Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density (Q28975610)

21 March 2017

title

Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density (English)

1 reference

Dickkopf WNT signaling pathway inhibitor 1

21 March 2017

main subject

1 reference

Kringle containing transmembrane protein 2

GOA release 2020-03-11

1 reference

Kringle containing transmembrane protein 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

9

Heiner Westphal

1 reference

21 March 2017

Kristina Ellwanger

1

1 reference

21 March 2017

Hiroaki Saito

2

1 reference

21 March 2017

Philippe Clément-Lacroix

3

1 reference

21 March 2017

Nicole Maltry

4

1 reference

21 March 2017

Joachim Niedermeyer

5

1 reference

21 March 2017

Woon Kyu Lee

6

1 reference

21 March 2017

Roland Baron

7

1 reference

21 March 2017

Georges Rawadi

8

1 reference

21 March 2017

Christof Niehrs

10

1 reference

21 March 2017

language of work or name

English

0 references

publication date

1 August 2008

1 reference

Molecular and Cellular Biology

21 March 2017

published in

1 reference

21 March 2017

volume

28

1 reference

21 March 2017

issue

15

1 reference

21 March 2017

page(s)

4875–4882

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R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

21 March 2017

cites work

1 reference

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23 March 2017

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R-spondin3 is required for mouse placental development

23 March 2017

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Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression

23 March 2017

1 reference

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Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction

23 March 2017

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Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function

23 March 2017

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23 March 2017

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En1 and Wnt7a interact with Dkk1 during limb development in the mouse

23 March 2017

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23 March 2017

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Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb

23 March 2017

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High bone mass in mice expressing a mutant LRP5 gene

23 March 2017

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Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge

23 March 2017

1 reference

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Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling

23 March 2017

1 reference

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Functions of FGF signalling from the apical ectodermal ridge in limb development

23 March 2017

1 reference

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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

23 March 2017

1 reference

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High bone density due to a mutation in LDL-receptor-related protein 5

23 March 2017

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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

23 March 2017

1 reference

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Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

23 March 2017

1 reference

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Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse

23 March 2017

1 reference

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Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

23 March 2017

1 reference

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Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein

23 March 2017

1 reference

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Wnt signaling: a common theme in animal development

23 March 2017

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WNT and beta-catenin signalling: diseases and therapies

7 April 2017

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Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee

7 April 2017

1 reference

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Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493355

Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493355

Function and biological roles of the Dickkopf family of Wnt modulators

3 June 2018

1 reference

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Molecular bases of the regulation of bone remodeling by the canonical Wnt signaling pathway.

3 June 2018

1 reference

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Regulation of bone mass by Wnt signaling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493355

Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493355

Wnt signaling in disease and in development

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493355

A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor-deficient mice

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493355

Wnt signalling during limb development

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493355

Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493355

The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493355

Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493355

Context-dependent activation or inhibition of Wnt-beta-catenin signaling by Kremen

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493355

Roles of Dickkopf-1 and its receptor Kremen1 during embryonic implantation in mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493355

R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493355

The Wnt signaling antagonist Kremen1 is required for development of thymic architecture

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493355

Hypomorphic expression of Dkk1 in the doubleridge mouse: dose dependence and compensatory interactions with Lrp6.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493355

Doubleridge, a mouse mutant with defective compaction of the apical ectodermal ridge and normal dorsal-ventral patterning of the limb.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493355

Applications of micro-CT and MR microscopy to study pre-clinical models of osteoporosis and osteoarthritis.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493355

Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbs.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493355

Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass

26 November 2018

1 reference

12 December 2020

Wnt signaling and the regulation of bone mass

1 reference

12 December 2020

Ectoderm-mesenchyme and mesenchyme-mesenchyme interactions regulate Msx-1 expression and cellular differentiation in the murine limb bud

1 reference

12 December 2020

A microtomographic system for the nondestructive evaluation of bone architecture

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.00222-08

1 reference

1 reference

1 reference

1 reference