On the road to immortality: hTERT upregulation in cancer cells (Q28257238)

Switching and signaling at the telomere

Europe PubMed Central

title

On the road to immortality: hTERT upregulation in cancer cells (English)

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author name string

Ralf Janknecht

series ordinal

1

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language of work or name

English

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publication date

23 April 2004

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published in

FEBS Letters

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volume

564

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issue

1-2

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page(s)

9-13

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Association between telomere length in blood and mortality in people aged 60 years or older

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

The telomerase reverse transcriptase: components and regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Telomerase as tumor marker

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Telomerase regulation: not just flipping the switch

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Extension of life-span by introduction of telomerase into normal human cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Creation of human tumour cells with defined genetic elements

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Inhibition of telomerase limits the growth of human cancer cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Transformation of normal human cells in the absence of telomerase activation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Signaling through estrogen receptors modulates telomerase activity in human prostate cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Tamoxifen regulates human telomerase reverse transcriptase (hTERT) gene expression differently in breast and endometrial cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Effects of androgens on telomerase activity in normal and malignant prostate cells in vitro.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

In vivo regulation of hTERT expression and telomerase activity by androgen.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Retinoic acid receptor alpha and retinoid-X receptor-specific agonists synergistically target telomerase expression and induce tumor cell death.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Function and regulation of the transcription factors of the Myc/Max/Mad network

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Direct activation of TERT transcription by c-MYC.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Identification of Mad as a repressor of the human telomerase (hTERT) gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Induction of endogenous telomerase (hTERT) by c-Myc in WI-38 fibroblasts transformed with specific genetic elements

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

c-myc is a downstream target of the Smad pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Cell cycle-dependent modulation of telomerase activity in tumor cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Transforming growth factor beta triggers two independent-senescence programs in cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Inhibition of human telomerase reverse transcriptase gene expression by BRCA1 in human ovarian cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

BRCA1 Inhibition of Telomerase Activity in Cultured Cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Variant forms of upstream stimulatory factors (USFs) control the promoter activity of hTERT, the human gene encoding the catalytic subunit of telomerase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Downstream E-box-mediated regulation of the human telomerase reverse transcriptase (hTERT) gene transcription: evidence for an endogenous mechanism of transcriptional repression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Identification of a novel transcription factor binding element involved in the regulation by differentiation of the human telomerase (hTERT) promoter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

The ETS-domain transcription factor family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Untangling the ErbB signalling network

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Direct activation of telomerase by EGF through Ets-mediated transactivation of TERT via MAP kinase signaling pathway.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Role of Ets/Id proteins for telomerase regulation in human cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Upregulation of the Catalytic Telomerase Subunit by the Transcription Factor ER81 and Oncogenic HER2/Neu, Ras, or Raf.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

cis-Activation of the human telomerase gene (hTERT) by the hepatitis B virus genome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Integrations of the hepatitis B virus (HBV) and human papillomavirus (HPV) into the human telomerase reverse transcriptase (hTERT) gene in liver and cervical cancers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Telomerase activation by human papillomavirus type 16 E6 protein: induction of human telomerase reverse transcriptase expression through Myc and GC-rich Sp1 binding sites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

E box-dependent activation of telomerase by human papillomavirus type 16 E6 does not require induction of c-myc

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Tumor-specific activation of hTERT-derived promoters by tumor suppressive E1A-mutants involves recruitment of p300/CBP/HAT and suppression of HDAC-1 and defines a combined tumor targeting and suppression system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus transactivates the telomerase reverse transcriptase promoter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Inactivation of hTERT transcription by Tax.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Human papillomavirus E2 down-regulates the human telomerase reverse transcriptase promoter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Evolving views of telomerase and cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

CpG island methylation of the hTERT promoter is associated with lower telomerase activity in B-cell lymphocytic leukemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Hypermethylation of the human telomerase catalytic subunit (hTERT) gene correlates with telomerase activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Regulation of the human telomerase reverse transcriptase gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

The Wilms' tumor 1 tumor suppressor gene represses transcription of the human telomerase reverse transcriptase gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: possible role of MZF-2 in transcriptional repression of hTERT.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

E2F-1 represses transcription of the human telomerase reverse transcriptase gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Opposing regulatory roles of E2F in human telomerase reverse transcriptase (hTERT) gene expression in human tumor and normal somatic cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Intact functional domains of the retinoblastoma gene product (pRb) are required for downregulation of telomerase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Rb and E2F-1 regulate telomerase activity in human cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Multiple tumor suppressor pathways negatively regulate telomerase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4

Inhibition of the epidermal growth factor receptor suppresses telomerase activity in HSC-1 human cutaneous squamous cell carcinoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900356-4