Engineering polydactyl zinc-finger transcription factors (Q28217078)

1997 Albert Lasker Award for Basic Medical Research. Control of gene transcription: an outline

Europe PubMed Central

title

Engineering polydactyl zinc-finger transcription factors (English)

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2

Carlos F Barbas

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author name string

Roger R Beerli

series ordinal

1

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language of work or name

English

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publication date

February 2002

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published in

Nature Biotechnology

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volume

20

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issue

2

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page(s)

135-41

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cites work

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Active repression mechanisms of eukaryotic transcription repressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

The Sequence of the Human Genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Initial sequencing and analysis of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Design of novel sequence-specific DNA-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Toward rules relating zinc finger protein sequences and DNA binding site preferences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Zinc finger-DNA recognition: analysis of base specificity by site-directed mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Designing zinc-finger ADR1 mutants with altered specificity of DNA binding to T in UAS1 sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Zinc finger phage: affinity selection of fingers with new DNA-binding specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Toward a code for the interactions of zinc fingers with DNA: selection of randomized fingers displayed on phage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

In vitro selection of zinc fingers with altered DNA-binding specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Building zinc fingers by selection: toward a therapeutic application

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Design of polydactyl zinc-finger proteins for unique addressing within complex genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Chemically regulated zinc finger transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Combining structure-based design with phage display to create new Cys(2)His(2) zinc finger dimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Dimerization of zinc fingers mediated by peptides evolved in vitro from random sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Positive and negative regulation of endogenous genes by designed transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Getting a handhold on DNA: design of poly-zinc finger proteins with femtomolar dissociation constants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Improved DNA binding specificity from polyzinc finger peptides by using strings of two-finger units

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Quantifying DNA-protein interactions by double-stranded DNA arrays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Exploring the DNA-binding specificities of zinc fingers with DNA microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Target Detection Assay (TDA): a versatile procedure to determine DNA binding sites as demonstrated on SP1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Design of polyzinc finger peptides with structured linkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

A 2.2 A resolution crystal structure of a designed zinc finger protein bound to DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Synergy between adjacent zinc fingers in sequence-specific DNA recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Comprehensive DNA recognition through concerted interactions from adjacent zinc fingers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

In vivo selection of basic region-leucine zipper proteins with altered DNA-binding specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

A bacterial two-hybrid selection system for studying protein-DNA and protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

A genetic screen identifies a cellular regulator of adeno-associated virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Molecular dissection of DNA sequences and factors involved in slow muscle-specific transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Krüppel-associated boxes are potent transcriptional repression domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Transcriptional repression by zinc finger peptides. Exploring the potential for applications in gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Zinc finger proteins as designer transcription factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Design of TATA box-binding protein/zinc finger fusions for targeted regulation of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Transcriptional activation by recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Synthetic zinc finger transcription factor action at an endogenous chromosomal site. Activation of the human erythropoietin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

A regulatory system for use in gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Chimeric receptors as gene switches

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

A versatile framework for the design of ligand-dependent, transgene-specific transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Stimulation of homologous recombination through targeted cleavage by chimeric nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Expressing the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

Analysis of zinc fingers optimized via phage display: evaluating the utility of a recognition code

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135

inferred from DOI database lookup

7 January 2021

based on heuristic

The new biology. Genomics fosters a "systems approach" and collaborations between academic, government, and industry scientists

1 reference

https://api.crossref.org/works/10.1038%2FNBT0202-135