LKB1--a master tumour suppressor of the small intestine and beyond (Q28208312)

Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits; a syndrome of diagnostic significance

Europe PubMed Central

title

LKB1--a master tumour suppressor of the small intestine and beyond (English)

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author name string

Lina I Yoo

series ordinal

1

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Daniel C Chung

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2

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Junying Yuan

series ordinal

3

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language of work or name

English

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publication date

July 2002

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published in

Nature Reviews Cancer

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volume

2

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issue

7

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page(s)

529-35

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cites work

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Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase

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Cloning and characterization of a novel serine/threonine protein kinase expressed in early Xenopus embryos

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LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo

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The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death

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Loss of cytoplasmic retention ability of mutant LKB1 found in Peutz-Jeghers syndrome patients

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The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase

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Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

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Ovarian sex cord tumor with annular tubules: review of 74 cases including 27 with Peutz-Jeghers syndrome and four with adenoma malignum of the cervix

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LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest

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The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

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