Par4 is a coactivator for a splice isoform-specific transcriptional activation domain in WT1 (Q28346512)

1

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V Schumacher

2

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B Royer-Pokora

3

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S G Roberts

WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes

4

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language of work or name

English

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publication date

1 February 2001

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published in

Genes & Development

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volume

15

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issue

3

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page(s)

328-39

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cites work

1 reference

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Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1

20 March 2017

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Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70

20 March 2017

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A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1

20 March 2017

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The Wilms' tumor gene product WT1 activates or suppresses transcription through separate functional domains

20 March 2017

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WT-1 is required for early kidney development

20 March 2017

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WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis

20 March 2017

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Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1

20 March 2017

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Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

20 March 2017

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Mechanisms of action of transcription activation and repression domains

20 March 2017

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Regulation of the Wilms' tumour suppressor protein transcriptional activation domain.

29 September 2017

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Presence of WT1, the Wilm's tumor suppressor gene product, in nuclear poly(A)(+) ribonucleoprotein

29 September 2017

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The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin

29 September 2017

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WT1: what has the last decade told us?

29 September 2017

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The role of human TFIIB in transcription start site selection in vitro and in vivo

29 September 2017

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Tumor-associated WT1 missense mutants indicate that transcriptional activation by WT1 is critical for growth control

29 September 2017

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Multiple roles for the Wilms' tumor suppressor, WT1.

29 September 2017

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Analysis of WT1 target gene expression in stably transfected cell lines

29 September 2017

1 reference

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E1B 55K sequesters WT1 along with p53 within a cytoplasmic body in adenovirus-transformed kidney cells.

29 September 2017

1 reference

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Software and database for the analysis of mutations in the human WT1 gene

29 September 2017

1 reference

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Donor splice-site mutations in WT1 are responsible for Frasier syndrome

29 September 2017

1 reference

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Differential splicing of exon 5 of the Wilms tumour (WT1) gene

29 September 2017

1 reference

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Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of stromal-predominant histology

29 September 2017

1 reference

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Transcriptional activation of the syndecan-1 promoter by the Wilms' tumor protein WT1.

29 September 2017

1 reference

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RNA binding by the Wilms tumor suppressor zinc finger proteins.

29 September 2017

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The WT1 Wilms' tumor suppressor gene: how much do we really know?

29 September 2017

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Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312625

Repression of the transforming growth factor-beta 1 gene by the Wilms' tumor suppressor WT1 gene product

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312625

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

29 September 2017

1 reference

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WT1-mediated transcriptional activation is inhibited by dominant negative mutant proteins.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312625

The evolution of WT1 sequence and expression pattern in the vertebrates

29 September 2017

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WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312625

The Wilms Tumour GeneWT1in Leukaemia

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312625

Products of alternatively spliced transcripts of the Wilms' tumor suppressor gene, wt1, have altered DNA binding specificity and regulate transcription in different ways.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312625

Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312625

Transcriptional repression mediated by the WT1 Wilms tumor gene product

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312625

Overproduction and single-step purification of GAL4 fusion proteins from Escherichia coli.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312625

Analysis of native WT1 protein from frozen human kidney and Wilms' tumors

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312625

Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312625

Wilms' tumor 1-KTS isoforms induce p53-independent apoptosis that can be partially rescued by expression of the epidermal growth factor receptor or the insulin receptor.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312625

Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1

27 November 2018

1 reference

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WT1--more than a transcription factor?

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Mutation analysis of the WT1 gene in sporadic childhood leukaemia

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Transactivation of the WT1 antisense promoter is unique to the WT1[+/−] isoform

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Binding of general transcription factor TFIIB to an acidic activating region

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Apoptosis mediated by a novel leucine zipper protein Par-4

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Induction of p21 by the Wilms' tumor suppressor gene WT1

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The Wilms tumor suppressor gene WT1 induces G1 arrest and apoptosis in myeloblastic leukemia M1 cells

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Constitutional WT1 mutations in Wilms' tumor patients

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A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing

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Identifiers

DOI

10.1101/GAD.185901

1 reference

1 reference

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PubMed publication ID

11159913

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