DNA methyltransferase 3 alpha (Q28559175)

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mammalian protein found in Rattus norvegicus

DNA (cytosine-5)-methyltransferase 3A
DNA (cytosine-5-)-methyltransferase 3 alpha
Dnmt3a
DNA methyltransferase 3A
cysteine methyltransferase DNMT3A

Language	Label	Description	Also known as
English	DNA methyltransferase 3 alpha	mammalian protein found in Rattus norvegicus	DNA (cytosine-5)-methyltransferase 3A DNA (cytosine-5-)-methyltransferase 3 alpha Dnmt3a DNA methyltransferase 3A cysteine methyltransferase DNMT3A

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

S-adenosyl-L-methionine-dependent methyltransferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q1LZ53

DNA (cytosine-5)-methyltransferase 3A

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q1LZ53

PWWP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

ADD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DNA methylase, C-5 cytosine-specific, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

determination method or standard

3 references

14 February 2019

A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

DNA (cytosine-5-)-methyltransferase activity

determination method or standard

3 references

14 February 2019

A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

transcription factor binding

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

DNA-methyltransferase activity

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

transferase activity

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

identical protein binding

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

metal ion binding

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

chromosome, centromeric region

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

heterochromatin

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

determination method or standard

3 references

14 February 2019

A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

determination method or standard

4 references

14 February 2019

A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

14 February 2019

Cellular epigenetic modifications of neural stem cell differentiation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

biological process

negative regulation of transcription by RNA polymerase II

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

mitotic cell cycle

determination method or standard

1 reference

14 February 2019

Phenotypic switching induced by damaged matrix is associated with DNA methyltransferase 3A (DNMT3A) activity and nuclear localization in smooth muscle cells (SMC)

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

DNA methylation

determination method or standard

3 references

14 February 2019

A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

chromatin organization

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

DNA methylation-dependent heterochromatin assembly

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

regulation of gene expression by genetic imprinting

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

spermatogenesis

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

determination method or standard

1 reference

14 February 2019

A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

response to toxic substance

determination method or standard

1 reference

14 February 2019

Effects of bromopropane exposure on expression of DNA methyltransferases and level of histone acetylation in testis of male rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

response to ionizing radiation

determination method or standard

1 reference

14 February 2019

Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

response to lead ion

determination method or standard

1 reference

14 February 2019

Influence of developmental lead exposure on expression of DNA methyltransferases and methyl cytosine-binding proteins in hippocampus

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

regulation of gene expression

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

positive regulation of cell death

determination method or standard

1 reference

14 February 2019

MicroRNA miR-29c down-regulation leading to de-repression of its target DNA methyltransferase 3a promotes ischemic brain damage

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

neuron differentiation

determination method or standard

1 reference

14 February 2019

Cellular epigenetic modifications of neural stem cell differentiation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

response to nutrient levels

determination method or standard

1 reference

14 February 2019

A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

response to estradiol

determination method or standard

1 reference

14 February 2019

Perinatal programming of adult rat germ cell death after exposure to xenoestrogens: role of microRNA miR-29 family in the down-regulation of DNA methyltransferases and Mcl-1

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

DNA methylation on cytosine

determination method or standard

1 reference

14 February 2019

Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

response to vitamin A

determination method or standard

1 reference

14 February 2019

Alteration in methylation pattern of GATA-4 promoter region in vitamin A-deficient offspring's heart

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

response to cocaine

determination method or standard

1 reference

14 February 2019

Cocaine represses protein phosphatase-1Cβ through DNA methylation and Methyl-CpG Binding Protein-2 recruitment in adult rat brain

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

DNA methylation involved in embryo development

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

DNA methylation involved in gamete generation

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

response to ethanol

determination method or standard

1 reference

14 February 2019

Effects of acute ethanol exposure on anxiety measures and epigenetic modifiers in the extended amygdala of adolescent rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

cellular response to amino acid stimulus

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

cellular response to ethanol

determination method or standard

1 reference

14 February 2019

Regulation of DNA methylation by ethanol induces tissue plasminogen activator expression in astrocytes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

cellular response to hypoxia

determination method or standard

1 reference

14 February 2019

Phenotypic switching induced by damaged matrix is associated with DNA methyltransferase 3A (DNMT3A) activity and nuclear localization in smooth muscle cells (SMC)

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

C-5 methylation of cytosine

determination method or standard

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

hepatocyte apoptotic process

determination method or standard

1 reference

14 February 2019

DNA methyltransferase 3a expression decreases during apoptosis in primary cultures of hepatocytes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q1LZ53

determination method or standard

DNA methylase, C-5 cytosine-specific, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q1LZ53

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q1LZ53

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q1LZ53

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSRNOP00000046524

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000046524

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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