BRAF activates and physically interacts with PAK to regulate cell motility (Q28248127)

1

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Motoyasu Saji

2

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Xiaoli Zhang

3

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Christina M Knippler

4

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Lawrence S Kirschner

5

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Soledad Fernandez

6

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Matthew D Ringel

PAK signalling during the development and progression of cancer

7

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language of work or name

English

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publication date

2014

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published in

Endocrine-Related Cancer

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volume

21

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issue

6

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page(s)

865-77

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cites work

1 reference

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PAK in Alzheimer disease, Huntington disease and X-linked mental retardation

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PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling

20 March 2017

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The BRAFV600E oncogene induces transforming growth factor beta secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancer

20 March 2017

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Quantitative colocalization analysis of multicolor confocal immunofluorescence microscopy images: pushing pixels to explore biological phenomena

20 March 2017

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2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase

20 March 2017

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The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells

20 March 2017

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PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

20 March 2017

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Scaffolding function of PAK in the PDK1-Akt pathway

20 March 2017

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Human Protein Reference Database--2009 update

20 March 2017

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7 April 2017

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TERT promoter mutations and their association with BRAF V600E mutation and aggressive clinicopathological characteristics of thyroid cancer

7 April 2017

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Localization of CaSR antagonists in CaSR-expressing medullary thyroid cancer

29 September 2017

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Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.

29 September 2017

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PAK1 regulates breast cancer cell invasion through secretion of matrix metalloproteinases in response to prolactin and three-dimensional collagen IV.

29 September 2017

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Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors.

29 September 2017

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p21-activated kinase 1 (PAK1) can promote ERK activation in a kinase-independent manner

29 September 2017

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Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer

29 September 2017

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Vemurafenib enhances MHC induction in BRAF(V600E) homozygous melanoma cells

29 September 2017

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Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas.

29 September 2017

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Comparison with published systems of a new staging system for papillary and follicular thyroid carcinoma.

29 September 2017

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p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model.

29 September 2017

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Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation

29 September 2017

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BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study

29 September 2017

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Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

29 September 2017

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BRAFV600E and Microenvironment in Thyroid Cancer: A Functional Link to Drive Cancer Progression

29 September 2017

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Progression of BRAF-induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFβ signaling

29 September 2017

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Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A.

29 September 2017

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Signalling to cancer cell invasion through PAK family kinases

29 September 2017

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Group I p21-activated kinases regulate thyroid cancer cell migration and are overexpressed and activated in thyroid cancer invasion

29 September 2017

1 reference

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Molecular markers of aggressiveness of thyroid cancer

29 September 2017

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Signaling dynamics of the KSR1 scaffold complex

29 September 2017

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PAK kinase regulates Rac GTPase and is a potential target in human schwannomas

29 September 2017

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Phase II trial of sorafenib in metastatic thyroid cancer

29 September 2017

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Molecular pathology of thyroid cancer: diagnostic and clinical implications

29 September 2017

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Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification

29 September 2017

1 reference

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BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications

29 September 2017

1 reference

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Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487662

Molecular mechanisms involved in differentiated thyroid cancer invasion and metastasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487662

All-trans-retinoic acid modulates expression levels of thyroglobulin and cytokines in a new human poorly differentiated papillary thyroid carcinoma cell line, KTC-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487662

Constitutive activation of Mek1 by mutation of serine phosphorylation sites

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487662

Description of a human papillary thyroid carcinoma cell line. Morphologic study and expression of tumoral markers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487662

Growth regulation of normal thyroids and thyroid tumors in man.

2 June 2018

1 reference

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Colocalization of fluorescent markers in confocal microscope images of plant cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487662

Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487662

BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487662

Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487662

The active conformation of the PAK1 kinase domain

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487662

Overexpression and overactivation of Akt in thyroid carcinoma

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25228413