Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics (Q28141424)

Prodrug activation enzymes in cancer gene therapy

Europe PubMed Central

title

Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics (English)

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M A Kay

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J C Glorioso

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2

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L Naldini

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3

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language of work or name

English

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publication date

January 2001

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published in

Nature Medicine

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volume

7

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issue

1

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page(s)

33-40

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cites work

1 reference

7 January 2021

Progress in antiangiogenic gene therapy of cancer

1 reference

7 January 2021

Gene therapy for cancer: what have we done and where are we going?

1 reference

7 January 2021

Gene delivery from replication-selective viruses: arming guided missiles in the war against cancer

1 reference

7 January 2021

Replication-selective adenoviruses as oncolytic agents

1 reference

7 January 2021

Regulated gene expression systems

1 reference

7 January 2021

Human gene marker/therapy clinical protocols

1 reference

7 January 2021

Characterization of a replication-competent retrovirus resulting from recombination of packaging and vector sequences

1 reference

7 January 2021

No retroviremia or pathology in long-term follow-up of monkeys exposed to a murine amphotropic retrovirus

1 reference

7 January 2021

Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells

1 reference

7 January 2021

Integration of murine leukemia virus DNA depends on mitosis

1 reference

7 January 2021

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection

1 reference

7 January 2021

Gene therapy using hematopoietic stem cells: Sisyphus approaches the crest

1 reference

7 January 2021

HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia

1 reference

7 January 2021

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

1 reference

7 January 2021

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

1 reference

7 January 2021

A third-generation lentivirus vector with a conditional packaging system

1 reference

7 January 2021

Development of a self-inactivating lentivirus vector.

1 reference

7 January 2021

Interaction of human immunodeficiency virus-derived vectors with wild-type virus in transduced cells.

1 reference

7 January 2021

Gene transfer vectors derived from equine infectious anemia virus

1 reference

7 January 2021

Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors

1 reference

7 January 2021

Stable gene transfer to the nervous system using a non-primate lentiviral vector

1 reference

7 January 2021

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector

1 reference

7 January 2021

Lentiviral gene transfer to the nonhuman primate brain

1 reference

7 January 2021

Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer

1 reference

7 January 2021

Reversal of pathology in the entire brain of mucopolysaccharidosis type VII mice after lentivirus-mediated gene transfer.

1 reference

7 January 2021

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

1 reference

7 January 2021

Pseudotyped human lentiviral vector-mediated gene transfer to airway epithelia in vivo.

1 reference

7 January 2021

Efficient lentiviral transduction of liver requires cell cycling in vivo

1 reference

7 January 2021

Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors

1 reference

7 January 2021

Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors

1 reference

7 January 2021

Marking and gene expression by a lentivirus vector in transplanted human and nonhuman primate CD34(+) cells

1 reference

7 January 2021

Transduction of Human CD34+CD38- Bone Marrow and Cord Blood-Derived SCID-Repopulating Cells with Third-Generation Lentiviral Vectors

1 reference

7 January 2021

Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin

1 reference

7 January 2021

Adenovirus vectors for gene delivery

1 reference

7 January 2021

Adenovirus-mediated in vivo gene transfer

1 reference

7 January 2021

Adenoviral vectors for gene transfer

1 reference

7 January 2021

Human Adenovirus Vectors for Gene Transfer into Mammalian Cells

1 reference

7 January 2021

Ovine adenovirus vectors mediate efficient gene transfer to skeletal muscle

1 reference

7 January 2021

Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons

1 reference

7 January 2021

Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration

1 reference

7 January 2021

Strategies to adapt adenoviral vectors for targeted delivery

1 reference

7 January 2021

1 reference

7 January 2021

Region E3 of adenovirus: A cassette of genes involved in host immunosurveillance and virus-cell interactions

1 reference

7 January 2021

Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression

1 reference

7 January 2021

Implication of interfering antibody formation and apoptosis as two different mechanisms leading to variable duration of adenovirus-mediated transgene expression in immune-competent mice

1 reference

7 January 2021

Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration

1 reference

7 January 2021

Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

1 reference

7 January 2021

E4ORF3 requirement for achieving long-term transgene expression from the cytomegalovirus promoter in adenovirus vectors

1 reference

7 January 2021

Generation of an adenovirus vector lacking E1, e2a, E3, and all of E4 except open reading frame 3.

1 reference

7 January 2021

Modulation of the inflammatory properties and hepatotoxicity of recombinant adenovirus vectors by the viral E4 gene products.

1 reference

7 January 2021

Toxicological comparison of E2a-deleted and first-generation adenoviral vectors expressing alpha1-antitrypsin after systemic delivery

1 reference

7 January 2021

Expanded-capacity adenoviral vectors--the helper-dependent vectors

1 reference

7 January 2021

High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha1-antitrypsin with negligible toxicity

1 reference

7 January 2021

Method for multiple portal vein infusions in mice: quantitation of adenovirus-mediated hepatic gene transfer.

1 reference

7 January 2021

The use of adenoviral vectors for gene therapy and gene transfer in vivo

1 reference

7 January 2021

Gene therapy for cystic fibrosis

1 reference

7 January 2021

Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease

1 reference

7 January 2021

Adeno-associated virus vectors for gene therapy: more pros than cons?

1 reference

7 January 2021

Adeno-associated virus vectors can be efficiently produced without helper virus

1 reference

7 January 2021

Production and purification of recombinant adeno-associated virus

1 reference

7 January 2021

Highly purified recombinant adeno-associated virus vectors are biologically active and free of detectable helper and wild-type viruses

1 reference

7 January 2021

The kinetics of rAAV integration in the liver

1 reference

7 January 2021

Recruitment of single-stranded recombinant adeno-associated virus vector genomes and intermolecular recombination are responsible for stable transduction of liver in vivo

1 reference

7 January 2021

Structural analysis of adeno-associated virus transduction circular intermediates.

1 reference

7 January 2021

Concatamerization of adeno-associated virus circular genomes occurs through intermolecular recombination.

1 reference

7 January 2021

Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis

1 reference

7 January 2021

Trans-splicing vectors expand the utility of adeno-associated virus for gene therapy

1 reference

7 January 2021

Overcoming adeno-associated virus vector size limitation through viral DNA heterodimerization

1 reference

7 January 2021

Increasing the size of rAAV-mediated expression cassettes in vivo by intermolecular joining of two complementary vectors

1 reference

7 January 2021

AAV vectors: is clinical success on the horizon?

1 reference

7 January 2021

Nonrandom transduction of recombinant adeno-associated virus vectors in mouse hepatocytes in vivo: cell cycling does not influence hepatocyte transduction

1 reference

7 January 2021

Phase I clinical trial utilizing gene therapy for limb girdle muscular dystrophy: alpha-, beta-, gamma-, or delta-sarcoglycan gene delivered with intramuscular instillations of adeno-associated vectors

1 reference

7 January 2021

Safety and biological efficacy of an adeno-associated virus vector-cystic fibrosis transmembrane regulator (AAV-CFTR) in the cystic fibrosis maxillary sinus.

1 reference

7 January 2021

Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector.

1 reference

7 January 2021

Development of herpes simplex virus replication-defective multigene vectors for combination gene therapy applications

1 reference

7 January 2021

The herpes simplex virus amplicon: A new eucaryotic defective-virus cloning-amplifying vector

1 reference

7 January 2021

Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli: rescue of replication-competent virus progeny and packaging of amplicon vectors

1 reference

7 January 2021

Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy

1 reference

7 January 2021

Herpes simplex virus vector-mediated expression of Bcl-2 prevents 6-hydroxydopamine-induced degeneration of neurons in the substantia nigra in vivo

1 reference

7 January 2021

Cytokine gene therapy of autoimmune demyelination revisited using herpes simplex virus type-1-derived vectors

1 reference

7 January 2021

Significantly increased expression of beta-glucuronidase in the central nervous system of mucopolysaccharidosis type VII mice from the latency-associated transcript promoter in a nonpathogenic herpes simplex virus type 1 vector

1 reference

7 January 2021

Integrating adenovirus-adeno-associated virus hybrid vectors devoid of all viral genes.

1 reference

7 January 2021

Site-specific integration mediated by a hybrid adenovirus/adeno-associated virus vector.

1 reference

7 January 2021

Adeno-associated virus site-specifically integrates into a muscle-specific DNA region

1 reference

7 January 2021

Site-specific integration by adeno-associated virus

1 reference

7 January 2021

Genomic integration and gene expression by a modified adenoviral vector

1 reference

7 January 2021

A phage integrase directs efficient site-specific integration in human cells

1 reference

7 January 2021

Mammalian genomes contain active recombinase recognition sites

1 reference

7 January 2021

Gene therapy using SV40-derived vectors: what does the future hold?

1 reference

7 January 2021

RNA viruses: emerging vectors for vaccination and gene therapy

1 reference

7 January 2021

Evaluation of recombinant alphaviruses as vectors in gene therapy

1 reference

7 January 2021

Development of replicative and nonreplicative hepatitis B virus vectors

1 reference

7 January 2021

Negative-strand RNA viruses: genetic engineering and applications

1 reference

7 January 2021

Epstein-Barr virus vectors for gene expression and transfer

1 reference

7 January 2021