Phase II open label study of valproic acid in spinal muscular atrophy (Q28475498)

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28 January 2020

title

Phase II open label study of valproic acid in spinal muscular atrophy (English)

1 reference

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28 January 2020

main subject

spinal muscular atrophy

1 reference

1 reference

Kristin J. Krosschell

11

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28 January 2020

Louise R Simard

17

1 reference

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28 January 2020

1

Kathryn J Swoboda

1 reference

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28 January 2020

author name string

Charles B Scott

2

1 reference

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28 January 2020

Sandra P Reyna

3

1 reference

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28 January 2020

Thomas W Prior

4

1 reference

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28 January 2020

Bernard LaSalle

5

1 reference

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28 January 2020

Susan L Sorenson

6

1 reference

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28 January 2020

Janine Wood

7

1 reference

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28 January 2020

Gyula Acsadi

8

1 reference

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28 January 2020

Thomas O Crawford

9

1 reference

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28 January 2020

John T Kissel

10

1 reference

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28 January 2020

Guy D'Anjou

12

1 reference

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28 January 2020

Mark B Bromberg

13

1 reference

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28 January 2020

Mary K Schroth

14

1 reference

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28 January 2020

Gary M Chan

15

1 reference

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28 January 2020

Bakri Elsheikh

16

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28 January 2020

language of work or name

English

0 references

publication date

14 May 2009

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28 January 2020

1 reference

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28 January 2020

volume

4

1 reference

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28 January 2020

issue

5

1 reference

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28 January 2020

page(s)

e5268

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Creative Commons Attribution 4.0 International

28 January 2020

copyright license

start time

14 May 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Multiple therapeutic effects of valproic acid in spinal muscular atrophy model mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

A modified Hammersmith functional motor scale for use in multi-center research on spinal muscular atrophy

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Hydroxyurea enhances SMN2 gene expression in spinal muscular atrophy cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Phenylbutyrate increases SMN gene expression in spinal muscular atrophy patients

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Phenylbutyrate increases SMN expression in vitro: relevance for treatment of spinal muscular atrophy

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Valproic acid increases the SMN2 protein level: a well-known drug as a potential therapy for spinal muscular atrophy

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

The Hammersmith functional motor scale for children with spinal muscular atrophy: a scale to test ability and monitor progress in children with limited ambulation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Abnormal fatty acid metabolism in childhood spinal muscular atrophy

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Fatty acid oxidation abnormalities in childhood-onset spinal muscular atrophy: primary or secondary defect(s)?

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Population frequencies of inherited neuromuscular diseases—A world survey

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Identification and characterization of a spinal muscular atrophy-determining gene

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Preclinical validation of a multiplex real-time assay to quantify SMN mRNA in patients with SMA

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

SMN mRNA and protein levels in peripheral blood: biomarkers for SMA clinical trials

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

The survival of motor neurons protein determines the capacity for snRNP assembly: biochemical deficiency in spinal muscular atrophy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Natural history of denervation in SMA: relation to age, SMN2 copy number, and function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

The role of histone acetylation in SMN gene expression.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Valproic acid increases SMN levels in spinal muscular atrophy patient cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Quantitative analyses of SMN1 and SMN2 based on real-time lightCycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Treatment of spinal muscular atrophy by sodium butyrate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Correlation between severity and SMN protein level in spinal muscular atrophy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Spinal muscular atrophies: recent insights and impact on molecular diagnosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

A hungarian study on Werdnig-Hoffmann disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Incidence, prevalence, and gene frequency studies of chronic childhood spinal muscular atrophy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Mildly affected patients with spinal muscular atrophy are partially protected by an increased SMN2 copy number

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Motor unit number estimation in infants and children with spinal muscular atrophy

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

The genetic component in child mortality

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680034

Molecular analysis of spinal muscular atrophy and modification of the phenotype by SMN2.

2 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005268

Homozygous SMN1 deletions in unaffected family members and modification of the phenotype by SMN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005268

Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005268

Benefit of valproic acid in suppressing disease progression of ALS model mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005268

Additive neuroprotective effects of a histone deacetylase inhibitor and a catalytic antioxidant in a transgenic mouse model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005268

Valproic acid treatment in six patients with spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005268

The effect of valproate on bone mineral density in adult epileptic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005268

Effect of carbamazepine and valproate on bone mineral density

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005268

Fractures in children with cerebral palsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005268

Epidemiology of neuromuscular disorders in the under-20 population in Bologna province, Italy

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005268

Reliability of the Hammersmith functional motor scale for spinal muscular atrophy in a multicentric study

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005268

Carnitine deficiency: a possible mechanism for valproate hepatotoxicity

21 January 2018

1 reference

12 December 2020

Carnitine-dependent changes of metabolic fuel consumption during long-term treatment with valproic acid

1 reference

12 December 2020

Valproic Acid Promotes Neurite Outgrowth in PC12 Cells independent from Regulation of the Survival of Motoneuron Protein

1 reference

12 December 2020

In vivo activation of SMN in spinal muscular atrophy carriers and patients treated with valproate

1 reference

12 December 2020

Effect of carbamezapine and valproic acid on bone mineral density, IGF-I and IGFBP-3

1 reference

12 December 2020

Valproate may improve strength and function in patients with type III/IV spinal muscle atrophy

1 reference

12 December 2020

Establishing a standardized therapeutic testing protocol for spinal muscular atrophy

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0005268

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19440247%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

ADS bibcode

2009PLoSO...4.5268S

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19440247%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

PubMed publication ID

19440247

2 references