Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor (Q28343653)

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1 November 2019

title

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor (English)

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1 November 2019

5

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1 November 2019

author name string

P Andrade-Gordon

1

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1 November 2019

B E Maryanoff

2

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1 November 2019

C K Derian

3

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1 November 2019

H C Zhang

4

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1 November 2019

A L Darrow

6

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1 November 2019

A J Eckardt

7

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1 November 2019

W J Hoekstra

8

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1 November 2019

D F McComsey

9

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1 November 2019

D Oksenberg

10

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1 November 2019

E E Reynolds

11

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1 November 2019

R J Santulli

12

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1 November 2019

R M Scarborough

13

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C E Smith

14

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K B White

15

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1 November 2019

language of work or name

English

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publication date

1 October 1999

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1 November 2019

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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volume

96

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issue

22

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page(s)

12257-12262

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Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

1 November 2019

cites work

1 reference

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A dual thrombin receptor system for platelet activation

20 March 2017

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Cloning and characterization of human protease-activated receptor 4

20 March 2017

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Protease-activated receptor 3 is a second thrombin receptor in humans

20 March 2017

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Molecular cloning of a potential proteinase activated receptor

20 March 2017

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Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2

20 March 2017

1 reference

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Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling

20 March 2017

1 reference

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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

20 March 2017

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Thrombin receptor function and cardiovascular disease

20 March 2017

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Heterocycle-peptide hybrid compounds. Aminotriazole-containing agonists of the thrombin receptor (PAR-1).

29 September 2017

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Thrombin receptor activation by thrombin and receptor-derived peptides in platelet and CHRF-288 cell membranes: receptor-stimulated GTPase and evaluation of agonists and partial agonists

29 September 2017

1 reference

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Structure and function of G protein-coupled receptors

29 September 2017

1 reference

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The mouse proteinase-activated receptor-2 cDNA and gene. Molecular cloning and functional expression

29 September 2017

1 reference

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Receptors and G proteins as primary components of transmembrane signal transduction. Part 1. G-protein-coupled receptors: structure and function.

29 September 2017

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The family of G‐protein‐coupled receptors

29 September 2017

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Expression of smooth muscle-specific alpha-isoactin in cultured vascular smooth muscle cells: relationship between growth and cytodifferentiation

29 September 2017

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Structure and function of G protein coupled receptors

29 September 2017

1 reference

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Modeling of G-protein-coupled receptors: application to dopamine, adrenaline, serotonin, acetylcholine, and mammalian opsin receptors

29 September 2017

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Biological consequences of thrombin receptor deficiency in mice.

29 September 2017

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Response of a human megakaryocytic cell line to thrombin: increase in intracellular free calcium and mitogen release

2 June 2018

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Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function

2 June 2018

1 reference

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Minimal sequence requirement of thrombin receptor agonist peptide

2 June 2018

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Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides

2 June 2018

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Structure-activity studies of the thrombin receptor activating peptide

2 June 2018

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12 December 2020

Essential groups in synthetic agonist peptides for activation of the platelet thrombin receptor

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12 December 2020

The alpha and omega of G-protein coupled receptors: a novel method for classification. Part 1

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12 December 2020

Inhibition of thrombin and SFLLR-peptide stimulation of platelet aggregation, phospholipase A2 and Na+/H+ exchange by a thrombin receptor antagonist

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12 December 2020

The thrombin receptor

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12 December 2020

Macrocyclic hexapeptide analogues of the thrombin receptor (PAR-1) activation motif SFLLRN

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12 December 2020

'Tethered ligand' derived pentapeptide agonists of thrombin receptor: a study of side chain requirements for human platelet activation and GTPase stimulation

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12 December 2020

Thrombin receptor structure and function

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12 December 2020

Development of potent thrombin receptor antagonist peptides

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12 December 2020

Thrombin receptor (PAR-1) antagonists. Heterocycle-based peptidomimetics of the SFLLR agonist motif

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12 December 2020

Development of a potent thrombin receptor ligand

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12 December 2020

Identifiers

DOI

10.1073/PNAS.96.22.12257

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10535908%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

0 references

1 reference

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1 November 2019

PubMed publication ID

10535908

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