The IRS-signalling system: a network of docking proteins that mediate insulin action (Q28272481)

Molecular and Cellular Biochemistry

Europe PubMed Central

title

The IRS-signalling system: a network of docking proteins that mediate insulin action (English)

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M F White

1

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language of work or name

English

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publication date

May 1998

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published in

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volume

182

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issue

1-2

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page(s)

3-11

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cites work

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Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin

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A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene

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corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

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Mechanism of activation of protein kinase B by insulin and IGF-1

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Interleukin 1 (IL1) and tumour necrosis factor (TNF) signal transduction

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

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Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase

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Association of insulin receptor substrate-1 with integrins

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Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

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DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.

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Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor

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Protein modules and signalling networks

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The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation

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Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok

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Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

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The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

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Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta

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Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

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A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies

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IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

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Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation

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Insulin signaling in mice expressing reduced levels of Syp.

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Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

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The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family

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Association of insulin receptor substrate 1 with simian virus 40 large T antigen

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Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain

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Insulin-mediated targeting of phosphatidylinositol 3-kinase to GLUT4-containing vesicles

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Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells

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Tumor necrosis factor alpha: a key component of the obesity-diabetes link

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p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells

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YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites

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Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor

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Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

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Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice

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How receptor tyrosine kinases activate Ras.

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Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK

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Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

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SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases

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Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

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The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. Modulation by insulin growth factor-I (IGF) and enhanced IGF-I signaling

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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PI 3-kinase: structural and functional analysis of intersubunit interactions

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Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells

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Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

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The function of GRB2 in linking the insulin receptor to Ras signaling pathways

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Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor

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Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction

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Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase

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The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling

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Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase

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Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1.

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Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1.

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Akt signaling: linking membrane events to life and death decisions

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14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner

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12 December 2020

Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit

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12 December 2020

Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport

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The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action.

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12 December 2020

Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene

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12 December 2020

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

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12 December 2020

Regulation of chemotaxis by the platelet-derived growth factor receptor-beta

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12 December 2020

Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle

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The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells

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12 December 2020

Role of IRS-2 in insulin and cytokine signalling

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12 December 2020

The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp

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12 December 2020

Role of IRS-1-GRB-2 complexes in insulin signaling

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The 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells

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Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2.

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12 December 2020

Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal localization of genes

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Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation

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12 December 2020

Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.

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12 December 2020

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

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12 December 2020