https://api.crossref.org/works/10.1186/2046-2530-1-21

A crucial role for primary cilia in cortical morphogenesis

22 April 2017

1 reference

https://api.crossref.org/works/10.1186/2046-2530-1-21

The primary cilium: a signalling centre during vertebrate development

22 April 2017

1 reference

https://api.crossref.org/works/10.1186%2F2046-2530-1-21

22 April 2017

1 reference

https://api.crossref.org/works/10.1186%2F2046-2530-1-21

Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes

22 April 2017

1 reference

https://api.crossref.org/works/10.1186%2F2046-2530-1-21

The tubby family proteins

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

The Type 3 Adenylyl Cyclase Is Required for Novel Object Learning and Extinction of Contextual Memory: Role of cAMP Signaling in Primary Cilia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Somatostatin signaling in neuronal cilia is critical for object recognition memory.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Monitoring changes in membrane phosphatidylinositol 4,5-bisphosphate in living cells using a domain from the transcription factor tubby

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Identification of ciliary localization sequences within the third intracellular loop of G protein-coupled receptors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Focus on molecules: rootletin

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Genome-wide transcriptional analysis of flagellar regeneration in Chlamydomonas reinhardtii identifies orthologs of ciliary disease genes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Characterization of rhodopsin mis-sorting and constitutive activation in a transgenic rat model of retinitis pigmentosa.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Selective targeting of somatostatin receptor 3 to neuronal cilia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Molecular characterization of a novel tubby gene family member, TULP3, in mouse and humans

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Defective phototransductive disk membrane morphogenesis in transgenic mice expressing opsin with a mutated N-terminal domain

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Transgenic mice carrying the dominant rhodopsin mutation P347S: evidence for defective vectorial transport of rhodopsin to the outer segments

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

Mouse model for Usher syndrome: linkage mapping suggests homology to Usher type I reported at human chromosome 11p15.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

The neuronal primary cilium--an extrasynaptic signaling device

3 June 2018

1 reference

https://api.crossref.org/works/10.1186%2F2046-2530-1-21

Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F2046-2530-1-21

Polygenic control of Caenorhabditis elegans fat storage

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F2046-2530-1-21

Mice lacking melanin-concentrating hormone are hypophagic and lean

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F2046-2530-1-21

Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F2046-2530-1-21

The melanin-concentrating hormone receptor couples to multiple G proteins to activate diverse intracellular signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F2046-2530-1-21

Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F2046-2530-1-21

Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F2046-2530-1-21

Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F2046-2530-1-21

Dual and opposing roles of primary cilia in medulloblastoma development

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F2046-2530-1-21

A role for primary cilia in glutamatergic synaptic integration of adult-born neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F2046-2530-1-21

Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599646

A rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segment

26 November 2018

1 reference

12 December 2020

Allele-specific PCR assays for the tub and cpe fat mutations

1 reference

12 December 2020

Cell-specific expression of tubby gene family members (tub, Tulp1,2, and 3) in the retina

1 reference

12 December 2020

Genome-wide Linkage Analysis for Severe Obesity in French Caucasians Finds Significant Susceptibility Locus on Chromosome 19q

1 reference

12 December 2020

Cytoplasmic domain of rhodopsin is essential for post-Golgi vesicle formation in a retinal cell-free system

1 reference

12 December 2020

Identifiers

DOI

10.1186/2046-2530-1-21

1 reference

Dimensions Publication ID

1024316003

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1 reference

1 reference

1 reference